Guardians vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 12:11 p.m.

The Cleveland Guardians will take on the Tampa Bay Rays in MLB action on Wednesday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Rays Game Info

• Cleveland Guardians (15-16) vs. Tampa Bay Rays (18-11)
• Date: Wednesday, April 29, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Rays.TV

Guardians vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | TB: (+100)
• Spread: CLE: +1.5 (-230) | TB: -1.5 (+188)
• Total: 6.5 -- Over: (-112) | Under: (-108)

Guardians vs Rays Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 4-1, 3.28 ERA vs Drew Rasmussen (Rays) - 2-0, 2.45 ERA

The Guardians will call on Gavin Williams (4-1) against the Rays and Drew Rasmussen (2-0). Williams' team is 5-1-0 against the spread in his starts this season. Williams' team has won each of the four games he's started as the moneyline favorite. The Rays have a 3-2-0 ATS record in Rasmussen's five starts that had a set spread. The Rays have been the underdog on the moneyline in three of Rasmussen's starts this season, and they went 2-1 in those games.

Guardians vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (55.1%)

Guardians vs Rays Moneyline

• Looking at the moneyline for Guardians-Rays, Cleveland is the favorite at -118, and Tampa Bay is +100 playing on the road.

Guardians vs Rays Spread

• The Rays are 1.5-run favorites against the spread for this matchup with the Guardians. The Rays are +188 to cover, while the Guardians are -230 to cover as a 1.5-run underdog on the runline.

Guardians vs Rays Over/Under

• A combined run total of 6.5 has been set for Guardians-Rays on April 29, with the over at -112 and the under at -108.

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Guardians vs Rays Betting Trends

• The Guardians have been victorious in seven, or 50%, of the 14 contests they have been chosen as favorites in this season.
• Cleveland has a record of 7-7 when favored by -118 or more this year.
• The Guardians and their opponents have gone over in 15 of their 31 games with a total set by sportsbooks this season.
• The Guardians have posted a record of 16-15-0 against the spread this season.
• The Rays have won eight of the 14 games they were the underdog on the moneyline this season (57.1%).
• Tampa Bay has a 6-3 record (winning 66.7% of its games) when it has played as a moneyline underdog of +100 or longer.
• The Rays have played in 29 games with an over/under set, and have combined with their opponents to go over the total 17 times (17-12-0).
• The Rays have an 18-11-0 record ATS this season (covering 62.1% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland in slugging percentage (.434) thanks to 12 extra-base hits. He has a .221 batting average and an on-base percentage of .343.
• Among all qualifying hitters in MLB, his batting average ranks 131st, his on-base percentage ranks 73rd, and he is 72nd in slugging.
• Chase DeLauter has six doubles, a triple, five home runs and 13 walks. He's batting .245 and slugging .480 with an on-base percentage of .330.
• His batting average is 88th among qualified players, his on-base percentage 94th, and his slugging percentage 38th.
• DeLauter enters this matchup looking to extend his four-game hit streak. During his last five outings he is batting .294 with a double, a walk and an RBI.
• Brayan Rocchio leads the Guardians with an OPS of .735. He has a slash line of .263/.346/.389 this season.
• Angel Martinez leads Cleveland in slugging percentage (.511) and total hits (25) this season.

Rays Player Leaders

• Yandy Diaz has a team-high OBP (.419) and slugging percentage (.477). He's batting .324.
• Including all qualifying players in the majors, he ranks seventh in batting average, seventh in on-base percentage and 40th in slugging percentage.
• Junior Caminero leads his team with 29 hits. He has a batting average of .257 while slugging .496 with an on-base percentage of .331.
• Including all qualified hitters, he is 70th in batting average, 92nd in on-base percentage and 35th in slugging percentage.
• Jonathan Aranda is batting .229 with four doubles, seven home runs and 19 walks.
• Chandler Simpson is batting .307 with a double, two triples and seven walks.

Guardians vs Rays Head to Head

• 4/28/2026: 1-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2026: 3-2 TB (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2025: 2-1 CLE (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/6/2025: 3-2 CLE (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/5/2025: 7-1 CLE (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2025: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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