Guardians vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for May 12

Odds updated as of 6:11 p.m.

The Tuesday slate in MLB includes a matchup between the Cleveland Guardians and the Los Angeles Angels.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Angels Game Info

• Cleveland Guardians (22-21) vs. Los Angeles Angels (16-26)
• Date: Tuesday, May 12, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and ABTV

Guardians vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-138) | LAA: (+118)
• Spread: CLE: -1.5 (+146) | LAA: +1.5 (-178)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Guardians vs Angels Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 2-4, 6.15 ERA vs Walbert Urena (Angels) - 1-3, 3.22 ERA

The probable pitchers are Slade Cecconi (2-4) for the Guardians and Walbert Urena (1-3) for the Angels. When Cecconi starts, his team is 3-5-0 against the spread this season. Cecconi's team lost his only start as a favorite this season. The Angels have a 3-1-0 record against the spread in Urena's starts. The Angels have a 1-3 record in Urena's four starts this season when they were the moneyline underdog.

Guardians vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.7%)

Guardians vs Angels Moneyline

• Cleveland is the favorite, -138 on the moneyline, while Los Angeles is a +118 underdog on the road.

Guardians vs Angels Spread

• The Guardians are favored by 1.5 runs at home against the Angels. The Guardians are +146 to cover the spread, while the Angels are -178.

Guardians vs Angels Over/Under

• A total of 8.5 runs has been set for the Guardians-Angels game on May 12, with the over available at -114 and the under at -106.

Bet on Cleveland Guardians vs. Los Angeles Angels on FanDuel today!

Guardians vs Angels Betting Trends

• The Guardians have come away with 10 wins in the 20 contests they have been listed as the favorites in this season.
• Cleveland has a record of 3-3 in contests when sportsbooks favor them by -138 or more on the moneyline.
• The Guardians and their opponents have gone over in 22 of their 41 games with a total set by sportsbooks this season.
• In 41 games with a line this season, the Guardians have a mark of 22-19-0 against the spread.
• The Angels have an 11-19 record in games they were listed as the moneyline underdog (winning 36.7% of those games).
• Los Angeles has a 9-11 record (winning 45% of its games) when it has played as a moneyline underdog of +118 or longer.
• The Angels have combined with opponents to hit the over on the total 19 times this season for a 19-22-0 record against the over/under.
• The Angels have a 20-21-0 record against the spread this season (covering 48.8% of the time).

Guardians Player Leaders

• Jose Ramirez is hitting .215 with eight doubles, six home runs and 31 walks. He has an on-base percentage of .344 while slugging .380.
• Among qualifying batters in MLB, his batting average ranks 138th, his on-base percentage ranks 69th, and he is 108th in slugging.
• Chase DeLauter has 40 hits and an OBP of .376 to go with a slugging percentage of .511. All three of those stats rank first among Cleveland hitters this season. He's batting .292.
• He is 29th in batting average, 29th in on-base percentage and 24th in slugging in the majors.
• Brayan Rocchio has collected 38 base hits, an OBP of .357 and a slugging percentage of .380 this season.
• Rocchio takes a two-game hitting streak into this matchup. In his last five games he is batting .421 with a double, two walks and two RBIs.
• Steven Kwan has one home run, nine RBI and a batting average of .204 this season.

Angels Player Leaders

• Mike Trout has put up an on-base percentage of .414 and has 36 hits, both team-best numbers for the Angels. He's batting .248 and slugging .510.
• He ranks 90th in batting average, sixth in on-base percentage and 27th in slugging percentage among all qualified batters in the majors.
• Zach Neto is batting .222 with nine doubles, a triple, six home runs and 24 walks. He's slugging .395 with an on-base percentage of .325.
• He ranks 129th in batting average, 100th in on-base percentage and 92nd in slugging percentage in the big leagues.
• Nolan Schanuel has 10 doubles, three home runs and 11 walks while hitting .257.
• Jorge Soler is hitting .226 with six doubles, eight home runs and 18 walks.

Guardians vs Angels Head to Head

• 5/11/2026: 7-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/1/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 5/31/2025: 7-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 4-1 LAA (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/6/2025: 6-2 LAA (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/5/2025: 10-4 LAA (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/4/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/25/2024: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/24/2024: 10-4 CLE (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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