Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 3:12 p.m.

MLB action on Tuesday includes the Cleveland Guardians taking on the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Guardians vs Nationals Game Info

• Cleveland Guardians (20-14) vs. Washington Nationals (16-19)
• Date: Tuesday, May 6, 2025
• Time: 3:35 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CLEG

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | WSH: (-100)
• Spread: CLE: -1.5 (+146) | WSH: +1.5 (-176)
• Total: 9 -- Over: (-122) | Under: (-100)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 2-3, 4.78 ERA vs Jake Irvin (Nationals) - 2-1, 4.01 ERA

The Guardians will give the ball to Luis Ortiz (2-3, 4.78 ERA), who is eyeing win No. 3 on the season, and the Nationals will turn to Jake Irvin (2-1, 4.01 ERA). Ortiz's team is 3-3-0 against the spread this season in his starts. Ortiz's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. The Nationals are 3-4-0 ATS in Irvin's seven starts that had a set spread. The Nationals have been the underdog on the moneyline in seven of Irvin's starts this season, and they went 3-4 in those games.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (55.1%)

Guardians vs Nationals Moneyline

• The Guardians vs Nationals moneyline has Cleveland as a -118 favorite, while Washington is a -100 underdog at home.

Guardians vs Nationals Spread

• The Guardians are at the Nationals and are favored by 1.5 runs on the spread. The Guardians are +146 to cover the runline, with the Nationals being -176.

Guardians vs Nationals Over/Under

• An over/under of 9 has been set for Guardians-Nationals on May 6, with the over being -122 and the under -100.

Bet on Cleveland Guardians vs. Washington Nationals on FanDuel today!

Guardians vs Nationals Betting Trends

• The Guardians have come away with nine wins in the 12 contests they have been listed as the favorites in this season.
• This year Cleveland has won six of eight games when listed as at least -118 on the moneyline.
• Contests with the Guardians have gone over the total set by sportsbooks in 18 of 33 chances this season.
• In 33 games with a line this season, the Guardians have a mark of 15-18-0 against the spread.
• The Nationals have been the moneyline underdog 26 total times this season. They've gone 13-13 in those games.
• Washington has a 12-12 record (winning 50% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Nationals have played in 33 games with an over/under set, and have combined with opponents to go over the total 17 times (17-16-0).
• The Nationals have a 19-14-0 record ATS this season (covering 57.6% of the time).

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.850) this season. He has a .333 batting average, an on-base percentage of .384, and a slugging percentage of .467.
• Among qualified hitters in MLB, he is sixth in batting average, 24th in on-base percentage, and 45th in slugging.
• Kwan hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .333 with a double, two walks and an RBI.
• Jose Ramirez is hitting .265 with five doubles, five home runs and 10 walks, while slugging .436 with an on-base percentage of .318.
• Among qualified batters, his batting average places him 58th, his on-base percentage 87th, and his slugging percentage 60th.
• Kyle Manzardo has 23 hits and is batting .219 this season.
• Carlos Santana has three home runs, 10 RBI and a batting average of .219 this season.

Nationals Player Leaders

• James Wood has 36 hits with a .381 on-base percentage and a .545 slugging percentage, all club-bests for the Nationals. He's batting .273.
• Including all qualified hitters in the big leagues, his batting average puts him 50th, his on-base percentage ranks 26th, and he is 17th in slugging.
• Wood takes a four-game hitting streak into this game. In his last five games he is batting .368 with two doubles and four walks.
• Nathaniel Lowe is hitting .254 with seven doubles, six home runs and 14 walks. He's slugging .446 with an on-base percentage of .331.
• He is currently 75th in batting average, 71st in on-base percentage and 54th in slugging percentage among all qualified batters.
• Luis Garcia is hitting .234 with five doubles, three home runs and eight walks.
• C.J. Abrams has five doubles, two triples, four home runs and four walks while batting .284.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!