Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 9:11 p.m.

The MLB schedule on Saturday includes the Los Angeles Angels facing the Houston Astros.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Angels vs Astros Game Info

• Los Angeles Angels (36-39) vs. Houston Astros (44-32)
• Date: Saturday, June 21, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Angels vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-116) | HOU: (-102)
• Spread: LAA: +1.5 (-200) | HOU: -1.5 (+164)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Angels vs Astros Probable Starting Pitchers

Probable Pitchers: José Soriano (Angels) - 4-5, 3.54 ERA vs Brandon Walter (Astros) - 0-0, 1.53 ERA

The probable starters are Jose Soriano (4-5) for the Angels and Brandon Walter for the Astros. When Soriano starts, his team is 4-11-0 against the spread this season. Soriano's team is 2-3 this season when he starts and they are the moneyline favorite. When Walter starts, the Astros have gone 2-1-0 against the spread. The Astros were the underdog on the moneyline for two Walter starts this season -- they lost both.

Angels vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56.5%)

Angels vs Astros Moneyline

• Looking at the moneyline for Astros-Angels, Houston is the underdog at -102, and Los Angeles is -116 playing at home.

Angels vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Angels. The Astros are +164 to cover, while the Angels are -200 to cover as a 1.5-run underdog on the runline.

Angels vs Astros Over/Under

• Angels versus Astros, on June 21, has an over/under of 8.5, with the over being -102 and the under -120.

Bet on Los Angeles Angels vs. Houston Astros on FanDuel today!

Angels vs Astros Betting Trends

• The Angels have been chosen as favorites in 14 games this year and have walked away with the win eight times (57.1%) in those games.
• Los Angeles has a record of 8-5 in contests when oddsmakers favor them by -116 or more on the moneyline.
• The Angels and their opponents have hit the over in 37 of their 74 games with a total set by oddsmakers this season.
• The Angels have an against the spread record of 38-36-0 in 74 games with a line this season.
• The Astros have won 59.1% of the games this season they were the moneyline underdog (13-9).
• Houston is 8-8 (winning 50% of its games) when playing as a moneyline underdog of -102 or longer.
• The Astros have played in 75 games with a set over/under, and have combined with opponents to go over the total 29 times (29-44-2).
• The Astros are 40-35-0 ATS this season.

Angels Player Leaders

• Nolan Schanuel has an OPS of .753, fueled by an OBP of .363 to go with a slugging percentage of .390. He has a .273 batting average, as well.
• Among all qualified hitters in the majors, he ranks 44th in batting average, 29th in on-base percentage, and 115th in slugging.
• Taylor Ward has 13 doubles, a triple, 19 home runs and 24 walks. He's batting .209 and slugging .465 with an on-base percentage of .269.
• Among all qualifying hitters, he ranks 152nd in batting average, 156th in on-base percentage and 43rd in slugging percentage.
• Ward has picked up a hit in two games in a row. During his last five outings he is hitting .150 with a home run, two walks and three RBIs.
• Zach Neto has 61 hits this season and has a slash line of .263/.306/.457.
• Jo Adell has 47 hits, which ranks first among Los Angeles hitters this season, while batting .222 with 23 extra-base hits.
• Adell enters this matchup on a three-game hitting streak. In his last five games he is hitting .167 with three home runs, two walks and four RBIs.

Astros Player Leaders

• Jeremy Pena has accumulated an on-base percentage of .383, a slugging percentage of .486, and has 97 hits, all club-highs for the Astros (while batting .328).
• Including all the qualifying hitters in MLB, he is fourth in batting average, 13th in on-base percentage and 28th in slugging percentage.
• Pena hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .364 with a home run, two walks and four RBIs.
• Isaac Paredes has 10 doubles, a triple, 16 home runs and 41 walks while hitting .253. He's slugging .476 with an on-base percentage of .360.
• His batting average ranks 87th among all qualified players, his on-base percentage is 31st, and he is 38th in slugging.
• Jose Altuve has 10 doubles, 12 home runs and 21 walks while batting .269.
• Jake Meyers has 13 doubles, a triple, three home runs and 23 walks while batting .307.

Angels vs Astros Head to Head

• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/22/2024: 9-8 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 9/21/2024: 10-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/20/2024: 9-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/19/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/15/2024: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/14/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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