Grizzlies vs. Spurs Prediction, Odds, Picks, Best Bets for March 25

Grizzlies vs. Spurs Game Info

• Date: Wednesday, March 25, 2026
• Time: 8 p.m. ET
• Venue: FedExForum -- Memphis, Tennessee
• Coverage: FDSSE, FDSSW, and WMC-TV

The San Antonio Spurs (54-18) are heavy favorites (-16.5) as they look to extend a four-game road winning streak when they take on the Memphis Grizzlies (24-47) on Wednesday, March 25, 2026 at FedExForum. The matchup airs at 8 p.m. ET on FDSSE, FDSSW, and WMC-TV. The matchup's over/under is set at 234.5.

Grizzlies vs. Spurs Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Grizzlies vs. Spurs Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Spurs win (70.7%)

Grizzlies vs. Spurs Betting Trends

• The Spurs are 37-30-4 against the spread this season.
• The Grizzlies have played 71 games, with 32 wins against the spread.
• Games involving the Spurs have hit the over 32 times out of 71 chances this season.
• Grizzlies games this year have eclipsed the over/under 34 times in 71 opportunities (47.9%).
• San Antonio has done a better job covering the spread when playing on the road (21-15-1) than it has at home (16-15-3).
• When playing at home, the Spurs exceed the over/under 45.7% of the time (16 of 35 games). They've hit the over in 43.2% of away games (16 of 37 contests).
• This year, Memphis is 16-18-0 at home against the spread (.471 winning percentage). On the road, it is 16-19-2 ATS (.432).
• Looking at the over/under, Grizzlies games have finished over 18 of 34 times at home (52.9%), and 16 of 37 away (43.2%).

Spurs Leaders

• Victor Wembanyama averages 24.3 points, 11.2 rebounds and 3 assists.
• Stephon Castle is averaging 16.5 points, 7.1 assists and 5.1 rebounds.
• Keldon Johnson is averaging 13 points, 5.4 boards and 1.3 assists. Defensively, he averages 0.6 steals and 0.1 blocked shots.
• Julian Champagnie is averaging 11.1 points, 5.7 rebounds and 1.5 assists.
• Devin Vassell is averaging 14.1 points, 3.8 boards and 2.5 assists.

Grizzlies Leaders

• Per game, Cam Spencer provides the Grizzlies 11.2 points, 2.6 rebounds and 5.4 assists. He also averages 0.7 steals and 0.1 blocks.
• Cedric Coward's numbers on the season are 13.4 points, 6.2 boards and 2.8 assists per game. He is sinking 46.4% of his shots from the field and 33.6% from beyond the arc, with an average of 1.5 treys.
• The Grizzlies get 11.8 points per game from GG Jackson, plus 4.2 rebounds and 1.4 assists.
• The Grizzlies receive 7.3 points per game from Walter Clayton Jr., plus 2 boards and 3.9 assists.
• The Grizzlies receive 7.4 points per game from Taylor Hendricks, plus 3.6 rebounds and 1 assists.

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