Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 6:12 p.m.

The Cleveland Guardians versus the Minnesota Twins is on the MLB schedule for Wednesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Guardians vs Twins Game Info

• Cleveland Guardians (54-48) vs. Minnesota Twins (49-53)
• Date: Wednesday, July 22, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Twins.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-144) | MIN: (+122)
• Spread: CLE: -1.5 (+146) | MIN: +1.5 (-178)
• Total: 8 -- Over: (-112) | Under: (-108)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 4-6, 4.55 ERA vs Bailey Ober (Twins) - 7-3, 4.32 ERA

This contest's pitching matchup is set, as the Guardians will send Slade Cecconi (4-6) to the mound, while Bailey Ober (7-3) will get the nod for the Twins. When Cecconi starts, his team is 9-8-0 against the spread this season. Cecconi's team has a record of 3-1 this season when he starts and they are the favorite on the moneyline. The Twins have a 9-5-0 record against the spread in Ober's starts. The Twins have a 6-4 record in Ober's 10 starts this season when they were the moneyline underdog.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.4%)

Guardians vs Twins Moneyline

• Minnesota is a +122 underdog on the moneyline, while Cleveland is a -144 favorite at home.

Guardians vs Twins Spread

• The Guardians are hosting the Twins and are favored by 1.5 runs on the spread. The Guardians are +146 to cover the runline, with the Twins being -178.

Guardians vs Twins Over/Under

• A combined run total of 8 has been set for Guardians-Twins on July 22, with the over at -112 and the under at -108.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have come away with 27 wins in the 51 contests they have been listed as the favorites in this season.
• This season Cleveland has come away with a win nine times in 13 chances when named as a favorite of at least -144 on the moneyline.
• The Guardians and their opponents have hit the over in 46 of their 96 games with a total set by oddsmakers this season.
• The Guardians are 48-48-0 against the spread in their 96 games that had a posted line this season.
• The Twins have been the moneyline underdog 63 total times this season. They've gone 28-35 in those games.
• Minnesota has a 13-16 record (winning 44.8% of its games) when playing as a moneyline underdog of +122 or longer.
• The Twins have played in 100 games with a set over/under, and have combined with opponents to go over the total 58 times (58-40-2).
• The Twins have put together a 54-46-0 record against the spread this season (covering 54% of the time).

Guardians Player Leaders

• Chase DeLauter has 92 hits and an OBP of .353, both of which lead Cleveland hitters this season. He has a .288 batting average and a slugging percentage of .458.
• Among qualified batters in MLB, his batting average ranks 19th, his on-base percentage ranks 43rd, and he is 51st in slugging.
• DeLauter hopes to build on a six-game hitting streak in this matchup. In his last 10 games he is hitting .375 with three doubles, three home runs, four walks and nine RBIs.
• Brayan Rocchio has hit nine homers this season while driving in 47 runs. He's batting .274 this season and slugging .406 with an on-base percentage of .337.
• His batting average ranks 44th among qualified players, his on-base percentage 66th, and his slugging percentage 97th.
• Rocchio has picked up a hit in four games in a row. During his last five outings he is hitting .238 with a home run and three RBIs.
• Steven Kwan has 75 hits this season and has a slash line of .239/.347/.299.
• Travis Bazzana has nine home runs, 33 RBI and a batting average of .248 this season.
• Bazzana heads into this game on a two-game hitting streak. In his last five games he is hitting .389 with a triple, two home runs, three walks and five RBIs.

Twins Player Leaders

• Byron Buxton is leading the Twins with 86 hits. He's batting .275 and slugging .572 with an on-base percentage of .330.
• He is 42nd in batting average, 77th in on-base percentage and third in slugging percentage among all qualifying batters in the majors.
• Buxton hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .333 with a double, a walk and two RBIs.
• Brooks Lee is batting .252 with 15 doubles, three triples, 14 home runs and 28 walks. He's slugging .429 with an on-base percentage of .309.
• He is 80th in batting average, 112th in on-base percentage and 74th in slugging percentage in the majors.
• Josh Bell has a team-high .428 slugging percentage.
• Kody Clemens has 18 doubles, three triples, 18 home runs and 22 walks while hitting .241.

Guardians vs Twins Head to Head

• 7/21/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/20/2025: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/20/2025: 6-0 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!