Guardians vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 8:12 p.m.

The MLB slate on Wednesday includes the Cleveland Guardians facing the Tampa Bay Rays.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Rays Game Info

• Cleveland Guardians (15-15) vs. Tampa Bay Rays (17-11)
• Date: Wednesday, April 29, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Rays.TV

Guardians vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | TB: (+100)
• Spread: CLE: +1.5 (-225) | TB: -1.5 (+184)
• Total: 6.5 -- Over: (-115) | Under: (-105)

Guardians vs Rays Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 4-1, 3.28 ERA vs Drew Rasmussen (Rays) - 2-0, 2.45 ERA

The probable starters are Gavin Williams (4-1) for the Guardians and Drew Rasmussen (2-0) for the Rays. Williams and his team have a record of 5-1-0 against the spread when he starts. Williams' team has won each of the four games he's started as the moneyline favorite. The Rays are 3-2-0 against the spread when Rasmussen starts. The Rays are 2-1 in Rasmussen's three starts this season that they were the underdog on the moneyline.

Guardians vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (55.5%)

Guardians vs Rays Moneyline

• Cleveland is a -118 favorite on the moneyline, while Tampa Bay is a +100 underdog on the road.

Guardians vs Rays Spread

• The Rays are 1.5-run favorites against the spread for this matchup with the Guardians. The Rays are +184 to cover, while the Guardians are -225 to cover as a 1.5-run underdog on the runline.

Guardians vs Rays Over/Under

• The Guardians-Rays contest on April 29 has been given an over/under of 6.5 runs. The over is set at -115 and the under at -105.

Bet on Cleveland Guardians vs. Tampa Bay Rays on FanDuel today!

Guardians vs Rays Betting Trends

• The Guardians have been victorious in seven, or 53.8%, of the 13 contests they have been chosen as favorites in this season.
• This season Cleveland has come away with a win seven times in 13 chances when named as a favorite of at least -118 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 15 of their 30 opportunities.
• The Guardians are 16-14-0 against the spread in their 30 games with a line set by sportsbooks this season.
• The Rays have won seven of the 13 games they were the underdog on the moneyline this season (53.8%).
• When it has played as a moneyline underdog with odds of +100 or longer, Tampa Bay has a record of 5-3 (62.5%).
• In the 28 games bookmakers have set an over/under for the Rays, they have combined with opponents to go over the total 17 times (17-11-0).
• The Rays have a 17-11-0 record against the spread this season (covering 60.7% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland OPS (.803) this season. He has a .229 batting average, an on-base percentage of .354, and a slugging percentage of .450.
• Among qualified hitters in MLB, he is 125th in batting average, 54th in on-base percentage, and 60th in slugging.
• Chase DeLauter is hitting .245 with six doubles, a triple, five home runs and 13 walks. He's slugging .489 with an on-base percentage of .333.
• He ranks 84th in batting average, 86th in on-base percentage and 34th in slugging among qualifying batters.
• DeLauter has picked up at least one hit in three games in a row. In his last five games he is hitting .353 with a double, a walk and an RBI.
• Brayan Rocchio leads Cleveland in slugging percentage (.398) powered by six extra-base hits.
• Angel Martinez leads Cleveland in total hits (24) this season while batting .276 with 10 extra-base hits.

Rays Player Leaders

• Yandy Diaz has accumulated an on-base percentage of .424 and a slugging percentage of .486. Both lead the Rays. He's batting .327.
• Including all the qualifying hitters in MLB, he ranks fifth in batting average, fourth in on-base percentage and 37th in slugging percentage.
• Junior Caminero's 29 hits lead his team. He has a batting average of .259 while slugging .500 with an on-base percentage of .333.
• He is currently 67th in batting average, 86th in on-base percentage and 29th in slugging percentage among all qualified hitters.
• Jonathan Aranda has four doubles, seven home runs and 19 walks while hitting .228.
• Chandler Simpson is batting .309 with two triples and six walks.

Guardians vs Rays Head to Head

• 4/27/2026: 3-2 TB (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2025: 2-1 CLE (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/6/2025: 3-2 CLE (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/5/2025: 7-1 CLE (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2025: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!