Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 12:11 a.m.

The MLB's Tuesday slate includes the Cleveland Guardians taking on the Washington Nationals.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Nationals Game Info

• Cleveland Guardians (20-14) vs. Washington Nationals (16-19)
• Date: Tuesday, May 6, 2025
• Time: 3:35 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CLEG

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | WSH: (-100)
• Spread: CLE: -1.5 (+140) | WSH: +1.5 (-170)
• Total: 9 -- Over: (-122) | Under: (-100)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 2-3, 4.78 ERA vs Jake Irvin (Nationals) - 2-1, 4.01 ERA

The probable starters are Luis Ortiz (2-3) for the Guardians and Jake Irvin (2-1) for the Nationals. Ortiz and his team are 3-3-0 ATS this season when he starts. Ortiz's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. The Nationals have a 3-4-0 ATS record in Irvin's seven starts with a set spread. The Nationals have a 3-4 record in Irvin's seven starts this season when they were the moneyline underdog.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.6%)

Guardians vs Nationals Moneyline

• Looking at the moneyline for Guardians-Nationals, Cleveland is the favorite at -118, and Washington is -100 playing at home.

Guardians vs Nationals Spread

• The Nationals are +1.5 on the run line against the Guardians. The Nationals are -170 to cover, and the Guardians are +140.

Guardians vs Nationals Over/Under

• An over/under of 9 has been set for Guardians-Nationals on May 6, with the over being -122 and the under -100.

Bet on Cleveland Guardians vs. Washington Nationals on FanDuel today!

Guardians vs Nationals Betting Trends

• The Guardians have been chosen as favorites in 12 games this year and have walked away with the win nine times (75%) in those games.
• This season Cleveland has been victorious six times in eight chances when named as a favorite of at least -118 on the moneyline.
• The Guardians and their opponents have gone over in 18 of their 33 games with a total set by sportsbooks this season.
• The Guardians are 15-18-0 against the spread in their 33 games with a line set by sportsbooks this season.
• The Nationals have been the moneyline underdog 26 total times this season. They've gone 13-13 in those games.
• Washington has a record of 12-12 in games it has played as a moneyline underdog with odds of -100 or longer (50%).
• The Nationals have played in 33 games with an over/under set, and have combined with their opponents to go over the total 17 times (17-16-0).
• The Nationals have put together a 19-14-0 record against the spread this season.

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.850) this season. He has a .333 batting average, an on-base percentage of .384, and a slugging percentage of .467.
• He is fifth in batting average, 24th in on-base percentage, and 44th in slugging among all qualifying hitters in the majors.
• Kwan will look for his fourth straight game with a hit in this contest. During his last five outings he is batting .333 with a double, two walks and an RBI.
• Jose Ramirez has five doubles, five home runs and 10 walks. He's batting .265 and slugging .436 with an on-base percentage of .318.
• Among qualified hitters, he is 58th in batting average, 88th in on-base percentage and 60th in slugging percentage.
• Kyle Manzardo leads Cleveland in total hits (23) this season, and 12 of those have gone for extra bases.
• Carlos Santana has been key for Cleveland with 25 hits, an OBP of .316 plus a slugging percentage of .316.

Nationals Player Leaders

• James Wood has racked up a team-high OBP (.381) and slugging percentage (.545), while pacing the Nationals in hits (36, while batting .273).
• He ranks 50th in batting average, 25th in on-base percentage and 17th in slugging percentage among all qualifying hitters in MLB.
• Wood hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .368 with two doubles and four walks.
• Nathaniel Lowe has seven doubles, six home runs and 14 walks while hitting .254. He's slugging .446 with an on-base percentage of .331.
• Including all qualifying hitters, he is 75th in batting average, 71st in on-base percentage and 54th in slugging percentage.
• Luis Garcia has five doubles, three home runs and eight walks while hitting .234.
• Keibert Ruiz has four doubles, two home runs and seven walks while batting .298.

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