Giants vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 3:11 p.m.

In MLB action on Saturday, the San Francisco Giants face the Boston Red Sox.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs Red Sox Game Info

• San Francisco Giants (42-34) vs. Boston Red Sox (40-37)
• Date: Saturday, June 21, 2025
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and NESN

Giants vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-122) | BOS: (+104)
• Spread: SF: -1.5 (+176) | BOS: +1.5 (-215)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Giants vs Red Sox Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 4-5, 4.11 ERA vs Brayan Bello (Red Sox) - 3-1, 3.49 ERA

The probable pitchers are Landen Roupp (4-5) for the Giants and Brayan Bello (3-1) for the Red Sox. Roupp and his team are 5-9-0 ATS this season when he starts. Roupp's team has a record of 3-2 this season when he starts and they are the favorite on the moneyline. The Red Sox are 7-4-0 ATS in Bello's 11 starts with a set spread. The Red Sox have a 1-3 record in Bello's four starts this season when they were the moneyline underdog.

Giants vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (54.7%)

Giants vs Red Sox Moneyline

• Boston is the underdog, +104 on the moneyline, while San Francisco is a -122 favorite at home.

Giants vs Red Sox Spread

• The Red Sox are +1.5 on the run line against the Giants. The Red Sox are -215 to cover, and the Giants are +176.

Giants vs Red Sox Over/Under

• Giants versus Red Sox, on June 21, has an over/under of 7.5, with the over being -105 and the under -115.

Bet on San Francisco Giants vs. Boston Red Sox on FanDuel today!

Giants vs Red Sox Betting Trends

• The Giants have won in 28, or 57.1%, of the 49 contests they have been named as odds-on favorites in this year.
• San Francisco has a record of 23-17 when favored by -122 or more this year.
• The Giants' games have gone over the total in 34 of their 76 opportunities.
• The Giants have posted a record of 34-42-0 against the spread this season.
• The Red Sox have a 13-13 record in games they were the underdog on the moneyline (winning 50% of those games).
• In games it has played as a moneyline underdog with odds of +104 or longer, Boston has a 12-7 record (winning 63.2% of its games).
• The Red Sox have played in 77 games with a set over/under, and have combined with their opponents to go over the total 35 times (35-40-2).
• The Red Sox have covered 53.2% of their games this season, going 41-36-0 ATS.

Giants Player Leaders

• Rafael Devers leads San Francisco with 77 hits and an OBP of .395 this season. He has a .267 batting average and a slugging percentage of .490.
• Among all qualifying hitters, he is 56th in batting average, his on-base percentage ranks seventh, and he is 24th in slugging.
• Jung Hoo Lee is hitting .255 with 17 doubles, five triples, six home runs and 26 walks. He's slugging .415 with an on-base percentage of .319.
• His batting average is 80th among qualified players, his on-base percentage 99th, and his slugging percentage 94th.
• Heliot Ramos leads San Francisco in slugging percentage (.463) powered by 26 extra-base hits.
• Wilmer Flores is batting .255 with a .325 OBP and 54 RBI for San Francisco this season.
• Flores takes a two-game hitting streak into this game. During his last five outings he is hitting .154 with a double, a walk and three RBIs.

Red Sox Player Leaders

• Jarren Duran has accumulated a team-best .412 slugging percentage. He's batting .260 with an on-base percentage of .313.
• Including all the qualified hitters in the big leagues, his batting average is 71st, his on-base percentage ranks 109th, and he is 96th in slugging.
• Wilyer Abreu has collected 53 hits with a .324 OBP to lead his team in both. He has a batting average of .250 while slugging .476.
• Including all qualified hitters, his batting average puts him 93rd, his on-base percentage ranks 89th, and he is 35th in slugging.
• Ceddanne Rafaela is batting .255 with 12 doubles, two triples, seven home runs and 14 walks.
• Carlos Narvaez is batting .270 with 15 doubles, six home runs and 26 walks.

Giants vs Red Sox Head to Head

• 6/20/2025: 7-5 BOS (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/2/2024: 3-1 SF (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/1/2024: 6-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/30/2024: 4-0 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/30/2023: 4-3 SF (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/29/2023: 3-2 SF (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/28/2023: 3-2 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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