Houston vs West Virginia Prediction, Odds, Picks, Best Bets for Week 10 2025

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College football's Saturday slate includes the Houston Cougars taking on the West Virginia Mountaineers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Houston vs West Virginia Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Houston: (-481) | West Virginia: (+370)
Spread: Houston: -13.5 (-105) | West Virginia: +13.5 (-115)
Total: 49.5 -- Over: (-110) | Under: (-110)

Houston is 6-2-0 against the spread this year.
Houston is unbeaten ATS (3-0) as a 13.5-point favorite or greater this year.
Out of eight Houston games so far this year, five have gone over the total.
West Virginia has four wins in eight contests against the spread this year.
West Virginia has won twice ATS (2-1) as a 13.5-point underdog or more this year.
There have been three West Virginia games (out of eight) that went over the total this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cougars win (80.2%)

Houston is favored by 13.5 points versus West Virginia. Houston is -105 to cover the spread, while West Virginia is -115.

The over/under for the Houston versus West Virginia matchup on Nov. 1 has been set at 49.5, with -110 odds on the over and -110 odds on the under.

The Houston vs West Virginia moneyline has Houston as a -481 favorite, while West Virginia is a +370 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Houston	28.8	63	18.6	28	47.3	8
West Virginia	20.5	114	29.9	108	52.4	8

Check out even more in-depth Houston vs. West Virginia analysis on FanDuel Research.

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