Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 8

Odds updated as of 9:13 a.m.

The Cleveland Guardians are among the MLB squads in action on Friday, versus the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Guardians vs Twins Game Info

• Cleveland Guardians (20-19) vs. Minnesota Twins (16-22)
• Date: Friday, May 8, 2026
• Time: 7:15 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Apple TV+

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-138) | MIN: (+118)
• Spread: CLE: -1.5 (+155) | MIN: +1.5 (-188)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 3-1, 2.40 ERA vs Connor Prielipp (Twins) - 1-0, 3.86 ERA

The Guardians will call on Parker Messick (3-1) against the Twins and Connor Prielipp (1-0). Messick's team is 5-2-0 against the spread this season in his starts. When Messick starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Twins have gone 2-1-0 ATS in Prielipp's three starts that had a set spread. The Twins are 1-2 in Prielipp's three starts this season that they were the underdog on the moneyline.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.6%)

Guardians vs Twins Moneyline

• Looking at the moneyline for Guardians-Twins, Cleveland is the favorite at -138, and Minnesota is +118 playing on the road.

Guardians vs Twins Spread

• The Twins are +1.5 on the run line against the Guardians. The Twins are -188 to cover, and the Guardians are +155.

Guardians vs Twins Over/Under

• Guardians versus Twins, on May 8, has an over/under of 7.5, with the over being -110 and the under -110.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been favorites in 17 games this season and have come away with the win eight times (47.1%) in those contests.
• This season Cleveland has come away with a win one time in three chances when named as a favorite of at least -138 on the moneyline.
• The Guardians and their opponents have gone over in 19 of their 38 games with a total set by sportsbooks this season.
• In 38 games with a line this season, the Guardians have a mark of 20-18-0 against the spread.
• The Twins are 12-15 in games they were the underdog on the moneyline (winning 44.4% of those games).
• When it has played as a moneyline underdog with odds of +118 or longer, Minnesota has a 7-5 record (winning 58.3% of its games).
• The Twins have had an over/under set by bookmakers 38 times, and have combined with opponents to go over the total in 24 of those games (24-13-1).
• The Twins have an 18-20-0 record ATS this season (covering 47.4% of the time).

Guardians Player Leaders

• Jose Ramirez is hitting .211 with eight doubles, six home runs and 28 walks. He has an on-base percentage of .341 while slugging .394.
• Among qualifying hitters, he ranks 146th in batting average, his on-base percentage ranks 76th, and he is 97th in slugging.
• Chase DeLauter has 38 hits and an OBP of .392 to go with a slugging percentage of .548. All three of those stats lead Cleveland hitters this season. He's batting .306.
• He ranks 22nd in batting average, 16th in on-base percentage and 17th in slugging among qualified hitters.
• DeLauter enters this matchup looking to extend his 11-game hit streak. In his last 10 outings he is hitting .514 with five doubles, a home run, five walks and seven RBIs.
• Brayan Rocchio has 32 hits this season and has a slash line of .262/.343/.369.
• Angel Martinez has been key for Cleveland with 30 hits, an OBP of .311 plus a slugging percentage of .468.

Twins Player Leaders

• Ryan Jeffers is hitting .302 with five doubles, a triple, five home runs and 17 walks. He's slugging .531 with an on-base percentage of .409.
• Byron Buxton leads his team with 36 hits and has a club-leading .514 slugging percentage. He has a batting average of .243 with an on-base percentage of .298.
• Including all qualified hitters, his batting average puts him 97th, his on-base percentage is 136th, and he is 24th in slugging.
• Brooks Lee has accumulated a team-best .326 on-base percentage.
• Luke Keaschall is hitting .234 with eight doubles, a home run and 15 walks.

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