Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 1:11 p.m.

MLB action on Sunday includes the Cleveland Guardians taking on the Minnesota Twins.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Twins Game Info

• Cleveland Guardians (21-20) vs. Minnesota Twins (17-23)
• Date: Sunday, May 10, 2026
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Twins.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-162) | MIN: (+136)
• Spread: CLE: -1.5 (+132) | MIN: +1.5 (-160)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 5-2, 3.28 ERA vs Andrew Morris (Twins) - 1-1, 4.96 ERA

This contest's pitching matchup is set, as the Guardians will send Gavin Williams (5-2) to the mound, while Andrew Morris (1-1) will take the ball for the Twins. Williams' team is 5-2-0 against the spread this season in his starts. When Williams starts a game and his team is the favorite on the moneyline, they have a record of 4-1. Morris and his team were underdogs on the moneyline every time he pitched a season ago.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.5%)

Guardians vs Twins Moneyline

• Looking at the moneyline for Guardians-Twins, Cleveland is the favorite at -162, and Minnesota is +136 playing on the road.

Guardians vs Twins Spread

• The Guardians are 1.5-run home favorites on the runline against the Twins. The Guardians are +132 to cover, and the Twins are -160.

Guardians vs Twins Over/Under

• The over/under for Guardians-Twins on May 10 is 7.5. The over is +100, and the under is -122.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been favorites in 18 games this season and have come away with the win nine times (50%) in those contests.
• Cleveland has played as a favorite of -162 or more just one time this year and came away with a loss in that game.
• The Guardians and their opponents have gone over in 20 of their 39 games with a total set by sportsbooks this season.
• The Guardians have an against the spread record of 21-18-0 in 39 games with a line this season.
• The Twins have been the moneyline underdog 28 total times this season. They've finished 12-16 in those games.
• Minnesota is 2-1 (winning 66.7% of its games) when it has played as a moneyline underdog of +136 or longer.
• The Twins have had an over/under set by oddsmakers 39 times, and have combined with opponents to go over the total in 25 of those games (25-13-1).
• The Twins have an 18-21-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez is batting .221 with eight doubles, six home runs and 30 walks. He has an on-base percentage of .352 while slugging .396.
• Among all qualifying hitters in baseball, he ranks 135th in batting average, 58th in on-base percentage, and 92nd in slugging.
• Ramirez will look for his fourth straight game with a hit in this contest. In his last five games he is batting .250 with six walks and an RBI.
• Chase DeLauter leads Cleveland with 38 hits and an OBP of .378, plus a team-best slugging percentage of .527. He's batting .295.
• His batting average is 27th among qualified players, his on-base percentage 30th, and his slugging percentage 21st.
• Brayan Rocchio has 33 hits this season and has a slash line of .256/.342/.357.
• Steven Kwan has one home run, nine RBI and a batting average of .214 this season.

Twins Player Leaders

• Byron Buxton has racked up 41 hits with a .563 slugging percentage, both team-high statistics for the Twins. He's batting .259 and with an on-base percentage of .310.
• Including all the qualifying hitters in the big leagues, he is 69th in batting average, 121st in on-base percentage and 12th in slugging percentage.
• Buxton takes a three-game hitting streak into this game. During his last five outings he is batting .292 with two doubles, three home runs and seven RBIs.
• Ryan Jeffers is batting .300 with five doubles, a triple, five home runs and 18 walks. He's slugging .520 with an on-base percentage of .408.
• Brooks Lee has put up an on-base percentage of .319, a team-high for the Twins.
• Luke Keaschall leads his team with a .319 on-base percentage.

Guardians vs Twins Head to Head

• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/20/2025: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/20/2025: 6-0 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/3/2025: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/2/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/1/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/21/2025: 5-1 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/1/2025: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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