Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 1:12 a.m.

The MLB slate on Wednesday includes the Cleveland Guardians taking on the Minnesota Twins.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Twins Game Info

• Cleveland Guardians (54-48) vs. Minnesota Twins (49-53)
• Date: Wednesday, July 22, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Twins.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-122) | MIN: (+104)
• Spread: CLE: +1.5 (-220) | MIN: -1.5 (+180)
• Total: 8 -- Over: (-110) | Under: (-110)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 4-6, 4.55 ERA vs Bailey Ober (Twins) - 7-3, 4.32 ERA

The Guardians will call on Slade Cecconi (4-6) versus the Twins and Bailey Ober (7-3). Cecconi's team is 9-8-0 against the spread in his starts this season. When Cecconi starts a game and his team is the favorite on the moneyline, they have a record of 3-1. The Twins have a 9-5-0 ATS record in Ober's 14 starts with a set spread. The Twins have been the moneyline underdog in 10 of Ober's starts this season, and they went 6-4 in those games.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.7%)

Guardians vs Twins Moneyline

• Looking at the moneyline for Guardians-Twins, Cleveland is the favorite at -122, and Minnesota is +104 playing on the road.

Guardians vs Twins Spread

• The Twins are 1.5-run favorites against the spread for this matchup with the Guardians. The Twins are +180 to cover, while the Guardians are -220 to cover as a 1.5-run underdog on the runline.

Guardians vs Twins Over/Under

• An over/under of 8 has been set for Guardians-Twins on July 22, with the over being -110 and the under -110.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have won in 27, or 52.9%, of the 51 contests they have been named as odds-on favorites in this year.
• This season Cleveland has come away with a win 19 times in 36 chances when named as a favorite of at least -122 on the moneyline.
• The Guardians and their opponents have gone over in 46 of their 96 games with a total set by sportsbooks this season.
• The Guardians are 48-48-0 against the spread in their 96 games that had a posted line this season.
• The Twins have been the moneyline underdog 63 total times this season. They've gone 28-35 in those games.
• Minnesota has a 25-30 record (winning 45.5% of its games) when playing as a moneyline underdog of +104 or longer.
• The Twins have combined with opponents to go over the total 58 times this season for a 58-40-2 record against the over/under.
• The Twins have covered 54% of their games this season, going 54-46-0 against the spread.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in OBP (.353) and total hits (92) this season. He's batting .288 batting average while slugging .458.
• Among the qualified batters in MLB, his batting average ranks 19th, his on-base percentage ranks 42nd, and he is 53rd in slugging.
• DeLauter has recorded a base hit in six straight games. In his last 10 games he is hitting .375 with three doubles, three home runs, four walks and nine RBIs.
• Brayan Rocchio has an OPS of .743, fueled by an OBP of .337 and a team-best slugging percentage of .406 this season. He's batting .274.
• Among qualifying hitters, his batting average places him 44th, his on-base percentage 67th, and his slugging percentage 96th.
• Rocchio enters this matchup looking to extend his four-game hit streak. In his last five games he is batting .238 with a home run and three RBIs.
• Steven Kwan is batting .239 with a .299 slugging percentage and 18 RBI this year.
• Travis Bazzana has nine home runs, 33 RBI and a batting average of .248 this season.
• Bazzana enters this game on a two-game hitting streak. During his last five outings he is hitting .389 with a triple, two home runs, three walks and five RBIs.

Twins Player Leaders

• Byron Buxton has racked up 86 hits, a team-high for the Twins. He's batting .275 and slugging .572 with an on-base percentage of .330.
• Including all qualified hitters in MLB, he ranks 42nd in batting average, 78th in on-base percentage and third in slugging percentage.
• Buxton heads into this game on a four-game hitting streak. In his last five games he is batting .333 with a double, a walk and two RBIs.
• Brooks Lee is batting .252 with 15 doubles, three triples, 14 home runs and 28 walks. He's slugging .429 with an on-base percentage of .309.
• He ranks 80th in batting average, 112th in on-base percentage and 74th in slugging percentage in MLB.
• Josh Bell has a slugging percentage of .428, a team-high for the Twins.
• Kody Clemens has 18 doubles, three triples, 18 home runs and 22 walks while batting .241.

Guardians vs Twins Head to Head

• 7/21/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/20/2025: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/20/2025: 6-0 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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