Iowa State vs Grambling College Basketball Prediction, Odds, Picks, Best Bets for Nov. 6

The Iowa State Cyclones (1-0) face the Grambling Tigers (1-0) on November 6, 2025.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Grambling Game Info and Odds

• Game day: Thursday, November 6, 2025
• Game time: 8 p.m. ET
• TV channel: ESPN+
• Location: Ames, Iowa
• Arena: James H. Hilton Coliseum

Iowa State vs. Grambling Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (98.3%)

Before making an informed wager on Iowa State-Grambling matchup (in which Iowa State is a 33.5-point favorite and the over/under has been set at 144.5 points), keep reading for a few betting trends and insights for Thursday's game.

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Iowa State vs. Grambling: ATS Betting Stats and Trends

• Iowa State went 20-15-0 ATS last season.
• Grambling won 14 games against the spread last year, while failing to cover 17 times.
• When playing at home last season, the Cyclones sported a worse record against the spread (9-8-0) compared to their ATS record in road games (7-4-0).
• The Tigers' winning percentage against the spread at home was .200 (2-8-0) last season. On the road, it was .500 (8-8-0).

Iowa State vs. Grambling Head-to-Head Comparison

• Last year, Iowa State was 34th in college basketball offensively (80.3 points scored per game) and 61st defensively (68.3 points conceded).
• Last season, Iowa State was 142nd in college basketball in rebounds (32.7 per game) and 31st in rebounds conceded (28.3).
• Iowa State was 77th in the country in assists (15.0 per game) last season.
• In terms of turnovers, Iowa State was 232nd in college basketball in committing them (11.6 per game) last year. It was 13th-best in forcing them (14.4 per game).
• Grambling found it difficult to put up points last year, ranking 25th-worst in college basketball with 66.8 points per game. It fared better on defense, ranking 52nd by giving up 67.7 points per contest.
• Grambling was 234th in the nation with 31.0 boards per game. Meanwhile, it ranked 265th with 32.4 rebounds allowed per game.
• Last year Grambling ranked 323rd in college basketball in assists, delivering 11.4 per game.
• Grambling committed 12.2 turnovers per game (277th-ranked in college basketball) this season, while forcing 11.6 turnovers per contest (146th-ranked).

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