Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for July 29

Odds updated as of 1:12 a.m.

The Wednesday schedule in MLB includes a matchup between the Cleveland Guardians and the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Reds Game Info

• Cleveland Guardians (55-54) vs. Cincinnati Reds (50-56)
• Date: Wednesday, July 29, 2026
• Time: 7:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and CleGuardians.TV

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | CIN: (+108)
• Spread: CLE: -1.5 (+130) | CIN: +1.5 (-156)
• Total: 9 -- Over: (-102) | Under: (-120)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 8-6, 4.02 ERA vs Brady Singer (Reds) - 5-9, 4.53 ERA

The Guardians will give the nod to Joey Cantillo (8-6, 4.02 ERA), who is eyeing win No. 9 on the season, and the Reds will counter with Brady Singer (5-9, 4.53 ERA). Cantillo's team is 14-8-0 against the spread in his starts this season. Cantillo's team is 5-3 this season when he starts and they are the moneyline favorite. The Reds have a 12-7-0 ATS record in Singer's 19 starts that had a set spread. The Reds have a 7-10 record in Singer's 17 starts this season when they were the underdog on the moneyline.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (52.8%)

Guardians vs Reds Moneyline

• The Guardians vs Reds moneyline has Cleveland as a -126 favorite, while Cincinnati is a +108 underdog at home.

Guardians vs Reds Spread

• The Guardians are at the Reds and are favored by 1.5 runs on the spread. The Guardians are +130 to cover the runline, with the Reds being -156.

Guardians vs Reds Over/Under

• Guardians versus Reds, on July 29, has an over/under of 9, with the over being -102 and the under -120.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have been victorious in 27, or 50%, of the 54 contests they have been chosen as favorites in this season.
• This season Cleveland has been victorious 13 times in 32 chances when named as a favorite of at least -126 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 49 of their 103 opportunities.
• The Guardians are 50-53-0 against the spread in their 103 games with a line set by sportsbooks this season.
• The Reds have been the underdog on the moneyline 71 total times this season. They've gone 34-37 in those games.
• Cincinnati has gone 20-26 when it has played as a moneyline underdog with odds of +108 or longer (43.5%).
• The Reds have played in 104 games with an over/under set, and have combined with their opponents to go over the total 56 times (56-47-1).
• The Reds are 57-47-0 against the spread this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 95 hits, batting .279 this season with 32 extra-base hits. He has an on-base percentage of .347 and a slugging percentage of .441.
• Among all qualified batters in baseball, he ranks 32nd in batting average, 52nd in on-base percentage, and 63rd in slugging.
• Brayan Rocchio leads Cleveland in slugging percentage (.394) thanks to 27 extra-base hits. He's batting .266 with an on-base percentage of .328.
• Among all qualifying players, he is 52nd in batting average, 79th in on-base percentage and 106th in slugging percentage.
• Jose Ramirez has 69 hits this season and has a slash line of .235/.332/.399.
• Steven Kwan leads Cleveland in OBP (.348) this season, fueled by 83 hits.

Reds Player Leaders

• Sal Stewart has accumulated a slugging percentage of .475, a team-best for the Reds. He's batting .254 with an on-base percentage of .332.
• Including all the qualifying hitters in the big leagues, his batting average places him 75th, his on-base percentage ranks 73rd, and he is 37th in slugging.
• Elly De La Cruz's 96 hits and .351 on-base percentage are both team-highs. He has a batting average of .277 while slugging .499.
• Including all qualifying hitters, he ranks 36th in batting average, 43rd in on-base percentage and 20th in slugging percentage.
• JJ Bleday is batting .231 with 11 doubles, a triple, 18 home runs and 44 walks.
• Nathaniel Lowe has 14 doubles, 12 home runs and 26 walks while batting .257.

Guardians vs Reds Head to Head

• 7/28/2026: 2-0 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/28/2026: 6-5 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/17/2026: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/16/2026: 7-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/15/2026: 7-6 CIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/11/2025: 11-2 CLE (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/10/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)

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