Ohio State vs Penn State Prediction, Odds, Picks, Best Bets for Week 10 2025

College football's Saturday schedule includes the Ohio State Buckeyes taking on the Penn State Nittany Lions.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ohio State vs Penn State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-1786) | Penn State: (+980)
• Spread: Ohio State: -20.5 (-110) | Penn State: +20.5 (-110)
• Total: 43.5 -- Over: (-110) | Under: (-110)

Ohio State vs Penn State Betting Trends

• Ohio State is 6-1-0 against the spread this season.
• For the season, Ohio State is 3-1 as 20.5-point or better favorites.
• Ohio State has had two games (out of seven) hit the over this season.
• Penn State has but one win versus the spread this season.
• Of seven Penn State games so far this year, five have gone over the total.

Ohio State vs Penn State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (85.8%)

Ohio State vs Penn State Point Spread

Penn State is an underdog by 20.5 points against Ohio State. Penn State is -110 to cover the spread, and Ohio State is -110.

Ohio State vs Penn State Over/Under

The Ohio State-Penn State game on Nov. 1 has been given an over/under of 43.5 points. The over is -110 and the under is -110.

Ohio State vs Penn State Moneyline

Penn State is the underdog, +980 on the moneyline, while Ohio State is a -1786 favorite.

Ohio State vs. Penn State Points Insights

Ohio State vs. Penn State Game Info

• Game day: Saturday, November 1, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Columbus, Ohio
• Stadium: Ohio Stadium

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Check out even more in-depth Ohio State vs. Penn State analysis on FanDuel Research.