Houston vs West Virginia Prediction, Odds, Picks, Best Bets for Week 10 2025

On Saturday in college football, the Houston Cougars are playing the West Virginia Mountaineers.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Houston vs West Virginia Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Houston: (-549) | West Virginia: (+410)
• Spread: Houston: -13.5 (-108) | West Virginia: +13.5 (-112)
• Total: 48.5 -- Over: (-105) | Under: (-115)

Houston vs West Virginia Betting Trends

• Houston has covered the spread six times in eight games.
• Houston has yet to lose ATS (3-0) as a 13.5-point favorite or greater this season.
• There have been five Houston games (of eight) that hit the over this year.
• Against the spread, West Virginia is 4-4-0 this year.
• West Virginia has won twice ATS (2-1) as a 13.5-point underdog or greater this year.
• There have been three West Virginia games (out of eight) that went over the total this year.

Houston vs West Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cougars win (79.9%)

Houston vs West Virginia Point Spread

Houston is favored by 13.5 points against West Virginia. Houston is -108 to cover the spread, while West Virginia is -112.

Houston vs West Virginia Over/Under

Houston versus West Virginia, on Nov. 1, has an over/under of 48.5, with the over being -105 and the under -115.

Houston vs West Virginia Moneyline

Houston is a -549 favorite on the moneyline, while West Virginia is a +410 underdog.

Houston vs. West Virginia Points Insights

Houston vs. West Virginia Game Info

• Game day: Saturday, November 1, 2025
• Game time: 12 p.m. ET
• TV channel: Fox Sports 1
• Location: Houston, Texas
• Stadium: TDECU Stadium

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Check out even more in-depth Houston vs. West Virginia analysis on FanDuel Research.