Iowa vs Clemson College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament First Round

The No. 8 Clemson Tigers (24-10) will be trying to move on to the second round of the NCAA Tournament when they meet the No. 9 Iowa Hawkeyes (21-12) on Friday. This 8-9 matchup in the South Region bracket tips off at 6:50 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa vs. Clemson Game Info and Odds

• Game day: Friday, March 20, 2026
• Game time: 6:50 p.m. ET
• TV channel: TNT
• Location: Tampa, Florida
• Arena: Benchmark International Arena

Iowa vs. Clemson Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Clemson win (50.5%)

See these betting trends and insights before you wager on Friday's Iowa-Clemson spread (Iowa -1.5) or over/under (130.5 points).

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Iowa vs. Clemson: ATS Betting Stats and Trends

• Iowa has won 18 games against the spread this season, while failing to cover 15 times.
• Clemson has won 17 games against the spread this season, while failing to cover 17 times.
• Iowa covers the spread when it is a 1.5-point favorite or more 60.9% of the time. That's less often than Clemson covers as an underdog of 1.5 or more (66.7%).
• When playing at home, the Hawkeyes own a better record against the spread (10-7-0) compared to their ATS record in away games (5-6-0).
• Against the spread, the Tigers have had better results away (7-4-0) than at home (7-9-0).

Iowa vs. Clemson: Moneyline Betting Stats

• Iowa has been chosen as the moneyline favorite in 20 games this year and has walked away with the win 17 times (85%) in those games.
• The Hawkeyes have a mark of 16-3 in contests where bookmakers favor them by -128 or better on the moneyline.
• Clemson has won 16.7% of the games this season it was the moneyline underdog (1-5).
• The Tigers are 1-5 (winning just 16.7% of their games) when playing as a moneyline underdog of +106 or longer.
• Iowa has an implied victory probability of 56.1% according to the moneyline set for this matchup.

Iowa vs. Clemson Head-to-Head Comparison

• Iowa averages 75.2 points per game (192nd in college basketball) while giving up 66 per outing (18th in college basketball). It has a +305 scoring differential overall and outscores opponents by 9.2 points per game.
• Bennett Stirtz paces Iowa, averaging 20 points per game (33rd in college basketball).
• Clemson is outscoring opponents by 7.4 points per game, with a +252 scoring differential overall. It puts up 74.1 points per game (229th in college basketball) and gives up 66.7 per contest (26th in college basketball).
• Clemson's leading scorer, RJ Godfrey, is 721st in the country, scoring 11.9 points per game.
• The Hawkeyes are 358th in the nation at 26.8 rebounds per game. That's similar to the 26.2 their opponents average.
• Tavion Banks averages 4.7 rebounds per game (ranking 729th in college basketball) to lead the Hawkeyes.
• The Tigers come out on top in the rebound battle by an average of 1.9 boards. They are collecting 31.5 rebounds per game (211th in college basketball) compared to their opponents' 29.6.
• Carter Welling's 5.4 rebounds per game lead the Tigers and rank 451st in the nation.
• Iowa averages 107.5 points per 100 possessions on offense (16th in college basketball), and allows 94.3 points per 100 possessions (152nd in college basketball).
• The Tigers' 101.9 points per 100 possessions on offense rank 80th in college basketball, and the 91.7 points they concede per 100 possessions rank 85th in college basketball.

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