Ohio State vs Penn State Prediction, Odds, Picks, Best Bets for Week 10 2025

The Ohio State Buckeyes will face the Penn State Nittany Lions in college football action on Saturday.

We've got you covered, in terms of the most important information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Ohio State vs Penn State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-1351) | Penn State: (+810)
• Spread: Ohio State: -18.5 (-110) | Penn State: +18.5 (-110)
• Total: 44.5 -- Over: (-105) | Under: (-115)

Ohio State vs Penn State Betting Trends

• Ohio State has six wins in seven games against the spread this season.
• Ohio State's ATS record as 18.5-point or bigger favorites is 3-1.
• Ohio State has had two games (out of seven) go over the total this year.
• Penn State has one win against the spread this year.
• This year, five of Penn State's seven games have gone over the point total.

Ohio State vs Penn State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (85.7%)

Ohio State vs Penn State Point Spread

Penn State is listed as an underdog by 18.5 points (-110 odds), and Ohio State, the favorite, is -110 to cover.

Ohio State vs Penn State Over/Under

The over/under for the Ohio State versus Penn State game on Nov. 1 has been set at 44.5, with -105 odds on the over and -115 odds on the under.

Ohio State vs Penn State Moneyline

Looking at the moneyline for Ohio State-Penn State, Ohio State is the favorite at -1351, and Penn State is +810.

Ohio State vs. Penn State Points Insights

Ohio State vs. Penn State Game Info

• Game day: Saturday, November 1, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Columbus, Ohio
• Stadium: Ohio Stadium

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Check out even more in-depth Ohio State vs. Penn State analysis on FanDuel Research.