Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 9:11 a.m.

The MLB's Saturday slate includes the Houston Astros taking on the Los Angeles Angels.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Astros vs Angels Game Info

• Houston Astros (44-32) vs. Los Angeles Angels (36-39)
• Date: Saturday, June 21, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-112) | LAA: (-104)
• Spread: HOU: -1.5 (+138) | LAA: +1.5 (-166)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Brandon Walter (Astros) - 0-0, 1.53 ERA vs José Soriano (Angels) - 4-5, 3.54 ERA

The Astros will give the ball to Brandon Walter and the Angels will turn to Jose Soriano (4-5, 3.54 ERA). Walter's team is 2-1-0 against the spread in his starts this season. Walter's team won his only start as a favorite this season. The Angels have a 4-11-0 ATS record in Soriano's 15 starts with a set spread. The Angels have been the underdog on the moneyline in 10 of Soriano's starts this season, and they went 4-6 in those games.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56.5%)

Astros vs Angels Moneyline

• Houston is a -112 favorite on the moneyline, while Los Angeles is a -104 underdog at home.

Astros vs Angels Spread

• The Astros are at the Angels and are favored by 1.5 runs (+138 to cover) on the runline. Los Angeles is -166 to cover.

Astros vs Angels Over/Under

• A total of 8.5 runs has been set for the Astros-Angels game on June 21, with the over available at -100 and the under at -122.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have been victorious in 30, or 57.7%, of the 52 contests they have been chosen as favorites in this season.
• This season Houston has come away with a win 29 times in 51 chances when named as a favorite of at least -112 on the moneyline.
• The Astros and their opponents have gone over in 29 of their 75 games with a total set by sportsbooks this season.
• The Astros are 40-35-0 against the spread in their 75 games that had a posted line this season.
• The Angels have won 28 of the 60 games they were listed as the moneyline underdog this season (46.7%).
• Los Angeles is 26-31 (winning 45.6% of its games) when it has played as a moneyline underdog of -104 or longer.
• In the 74 games oddsmakers have set an over/under for the Angels, they have combined with opponents to go over the total 37 times (37-35-2).
• The Angels have a 38-36-0 record against the spread this season.

Astros Player Leaders

• Jeremy Pena has 97 hits and an OBP of .383 to go with a slugging percentage of .486. All three of those stats lead Houston hitters this season. He has a .328 batting average, as well.
• Among all qualified hitters in baseball, his batting average ranks fourth, his on-base percentage ranks 13th, and he is 27th in slugging.
• Pena hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .364 with a home run, two walks and four RBIs.
• Isaac Paredes is batting .253 with 10 doubles, a triple, 16 home runs and 41 walks, while slugging .476 with an on-base percentage of .360.
• Among all qualifying players, he ranks 87th in batting average, 32nd in on-base percentage and 35th in slugging percentage.
• Jose Altuve is batting .269 with a .430 slugging percentage and 34 RBI this year.
• Jake Meyers has three home runs, 19 RBI and a batting average of .307 this season.
• Meyers has hit safely in eight straight games. During his last 10 games he is hitting .342 with two doubles, four walks and three RBIs.

Angels Player Leaders

• Nolan Schanuel has accumulated a team-best OBP (.363) and slugging percentage (.390). He's batting .273.
• Including all the qualified players in the majors, he is 45th in batting average, 29th in on-base percentage and 116th in slugging percentage.
• Taylor Ward is hitting .209 with 13 doubles, a triple, 19 home runs and 24 walks. He's slugging .465 with an on-base percentage of .269.
• His batting average ranks 151st among all qualified players, his on-base percentage ranks 154th, and he is 42nd in slugging.
• Zach Neto is batting .263 with 13 doubles, a triple, 10 home runs and 11 walks.
• Jo Adell has collected 47 hits to lead his team.

Astros vs Angels Head to Head

• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/22/2024: 9-8 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 9/21/2024: 10-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/20/2024: 9-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/19/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/15/2024: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/14/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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