Guardians vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for June 26

Odds updated as of 2:12 a.m.

The Friday schedule in MLB includes a matchup between the Cleveland Guardians and the Seattle Mariners.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Mariners Game Info

• Cleveland Guardians (42-39) vs. Seattle Mariners (41-41)
• Date: Friday, June 26, 2026
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Mariners.TV

Guardians vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-112) | SEA: (-104)
• Spread: CLE: +1.5 (-200) | SEA: -1.5 (+164)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Guardians vs Mariners Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 6-3, 4.05 ERA vs Luis Castillo (Mariners) - 2-6, 5.22 ERA

The Guardians will look to Joey Cantillo (6-3) against the Mariners and Luis Castillo (2-6). Cantillo's team is 12-4-0 against the spread this season in his starts. Cantillo's team has won 66.7% of his starts when they are favored on the moneyline (4-2). When Castillo starts, the Mariners are 3-9-0 against the spread. The Mariners are 1-2 in Castillo's three starts this season that they were the moneyline underdog.

Guardians vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (57.4%)

Guardians vs Mariners Moneyline

• The Guardians vs Mariners moneyline has Cleveland as a -112 favorite, while Seattle is a -104 underdog on the road.

Guardians vs Mariners Spread

• The Mariners are 1.5-run favorites against the spread for this matchup with the Guardians. The Mariners are +164 to cover, while the Guardians are -200 to cover as a 1.5-run underdog on the runline.

Guardians vs Mariners Over/Under

• The over/under for Guardians-Mariners on June 26 is 7.5. The over is -105, and the under is -115.

Bet on Cleveland Guardians vs. Seattle Mariners on FanDuel today!

Guardians vs Mariners Betting Trends

• The Guardians have been favorites in 41 games this season and have come away with the win 21 times (51.2%) in those contests.
• This season Cleveland has been victorious 21 times in 40 chances when named as a favorite of at least -112 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 38 of their 77 opportunities.
• The Guardians have posted a record of 39-38-0 against the spread this season.
• The Mariners are 2-5 in games they were listed as the moneyline underdog (winning 28.6% of those games).
• When playing as a moneyline underdog with odds of -104 or longer, Seattle has gone 1-3 (25%).
• The Mariners have combined with opponents to hit the over on the total 38 times this season for a 38-40-3 record against the over/under.
• The Mariners have put together a 29-52-0 record against the spread this season (covering just 35.8% of the time).

Guardians Player Leaders

• Brayan Rocchio leads Cleveland with an OBP of .344, plus a team-best slugging percentage of .388. He's batting .269 on the season.
• Among all qualifying hitters, he ranks 47th in batting average, his on-base percentage ranks 58th, and he is 107th in slugging.
• Travis Bazzana is hitting .261 with 11 doubles, a triple, seven home runs and 26 walks. He's slugging .446 with an on-base percentage of .357.
• Steven Kwan has 53 hits this season and has a slash line of .211/.322/.259.
• Kwan has logged a hit or more in two games in a row. During his last five outings he is batting .231 with a double and two walks.
• Kyle Manzardo is batting .233 with a .328 OBP and 27 RBI for Cleveland this season.

Mariners Player Leaders

• Julio Rodriguez has a .423 slugging percentage, which leads the Mariners. He's batting .247 with an on-base percentage of .308.
• Including all the qualified hitters in MLB, his batting average ranks 91st, his on-base percentage ranks 121st, and he is 84th in slugging.
• Randy Arozarena's 77 hits and .371 OBP both pace his team. He has a batting average of .284 while slugging .435.
• Including all qualifying players, he is 28th in batting average, 25th in on-base percentage and 73rd in slugging percentage.
• Josh Naylor is batting .258 with 10 doubles, eight home runs and 25 walks.
• Cole Young has 12 doubles, a triple, seven home runs and 22 walks while hitting .251.

Guardians vs Mariners Head to Head

• 3/29/2026: 8-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 3/28/2026: 6-5 CLE (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 3/27/2026: 5-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 3/26/2026: 6-4 CLE (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 8/31/2025: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/30/2025: 4-3 CLE (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2025: 5-4 CLE (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/15/2025: 6-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/14/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/13/2025: 7-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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