Giants vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 17

Odds updated as of 9:11 a.m.

On Tuesday in MLB, the San Francisco Giants are up against the Cleveland Guardians.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Giants vs Guardians Game Info

• San Francisco Giants (41-31) vs. Cleveland Guardians (35-35)
• Date: Tuesday, June 17, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and CLEG

Giants vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-164) | CLE: (+138)
• Spread: SF: -1.5 (+136) | CLE: +1.5 (-164)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Giants vs Guardians Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Giants) - 8-1, 2.55 ERA vs Slade Cecconi (Guardians) - 1-3, 4.26 ERA

This contest's pitching matchup is set, as the Giants will send Robbie Ray (8-1) to the mound, while Slade Cecconi (1-3) will answer the bell for the Guardians. Ray's team is 10-4-0 against the spread this season in his starts. Ray's team has a record of 8-2 this season when he starts and they are the favorite on the moneyline. The Guardians have a 3-2-0 record against the spread in Cecconi's starts. The Guardians are 1-2 in Cecconi's three starts this season that they were the moneyline underdog.

Giants vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (62.6%)

Giants vs Guardians Moneyline

• Looking at the moneyline for Guardians-Giants, Cleveland is the underdog at +138, and San Francisco is -164 playing at home.

Giants vs Guardians Spread

• The Giants are favored by 1.5 runs at home against the Guardians. The Giants are +136 to cover the spread, while the Guardians are -164.

Giants vs Guardians Over/Under

• The over/under for the Giants versus Guardians game on June 17 has been set at 7.5, with -100 odds on the over and -122 odds on the under.

Bet on San Francisco Giants vs. Cleveland Guardians on FanDuel today!

Giants vs Guardians Betting Trends

• The Giants have been favorites in 45 games this season and have come away with the win 27 times (60%) in those contests.
• This season San Francisco has come away with a win seven times in 11 chances when named as a favorite of at least -164 on the moneyline.
• Contests with the Giants have gone over the total set by bookmakers in 33 of 72 chances this season.
• The Giants are 34-38-0 against the spread in their 72 games with a line set by sportsbooks this season.
• The Guardians have a 19-25 record in games they were listed as the moneyline underdog (winning 43.2% of those games).
• Cleveland has gone 4-9 when playing as a moneyline underdog with odds of +138 or longer (30.8%).
• The Guardians have played in 68 games with an over/under set, and have combined with their opponents to go over the total 31 times (31-34-3).
• The Guardians have a 33-35-0 record ATS this season.

Giants Player Leaders

• Jung Hoo Lee is hitting .265 with 17 doubles, five triples, six home runs and 24 walks. He has an on-base percentage of .327 and a slugging percentage of .433.
• Among all qualified hitters in baseball, he is 60th in batting average, 79th in on-base percentage, and 70th in slugging.
• Heliot Ramos has 77 hits to go with a slugging percentage of .465, both of which rank first among San Francisco hitters this season. He's batting .286 with an on-base percentage of .359.
• Among qualified batters, his batting average ranks him 27th, his on-base percentage 34th, and his slugging percentage 45th.
• Wilmer Flores has 65 hits this season and has a slash line of .256/.324/.409.
• Mike Yastrzemski has five home runs, 24 RBI and a batting average of .248 this season.
• Yastrzemski brings a six-game hitting streak into this matchup. During his last 10 games he is batting .308 with three doubles, five walks and seven RBIs.

Guardians Player Leaders

• Jose Ramirez has an on-base percentage of .385, a slugging percentage of .543, and has 83 hits, all club-bests for the Guardians (while batting .324).
• Including all the qualifying players in the big leagues, he ranks fourth in batting average, 13th in on-base percentage and eighth in slugging percentage.
• Steven Kwan is hitting .300 with 14 doubles, six home runs and 23 walks. He's slugging .423 with an on-base percentage of .361.
• His batting average is 15th among all qualified players, his on-base percentage is 30th, and he is 83rd in slugging.
• Carlos Santana is hitting .248 with six doubles, eight home runs and 32 walks.
• Kyle Manzardo is hitting .208 with eight doubles, two triples, 11 home runs and 23 walks.

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