Missouri vs Kansas Prediction, Odds, Picks, Best Bets for Week 2 2025

The Saturday schedule in college football includes a matchup between the Missouri Tigers and the Kansas Jayhawks.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Missouri vs Kansas Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Missouri: (-235) | Kansas: (+190)
• Spread: Missouri: -6.5 (-114) | Kansas: +6.5 (-106)
• Total: 50.5 -- Over: (-114) | Under: (-106)

Missouri vs Kansas Betting Trends

• Missouri hasn won once against the spread this season.
• Missouri is unbeaten ATS (1-0) as a 6.5-point favorite or greater this season.
• One of one Missouri games have hit the over this year.
• Kansas has but one win versus the spread this year.
• Kansas and its opponent have yet to hit the over this season.

Missouri vs Kansas Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (64.4%)

Missouri vs Kansas Point Spread

Kansas is the underdog by 6.5 points against Missouri. Kansas is -114 to cover the spread, and Missouri is -106.

Missouri vs Kansas Over/Under

A combined point total of 50.5 has been set for Missouri-Kansas on Sept. 6, with the over at -114 and the under at -106.

Missouri vs Kansas Moneyline

Missouri is the favorite, -235 on the moneyline, while Kansas is a +190 underdog.

Missouri vs. Kansas Points Insights

• The average implied total for the Tigers last season was 32.8 points, 3.8 more points than their implied total of 29 points in Saturday's game.
• The average implied point total last season for the Jayhawks (30.0) is 8.0 more points than the team's implied total in this matchup (22).

Missouri vs. Kansas Game Info

• Game day: Saturday, September 6, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN2
• Location: Columbia, Missouri
• Stadium: Memorial Stadium/Faurot Field

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Check out even more in-depth Missouri vs. Kansas analysis on FanDuel Research.