Missouri vs Kansas Prediction, Odds, Picks, Best Bets for Week 2 2025

The Missouri Tigers will face the Kansas Jayhawks in college football action on Saturday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Missouri vs Kansas Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Missouri: (-210) | Kansas: (+172)
• Spread: Missouri: -5.5 (-110) | Kansas: +5.5 (-110)
• Total: 49.5 -- Over: (-114) | Under: (-106)

Missouri vs Kansas Betting Trends

• Missouri hasn't lost a game against the spread this season.
• Missouri has yet to lose ATS (1-0) as a 5.5-point favorite or greater this season.
• All one of Missouri's games have gone over the point total this season.
• Kansas has one win against the spread this year.
• No Kansas game has gone over the point total this year.

Missouri vs Kansas Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (62.8%)

Missouri vs Kansas Point Spread

Missouri is favored by 5.5 points over Kansas. Missouri is -110 to cover the spread, with Kansas being -110.

Missouri vs Kansas Over/Under

An over/under of 49.5 has been set for Missouri-Kansas on Sept. 6, with the over being -114 and the under -106.

Missouri vs Kansas Moneyline

Kansas is the underdog, +172 on the moneyline, while Missouri is a -210 favorite.

Missouri vs. Kansas Points Insights

• The Tigers had an average implied point total of 32.8 last season, which is 4.8 points higher than their implied total in Saturday's game (28).
• The Jayhawks' average implied point total last season (30.0 points) is 8.0 points higher than their implied total in this matchup (22 points).

Missouri vs. Kansas Game Info

• Game day: Saturday, September 6, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN2
• Location: Columbia, Missouri
• Stadium: Memorial Stadium/Faurot Field

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Missouri vs. Kansas analysis on FanDuel Research.