Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 6:12 p.m.

The Cleveland Guardians versus the Minnesota Twins is on the MLB schedule for Tuesday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Twins Game Info

• Cleveland Guardians (53-48) vs. Minnesota Twins (49-52)
• Date: Tuesday, July 21, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Twins.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-154) | MIN: (+130)
• Spread: CLE: -1.5 (+132) | MIN: +1.5 (-160)
• Total: 8 -- Over: (-118) | Under: (-104)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 8-5, 2.73 ERA vs Kendry Rojas (Twins) - 1-1, 2.79 ERA

The probable starters are Parker Messick (8-5) for the Guardians and Kendry Rojas (1-1) for the Twins. Messick's team is 9-10-0 against the spread in his starts this season. Messick's team has a record of 6-8 this season when he starts and they are the favorite on the moneyline. Rojas has started two games with set spreads, and the Twins went 1-1-0. The Twins were the moneyline underdog for one Rojas start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.2%)

Guardians vs Twins Moneyline

• The moneyline numbers for Guardians vs. Twins reveal Cleveland as the favorite (-154) and Minnesota as the underdog (+130) on the road.

Guardians vs Twins Spread

• The Guardians are favored by 1.5 runs at home against the Twins. The Guardians are +132 to cover the spread, while the Twins are -160.

Guardians vs Twins Over/Under

• The over/under for Guardians-Twins on July 21 is 8. The over is -118, and the under is -104.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been favorites in 50 games this season and have come away with the win 26 times (52%) in those contests.
• This season Cleveland has been victorious seven times in 11 chances when named as a favorite of at least -154 on the moneyline.
• The Guardians and their opponents have hit the over in 46 of their 95 games with a total set by oddsmakers this season.
• The Guardians are 47-48-0 against the spread in their 95 games that had a posted line this season.
• The Twins are 28-34 in games they were the underdog on the moneyline (winning 45.2% of those games).
• Minnesota is 7-9 (winning 43.8% of its games) when playing as a moneyline underdog of +130 or longer.
• In the 99 games bookmakers have set an over/under for the Twins, they have combined with opponents to go over the total 58 times (58-39-2).
• The Twins have a 54-45-0 record against the spread this season (covering 54.5% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 90 hits and an OBP of .351 this season. He has a .286 batting average and a slugging percentage of .457.
• Among all qualified batters in baseball, he ranks 22nd in batting average, 47th in on-base percentage, and 53rd in slugging.
• DeLauter will look for his sixth straight game with a hit in this contest. In his last five games he is hitting .381 with three doubles, a home run, a walk and five RBIs.
• Brayan Rocchio leads Cleveland in slugging percentage (.405) thanks to 25 extra-base hits. He's batting .271 with an on-base percentage of .335.
• Among all qualified, he is 48th in batting average, 70th in on-base percentage and 99th in slugging percentage.
• Rocchio has picked up a hit in three straight games. During his last five outings he is batting .227 with two home runs and four RBIs.
• Steven Kwan is batting .238 with a .296 slugging percentage and 17 RBI this year.
• Travis Bazzana has been key for Cleveland with 64 hits, an OBP of .337 plus a slugging percentage of .419.

Twins Player Leaders

• Byron Buxton paces the Twins with 85 hits. He's batting .275 and slugging .576 with an on-base percentage of .331.
• Including all qualified hitters in the big leagues, he ranks 42nd in batting average, 76th in on-base percentage and third in slugging percentage.
• Buxton hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .267 with a double, a walk and two RBIs.
• Brooks Lee is slugging .429 to lead his team. He has a batting average of .252 with an on-base percentage of .309.
• He is currently 80th in batting average, 114th in on-base percentage and 70th in slugging percentage among all qualifying hitters.
• Josh Bell has a team-best .427 slugging percentage.
• Kody Clemens is batting .237 with 18 doubles, three triples, 18 home runs and 22 walks.

Guardians vs Twins Head to Head

• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/20/2025: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/20/2025: 6-0 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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