Guardians vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 14

Odds updated as of 7:11 p.m.

MLB action on Tuesday includes the Cleveland Guardians facing the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Cardinals Game Info

• Cleveland Guardians (10-7) vs. St. Louis Cardinals (8-8)
• Date: Tuesday, April 14, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CleGuardians.TV

Guardians vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | STL: (+108)
• Spread: CLE: -1.5 (+136) | STL: +1.5 (-164)
• Total: 9 -- Over: (-104) | Under: (-118)

Guardians vs Cardinals Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 1-0, 2.45 ERA vs Michael McGreevy (Cardinals) - 1-1, 2.16 ERA

The probable pitchers are Joey Cantillo (1-0) for the Guardians and Michael McGreevy (1-1) for the Cardinals. Cantillo and his team have covered in each of his three starts with a spread this season. This will be Cantillo's first game as the moneyline favorite this season. The Cardinals have a 2-1-0 ATS record in McGreevy's three starts with a set spread. The Cardinals were the underdog on the moneyline for two McGreevy starts this season -- they split the games.

Guardians vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.4%)

Guardians vs Cardinals Moneyline

• The Guardians vs Cardinals moneyline has Cleveland as a -126 favorite, while St. Louis is a +108 underdog at home.

Guardians vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Guardians. The Cardinals are -164 to cover, and the Guardians are +136.

Guardians vs Cardinals Over/Under

• The over/under for Guardians-Cardinals on April 14 is 9. The over is -104, and the under is -118.

Bet on Cleveland Guardians vs. St. Louis Cardinals on FanDuel today!

Guardians vs Cardinals Betting Trends

• The Guardians have been chosen as favorites in three games this year and have walked away with the win two times (66.7%) in those games.
• These are the best odds of a victory sportsbooks have given Cleveland this season, with a -126 moneyline set for this game.
• The Guardians and their opponents have hit the over in eight of their 17 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 11-6-0 against the spread this season.
• The Cardinals have been the moneyline underdog 14 total times this season. They've gone 7-7 in those games.
• St. Louis has a 5-4 record (winning 55.6% of its games) when playing as a moneyline underdog of +108 or longer.
• The Cardinals have played in 16 games with an over/under set, and have combined with opponents to go over the total nine times (9-6-1).
• The Cardinals have gone 7-9-0 against the spread this season.

Guardians Player Leaders

• Chase DeLauter has 15 hits, which leads Cleveland hitters this season, while batting .300 with nine extra-base hits. He has an on-base percentage of .379 and a slugging percentage of .680.
• He is 41st in batting average, 42nd in on-base percentage, and fifth in slugging among all qualifying batters in baseball.
• DeLauter has picked up at least one hit in four straight games. During his last five outings he is hitting .333 with four doubles, four walks and three RBIs.
• Jose Ramirez is hitting .200 with four doubles, two home runs and nine walks. He's slugging .354 with an on-base percentage of .297.
• Among qualifying batters, he ranks 141st in batting average, 128th in on-base percentage and 110th in slugging percentage.
• Ramirez takes a three-game streak with at least one hit into this matchup. During his last five outings he is hitting .350 with two doubles, a home run, four walks and two RBIs.
• Angel Martinez has 15 hits this season and a team-best OBP of .385.
• Steven Kwan leads Cleveland with a slugging percentage of .339, fueled by three extra-base hits.

Cardinals Player Leaders

• Jordan Walker has put up a team-best OBP (.394) and slugging percentage (.767), and leads the Cardinals in hits (20, while batting .333).
• He is 11th in batting average, 31st in on-base percentage and first in slugging percentage among all qualifying batters in the majors.
• Walker brings a nine-game hitting streak into this game. During his last 10 outings he is batting .366 with seven home runs, three walks and 12 RBIs.
• Alec Burleson has three doubles, two home runs and 11 walks while hitting .271. He's slugging .424 with an on-base percentage of .380.
• His batting average is 64th among all qualified players, his on-base percentage ranks 40th, and he is 72nd in slugging.
• JJ Wetherholt is batting .213 with a double, a home run and 10 walks.
• Ivan Herrera has three doubles and 14 walks while hitting .193.

Guardians vs Cardinals Head to Head

• 4/13/2026: 9-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/29/2025: 7-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/28/2025: 9-6 STL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/22/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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