Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 10

Odds updated as of 5:12 p.m.

MLB action on Tuesday includes the Cincinnati Reds taking on the Cleveland Guardians.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Guardians Game Info

• Cincinnati Reds (34-33) vs. Cleveland Guardians (34-31)
• Date: Tuesday, June 10, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSOH

Reds vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-110) | CLE: (-106)
• Spread: CIN: -1.5 (+140) | CLE: +1.5 (-170)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Reds vs Guardians Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 5-1, 2.18 ERA vs Slade Cecconi (Guardians) - 1-2, 4.87 ERA

The Reds will look to Andrew Abbott (5-1) against the Guardians and Slade Cecconi (1-2). Abbott's team is 7-2-0 against the spread in his starts this season. Abbott's team has won 75% of his starts when they are favored on the moneyline (3-1). The Guardians have a 2-2-0 ATS record in Cecconi's four starts with a set spread. The Guardians were named the moneyline underdog for two Cecconi starts this season -- they split the games.

Reds vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (56.8%)

Reds vs Guardians Moneyline

• The moneyline numbers for Reds vs. Guardians reveal Cincinnati as the favorite (-110) and Cleveland as the underdog (-106) despite being the home team.

Reds vs Guardians Spread

• The Guardians are +1.5 on the run line against the Reds. The Guardians are -170 to cover, and the Reds are +140.

Reds vs Guardians Over/Under

• A total of 8.5 runs has been set for the Reds-Guardians contest on June 10, with the over available at -102 and the under at -120.

Bet on Cincinnati Reds vs. Cleveland Guardians on FanDuel today!

Reds vs Guardians Betting Trends

• The Reds have been favorites in 26 games this season and have come away with the win 13 times (50%) in those contests.
• This year Cincinnati has won 13 of 26 games when listed as at least -110 on the moneyline.
• The Reds' games have gone over the total in 27 of their 64 opportunities.
• The Reds have an against the spread mark of 35-29-0 in 64 games with a line this season.
• The Guardians have put together an 18-21 record in games they were listed as the moneyline underdog (winning 46.2% of those games).
• Cleveland is 17-21 (winning 44.7% of its games) when playing as a moneyline underdog of -106 or longer.
• The Guardians have played in 63 games with an over/under set, and have combined with opponents to go over the total 29 times (29-32-2).
• The Guardians have a 30-33-0 record ATS this season (covering 47.6% of the time).

Reds Player Leaders

• Elly De La Cruz has 65 hits, which leads Cincinnati hitters this season, while batting .256 with 25 extra-base hits. He has an on-base percentage of .338 and a slugging percentage of .449.
• Among all qualified hitters in MLB, he ranks 82nd in batting average, 65th in on-base percentage, and 59th in slugging.
• TJ Friedl is slashing .295/.384/.432 this season and leads the Reds with an OPS of .815.
• Among qualifying hitters, he is 19th in batting average, 15th in on-base percentage and 72nd in slugging percentage.
• Gavin Lux is batting .281 with a .393 slugging percentage and 27 RBI this year.
• Jose Trevino has been key for Cincinnati with 38 hits, an OBP of .338 plus a slugging percentage of .512.
• Trevino brings a three-game hitting streak into this game. During his last five outings he is hitting .353 with two doubles, a home run, a walk and an RBI.

Guardians Player Leaders

• Jose Ramirez has totaled 79 hits with a .393 on-base percentage and a .553 slugging percentage, all club-bests for the Guardians. He's batting .333.
• Including all the qualified hitters in the big leagues, his batting average puts him fourth, his on-base percentage is 11th, and he is eighth in slugging.
• Ramirez hopes to build on a nine-game hitting streak in this matchup. During his last 10 outings he is batting .389 with a double, three home runs, seven walks and five RBIs.
• Steven Kwan has 14 doubles, five home runs and 22 walks while batting .309. He's slugging .427 with an on-base percentage of .370.
• His batting average ranks 14th among all qualified players, his on-base percentage is 26th, and he is 78th in slugging.
• Carlos Santana is hitting .256 with six doubles, seven home runs and 32 walks.
• Kyle Manzardo has six doubles, two triples, 11 home runs and 23 walks while batting .203.

Reds vs Guardians Head to Head

• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/12/2024: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/11/2024: 5-3 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/27/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/26/2023: 11-7 CIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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