Louisville vs Cal Prediction, Odds, Picks, Best Bets for Week 11 2025

The Louisville Cardinals will face the California Golden Bears in college football action on Saturday.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Louisville vs Cal Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-1099) | Cal: (+700)
• Spread: Louisville: -18.5 (-105) | Cal: +18.5 (-115)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Louisville vs Cal Betting Trends

• Louisville has three wins in eight games against the spread this year.
• Louisville is winless ATS (0-3) as an 18.5-point favorite or greater this season.
• There have been four Louisville games (of eight) that went over the total this season.
• Cal has covered the spread three times in nine games.
• Cal has played two games (out of nine) which finished over the total this season.

Louisville vs Cal Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (92.7%)

Louisville vs Cal Point Spread

Louisville is favored by 18.5 points versus Cal. Louisville is -105 to cover the spread, while Cal is -115.

Louisville vs Cal Over/Under

A combined point total of 49.5 has been set for Louisville-Cal on Nov. 8, with the over at -110 and the under at -110.

Louisville vs Cal Moneyline

Cal is the underdog, +700 on the moneyline, while Louisville is a -1099 favorite.

Louisville vs. Cal Points Insights

Louisville vs. Cal Game Info

• Game day: Saturday, November 8, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. Cal analysis on FanDuel Research.