Houston vs Rice Prediction, Odds, Picks, Best Bets for Week 2 2025

NCAA football action on Saturday includes the Houston Cougars facing the Rice Owls.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Houston vs Rice Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Houston: (-649) | Rice: (+460)
• Spread: Houston: -13.5 (-114) | Rice: +13.5 (-106)
• Total: 38.5 -- Over: (-115) | Under: (-105)

Houston vs Rice Betting Trends

• Houston hasn won once against the spread this year.
• Houston is unbeaten ATS (1-0) as a 13.5-point favorite or greater this year.
• Rice has but one win versus the spread this year.
• Not one of Rice's one games has gone over the point total in 2025.

Houston vs Rice Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cougars win (80.5%)

Houston vs Rice Point Spread

Rice is listed as an underdog by 13.5 points (-106 odds), and Houston, the favorite, is -114 to cover.

Houston vs Rice Over/Under

The over/under for Houston-Rice on Sept. 6 is 38.5. The over is -115, and the under is -105.

Houston vs Rice Moneyline

Looking at the moneyline for Houston-Rice, Houston is the favorite at -649, and Rice is +460.

Houston vs. Rice Points Insights

• The average implied total for the Cougars last season was 28.2 points, 2.2 more points than their implied total of 26 points in Saturday's game.
• The average implied point total last season for the Owls (30.0) is 17.0 more points than the team's implied total in this matchup (13).

Houston vs. Rice Game Info

• Game day: Saturday, September 6, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN+
• Location: Houston, Texas
• Stadium: Rice Stadium

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Check out even more in-depth Houston vs. Rice analysis on FanDuel Research.