Guardians vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for May 12

Odds updated as of 1:11 a.m.

The MLB's Tuesday schedule includes the Cleveland Guardians facing the Los Angeles Angels.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Angels Game Info

• Cleveland Guardians (22-21) vs. Los Angeles Angels (16-26)
• Date: Tuesday, May 12, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and ABTV

Guardians vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | LAA: (+110)
• Spread: CLE: -1.5 (+150) | LAA: +1.5 (-182)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Guardians vs Angels Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 2-4, 6.15 ERA vs Walbert Urena (Angels) - 1-3, 3.22 ERA

The Guardians will give the nod to Slade Cecconi (2-4, 6.15 ERA), who is eyeing win No. 3 on the season, and the Angels will counter with Walbert Urena (1-3, 3.22 ERA). Cecconi's team is 3-5-0 against the spread this season in his starts. Cecconi's team lost his only start as a favorite this season. When Urena starts, the Angels are 3-1-0 against the spread. The Angels are 1-3 in Urena's four starts this season that they were the moneyline underdog.

Guardians vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50%)

Guardians vs Angels Moneyline

• Los Angeles is the underdog, +110 on the moneyline, while Cleveland is a -130 favorite at home.

Guardians vs Angels Spread

• The Guardians are hosting the Angels and are favored by 1.5 runs on the spread. The Guardians are +150 to cover the runline, with the Angels being -182.

Guardians vs Angels Over/Under

• A combined run total of 8.5 has been set for Guardians-Angels on May 12, with the over at -105 and the under at -115.

Bet on Cleveland Guardians vs. Los Angeles Angels on FanDuel today!

Guardians vs Angels Betting Trends

• The Guardians have come away with 10 wins in the 20 contests they have been listed as the favorites in this season.
• Cleveland has a record of 5-6 in contests when bookmakers favor them by -130 or more on the moneyline.
• The Guardians and their opponents have gone over in 22 of their 41 games with a total set by sportsbooks this season.
• The Guardians are 22-19-0 against the spread in their 41 games with a line set by sportsbooks this season.
• The Angels have gone 11-19 in games they were the underdog on the moneyline (winning 36.7% of those games).
• Los Angeles is 9-14 (winning just 39.1% of its games) when it has played as a moneyline underdog of +110 or longer.
• In the 41 games bookmakers have set an over/under for the Angels, they have combined with opponents to go over the total 19 times (19-22-0).
• The Angels are 20-21-0 against the spread this season.

Guardians Player Leaders

• Jose Ramirez has eight doubles, six home runs and 31 walks while hitting .215. He has an on-base percentage of .344 and a slugging percentage of .380.
• Among qualifying batters in the majors, he ranks 138th in batting average, 67th in on-base percentage, and 108th in slugging.
• Chase DeLauter leads Cleveland with 40 hits and an OBP of .376, plus a team-best slugging percentage of .511. He's batting .292.
• Among qualifying hitters, his batting average places him 28th, his on-base percentage 29th, and his slugging percentage 24th.
• Brayan Rocchio has 38 hits this season and has a slash line of .277/.357/.380.
• Rocchio has recorded at least one base hit in two games in a row. During his last five outings he is batting .421 with a double, two walks and two RBIs.
• Steven Kwan has one home run, nine RBI and a batting average of .204 this season.

Angels Player Leaders

• Mike Trout has put up a team-high OBP (.414), and leads the Angels in hits (36). He's batting .248 and slugging.
• Including all qualifying hitters in the majors, his batting average puts him 89th, his on-base percentage ranks sixth, and he is 27th in slugging.
• Zach Neto has nine doubles, a triple, six home runs and 24 walks while hitting .222. He's slugging .395 with an on-base percentage of .325.
• His batting average is 129th among all qualified players, his on-base percentage is 99th, and he is 92nd in slugging.
• Jorge Soler has six doubles, eight home runs and 18 walks while hitting .226.
• Nolan Schanuel has 10 doubles, three home runs and 11 walks while batting .257.

Guardians vs Angels Head to Head

• 5/11/2026: 7-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/1/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 5/31/2025: 7-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 4-1 LAA (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/6/2025: 6-2 LAA (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/5/2025: 10-4 LAA (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/4/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/25/2024: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/24/2024: 10-4 CLE (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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