Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 4

Odds updated as of 2:12 p.m.

In MLB action on Friday, the Chicago Cubs face the St. Louis Cardinals.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Cardinals Game Info

• Chicago Cubs (52-35) vs. St. Louis Cardinals (47-41)
• Date: Friday, July 4, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: Apple TV+

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-142) | STL: (+120)
• Spread: CHC: -1.5 (+134) | STL: +1.5 (-162)
• Total: 9.5 -- Over: (-104) | Under: (-118)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 5-3, 4.37 ERA vs Miles Mikolas (Cardinals) - 4-5, 4.76 ERA

The probable pitchers are Colin Rea (5-3) for the Cubs and Miles Mikolas (4-5) for the Cardinals. Rea's team is 7-5-0 against the spread in his starts this season. Rea's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 3-3. The Cardinals have an 8-8-0 ATS record in Mikolas' 16 starts that had a set spread. The Cardinals are 6-6 in Mikolas' 12 starts this season that they were the moneyline underdog.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (58.3%)

Cubs vs Cardinals Moneyline

• Chicago is a -142 favorite on the moneyline, while St. Louis is a +120 underdog on the road.

Cubs vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Cubs. The Cardinals are -162 to cover the spread, and the Cubs are +134.

Cubs vs Cardinals Over/Under

• Cubs versus Cardinals, on July 4, has an over/under of 9.5, with the over being -104 and the under -118.

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Cubs vs Cardinals Betting Trends

• The Cubs have won in 40, or 71.4%, of the 56 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 28-9 in contests when oddsmakers favor them by -142 or more on the moneyline.
• The Cubs and their opponents have gone over the total this season in 45 of their 85 opportunities.
• The Cubs have an against the spread mark of 42-43-0 in 85 games with a line this season.
• The Cardinals have been the moneyline underdog 48 total times this season. They've gone 25-23 in those games.
• When it has played as a moneyline underdog with odds of +120 or longer, St. Louis has a 6-11 record (winning only 35.3% of its games).
• The Cardinals have had an over/under set by bookmakers 87 times, and have combined with opponents to go over the total in 44 of those games (44-40-3).
• The Cardinals are 48-39-0 against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .392, plus a team-best slugging percentage of .525. He's batting .287 on the season.
• Among qualified hitters in MLB, his batting average ranks 27th, his on-base percentage ranks sixth, and he is 14th in slugging.
• Pete Crow-Armstrong is hitting .265 with 20 doubles, four triples, 21 home runs and 16 walks, while slugging .536 with an on-base percentage of .302.
• His batting average is 67th among qualified players, his on-base percentage 125th, and his slugging percentage 11th.
• Seiya Suzuki leads Chicago in total hits (87) this season, and 46 of those have gone for extra bases.
• Suzuki heads into this game with three games in a row with at least one hit. During his last five outings he is hitting .300 with a double, a triple, two home runs, two walks and six RBIs.
• Nico Hoerner is batting .285 with a .333 OBP and 35 RBI for Chicago this season.

Cardinals Player Leaders

• Brendan Donovan has accumulated a team-best OBP (.364) and slugging percentage (.421). He's batting .293.
• Including all qualified players, he is 17th in batting average, while his on-base percentage is 29th and he is 80th in slugging.
• Nolan Arenado has 13 doubles, a triple, 10 home runs and 24 walks while hitting .247. He's slugging .395 with an on-base percentage of .306.
• Including all qualifying hitters, his batting average places him 109th, his on-base percentage ranks 116th, and he is 108th in slugging.
• Willson Contreras is hitting .248 with 19 doubles, 11 home runs and 29 walks.
• Lars Nootbaar is batting .226 with 13 doubles, 11 home runs and 46 walks.

Cubs vs Cardinals Head to Head

• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 6-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/14/2024: 8-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/13/2024: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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