Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 7:12 a.m.

The MLB's Tuesday slate includes the Cleveland Guardians facing the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Guardians vs Twins Game Info

• Cleveland Guardians (53-48) vs. Minnesota Twins (49-52)
• Date: Tuesday, July 21, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Twins.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-148) | MIN: (+126)
• Spread: CLE: -1.5 (+130) | MIN: +1.5 (-156)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 8-5, 2.73 ERA vs Kendry Rojas (Twins) - 1-1, 2.79 ERA

The Guardians will give the nod to Parker Messick (8-5, 2.73 ERA), who is eyeing win No. 9 on the season, and the Twins will turn to Kendry Rojas (1-1, 2.79 ERA). Messick and his team have a record of 9-10-0 against the spread when he starts. Messick's team has won 42.9% of his starts when they are favored on the moneyline (6-8). Rojas has started two games with set spreads, and the Twins went 1-1-0. The Twins were named the moneyline underdog for one Rojas start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.8%)

Guardians vs Twins Moneyline

• Looking at the moneyline for Guardians-Twins, Cleveland is the favorite at -148, and Minnesota is +126 playing on the road.

Guardians vs Twins Spread

• The Twins are at the Guardians, and are +1.5 on the runline. The Twins are +130 to cover the spread, and the Guardians are -156.

Guardians vs Twins Over/Under

• The over/under for Guardians-Twins on July 21 is 8.5. The over is -102, and the under is -120.

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Guardians vs Twins Betting Trends

• The Guardians have won in 26, or 52%, of the 50 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 7-4 in contests when oddsmakers favor them by -148 or more on the moneyline.
• The Guardians and their opponents have hit the over in 46 of their 95 games with a total set by oddsmakers this season.
• In 95 games with a line this season, the Guardians have a mark of 47-48-0 against the spread.
• The Twins have won 28 of the 62 games they were the moneyline underdog this season (45.2%).
• When playing as a moneyline underdog with odds of +126 or longer, Minnesota has gone 10-12 (45.5%).
• The Twins have played in 99 games with a set over/under, and have combined with their opponents to go over the total 58 times (58-39-2).
• The Twins have collected a 54-45-0 record against the spread this season (covering 54.5% of the time).

Guardians Player Leaders

• Chase DeLauter has 90 hits and an OBP of .351, both of which lead Cleveland hitters this season. He has a .286 batting average and a slugging percentage of .457.
• Among all qualifying hitters in MLB, his batting average ranks 22nd, his on-base percentage ranks 47th, and he is 53rd in slugging.
• DeLauter will look for his sixth straight game with a hit in this contest. In his last five games he is hitting .381 with three doubles, a home run, a walk and five RBIs.
• Brayan Rocchio leads Cleveland in slugging percentage (.405) thanks to 25 extra-base hits. He's batting .271 with an on-base percentage of .335.
• His batting average ranks 48th among qualified players, his on-base percentage 70th, and his slugging percentage 99th.
• Rocchio heads into this matchup looking to extend his three-game hit streak. In his last five games he is batting .227 with two home runs and four RBIs.
• Steven Kwan is batting .238 with a .296 slugging percentage and 17 RBI this year.
• Travis Bazzana is batting .246 with a .337 OBP and 32 RBI for Cleveland this season.

Twins Player Leaders

• Byron Buxton has put up 85 hits, a team-best for the Twins. He's batting .275 and slugging .576 with an on-base percentage of .331.
• Including all qualified hitters in MLB, his batting average puts him 42nd, his on-base percentage is 76th, and he is third in slugging.
• Buxton hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .267 with a double, a walk and two RBIs.
• Brooks Lee's .429 slugging percentage paces his team. He has a batting average of .252 with an on-base percentage of .309.
• He is 80th in batting average, 114th in on-base percentage and 70th in slugging percentage in MLB.
• Josh Bell has put up a slugging percentage of .427, a team-high for the Twins.
• Kody Clemens is batting .237 with 18 doubles, three triples, 18 home runs and 22 walks.

Guardians vs Twins Head to Head

• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/20/2025: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/20/2025: 6-0 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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