Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 9:11 p.m.

The MLB slate on Saturday includes the Cleveland Guardians taking on the Athletics.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Guardians vs Athletics Game Info

• Cleveland Guardians (37-37) vs. Athletics (32-46)
• Date: Saturday, June 21, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and CLEG

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | OAK: (+114)
• Spread: CLE: -1.5 (+116) | OAK: +1.5 (-140)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 3-8, 4.64 ERA vs Mitch Spence (Athletics) - 2-1, 3.50 ERA

The probable starters are Luis Ortiz (3-8) for the Guardians and Mitch Spence (2-1) for the Athletics. Ortiz's team is 5-9-0 against the spread in his starts this season. Ortiz's team has won 33.3% of his starts when they are favored on the moneyline (2-4). The Athletics covered each of Spence's three starts that had a set spread. The Athletics have a 2-1 record in Spence's three starts this season when they were the moneyline underdog.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (55.6%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -134 favorite, while the Athletics are a +114 underdog at home.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +116 to cover, while the Athletics are -140 to cover.

Guardians vs Athletics Over/Under

• An over/under of 9.5 has been set for Guardians-Athletics on June 21, with the over being -100 and the under -122.

Bet on Cleveland Guardians vs. Athletics on FanDuel today!

Guardians vs Athletics Betting Trends

• The Guardians have come away with 14 wins in the 24 contests they have been listed as the favorites in this season.
• This year, the Guardians have won seven of 10 games when listed as at least -134 or better on the moneyline.
• The Guardians and their opponents have hit the over in 31 of their 72 games with a total this season.
• The Guardians are 36-36-0 against the spread in their 72 games that had a posted line this season.
• The Athletics have been the moneyline underdog 58 total times this season. They've gone 21-37 in those games.
• The Athletics have gone 11-31 when they have played as a moneyline underdog with odds of +114 or longer (26.2%).
• The Athletics have played in 78 games with an over/under set, and have combined with their opponents to go over the total 43 times (43-32-3).
• The Athletics have a 38-40-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 86 hits and an OBP of .378, plus a team-best slugging percentage of .528. He's batting .317.
• Among qualified batters in the majors, his batting average ranks eighth, his on-base percentage ranks 19th, and he is 12th in slugging.
• Ramirez hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .158 with a double, a walk and an RBI.
• Steven Kwan has 15 doubles, six home runs and 25 walks. He's batting .299 and slugging .420 with an on-base percentage of .362.
• He ranks 17th in batting average, 30th in on-base percentage and 89th in slugging in the majors.
• Kwan takes a two-game streak with at least one hit into this one. In his last five games he is batting .250 with a double and two walks.
• Carlos Santana is batting .241 with a .363 slugging percentage and 36 RBI this year.
• Kyle Manzardo is batting .212 with a .295 OBP and 31 RBI for Cleveland this season.

Athletics Player Leaders

• Jacob Wilson has put up a team-best OBP (.397) and slugging percentage (.505), while pacing the Athletics in hits (102, while batting .358).
• Including all qualifying hitters, he is second in batting average, while his on-base percentage is sixth and he is 22nd in slugging.
• Wilson brings a three-game hitting streak into this game. During his last five outings he is hitting .222 with a home run, two walks and two RBIs.
• Brent Rooker has 16 doubles, a triple, 15 home runs and 34 walks while hitting .271. He's slugging .477 with an on-base percentage of .348.
• His batting average ranks 49th among all qualified players, his on-base percentage is 53rd, and he is 34th in slugging.
• Tyler Soderstrom is batting .249 with 11 doubles, a triple, 14 home runs and 33 walks.
• Lawrence Butler is hitting .264 with 23 doubles, a triple, 11 home runs and 27 walks.

Guardians vs Athletics Head to Head

• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/20/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/19/2024: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2024: 4-3 OAK (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 12-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/29/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/28/2024: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/22/2023: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/21/2023: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)

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