Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 9:11 a.m.

In MLB action on Saturday, the Cleveland Guardians play the Athletics.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Athletics Game Info

• Cleveland Guardians (37-37) vs. Athletics (32-46)
• Date: Saturday, June 21, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and CLEG

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | OAK: (-100)
• Spread: CLE: -1.5 (+132) | OAK: +1.5 (-160)
• Total: 9.5 -- Over: (-106) | Under: (-114)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Logan Allen (Guardians) - 5-4, 4.21 ERA vs Mitch Spence (Athletics) - 2-1, 3.50 ERA

This contest's pitching matchup is set, as the Guardians will send Logan Allen (5-4) to the mound, while Mitch Spence (2-1) will take the ball for the Athletics. When Allen starts, his team is 5-7-0 against the spread this season. Allen has started three games with his team as the moneyline favorite and won each of them. The Athletics covered in each of Spence's three starts with a set spread. The Athletics are 2-1 in Spence's three starts this season that they were the moneyline underdog.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (55.6%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -118 favorite, while the Athletics are a -100 underdog at home.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +132 to cover, while the Athletics are -160 to cover.

Guardians vs Athletics Over/Under

• An over/under of 9.5 has been set for Guardians-Athletics on June 21, with the over being -106 and the under -114.

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Guardians vs Athletics Betting Trends

• The Guardians have come away with 14 wins in the 24 contests they have been listed as the favorites in this season.
• This season, the Guardians have come away with a win 11 times in 19 chances when named as a favorite of at least -118 or better on the moneyline.
• The Guardians and their opponents have hit the over in 31 of their 72 games with a total this season.
• The Guardians are 36-36-0 against the spread in their 72 games that had a posted line this season.
• The Athletics have been the underdog on the moneyline 58 total times this season. They've finished 21-37 in those games.
• The Athletics have gone 19-37 when playing as a moneyline underdog with odds of -100 or longer (33.9%).
• The Athletics have combined with their opponents to go over the total 43 times this season for a 43-32-3 record against the over/under.
• The Athletics have put together a 38-40-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez has 86 hits and an OBP of .378 to go with a slugging percentage of .528. All three of those stats rank first among Cleveland hitters this season. He has a .317 batting average, as well.
• Among qualified hitters, he ranks eighth in batting average, his on-base percentage ranks 20th, and he is 12th in slugging.
• Ramirez has recorded at least one hit in three straight games. During his last five outings he is hitting .158 with a double, a walk and an RBI.
• Steven Kwan has 15 doubles, six home runs and 25 walks. He's batting .299 and slugging .420 with an on-base percentage of .362.
• He is 16th in batting average, 30th in on-base percentage and 87th in slugging among qualified hitters.
• Kwan takes a two-game streak with at least one hit into this one. During his last five outings he is batting .250 with a double and two walks.
• Carlos Santana has collected 59 base hits, an OBP of .335 and a slugging percentage of .363 this season.
• Kyle Manzardo has 11 home runs, 31 RBI and a batting average of .212 this season.

Athletics Player Leaders

• Jacob Wilson has an on-base percentage of .397, a slugging percentage of .505, and has 102 hits, all club-bests for the Athletics (while batting .358).
• He ranks second in batting average, sixth in on-base percentage and 20th in slugging percentage among all qualifying hitters in the majors.
• Wilson hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .222 with a home run, two walks and two RBIs.
• Brent Rooker is batting .271 with 16 doubles, a triple, 15 home runs and 34 walks. He's slugging .477 with an on-base percentage of .348.
• He is currently 49th in batting average, 54th in on-base percentage and 34th in slugging percentage among all qualifying hitters.
• Tyler Soderstrom is hitting .249 with 11 doubles, a triple, 14 home runs and 33 walks.
• Lawrence Butler is hitting .264 with 23 doubles, a triple, 11 home runs and 27 walks.

Guardians vs Athletics Head to Head

• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/20/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/19/2024: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2024: 4-3 OAK (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 12-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/29/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/28/2024: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/22/2023: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/21/2023: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)

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