Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 6:12 p.m.

On Monday in MLB, the Cleveland Guardians are up against the Baltimore Orioles.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Guardians vs Orioles Game Info

• Cleveland Guardians (48-50) vs. Baltimore Orioles (44-54)
• Date: Monday, July 21, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MASN2

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-136) | BAL: (+116)
• Spread: CLE: -1.5 (+152) | BAL: +1.5 (-184)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 5-9, 4.21 ERA vs Tomoyuki Sugano (Orioles) - 7-5, 4.44 ERA

The probable starters are Tanner Bibee (5-9) for the Guardians and Tomoyuki Sugano (7-5) for the Orioles. Bibee's team is 10-8-0 against the spread in his starts this season. Bibee's team has won 55.6% of his starts when they are favored on the moneyline (5-4). The Orioles have gone 9-9-0 ATS in Sugano's 18 starts with a set spread. The Orioles are 7-3 in Sugano's 10 starts this season that they were the moneyline underdog.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.4%)

Guardians vs Orioles Moneyline

• The moneyline numbers for Guardians vs. Orioles reveal Cleveland as the favorite (-136) and Baltimore as the underdog (+116) on the road.

Guardians vs Orioles Spread

• The Orioles are at +1.5 on the runline against the Guardians. The Orioles are -184 to cover the spread, and the Guardians are +152.

Guardians vs Orioles Over/Under

• A combined run total of 8.5 has been set for Guardians-Orioles on July 21, with the over at -106 and the under at -114.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have won in 22, or 61.1%, of the 36 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 8-4 in contests when bookmakers favor them by -136 or more on the moneyline.
• The Guardians and their opponents have gone over in 43 of their 96 games with a total set by sportsbooks this season.
• The Guardians are 49-47-0 against the spread in their 96 games that had a posted line this season.
• The Orioles have gone 22-26 in games they were listed as the moneyline underdog (winning 45.8% of those games).
• Baltimore has an 8-11 record (winning 42.1% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Orioles have combined with opponents to hit the over on the total 41 times this season for a 41-52-3 record against the over/under.
• The Orioles have put together a 40-56-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 105 hits and an OBP of .365, plus a team-best slugging percentage of .517. He's batting .295.
• Among qualified hitters, he is eighth in batting average, his on-base percentage ranks 25th, and he is 17th in slugging.
• Steven Kwan has 20 doubles, a triple, six home runs and 33 walks. He's batting .285 and slugging .396 with an on-base percentage of .345.
• Among qualified hitters, his batting average ranks him 26th, his on-base percentage 54th, and his slugging percentage 107th.
• Carlos Santana is batting .228 with a .353 slugging percentage and 42 RBI this year.
• Angel Martinez is batting .246 with a .268 OBP and 37 RBI for Cleveland this season.
• Martinez brings a three-game hitting streak into this matchup. During his last five outings he is hitting .286 with two doubles, a home run and four RBIs.

Orioles Player Leaders

• Gunnar Henderson has a team-best slugging percentage (.461) and paces the Orioles in hits (97). He's batting .280 and with an on-base percentage of .345.
• Including all the qualified hitters in the big leagues, his batting average ranks 35th, his on-base percentage ranks 54th, and he is 51st in slugging.
• Ryan O'Hearn leads his team with a .378 on-base percentage. He has a batting average of .282 while slugging .458.
• Including all qualifying players, his batting average puts him 29th, his on-base percentage ranks 12th, and he is 53rd in slugging.
• Jackson Holliday is hitting .258 with 14 doubles, two triples, 13 home runs and 21 walks.
• Cedric Mullins has 14 doubles, 13 home runs and 32 walks while hitting .218.

Guardians vs Orioles Head to Head

• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/3/2024: 7-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 8-4 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/25/2024: 10-8 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/24/2024: 3-2 CLE (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!