Giants vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 17

Odds updated as of 9:12 p.m.

The Tuesday slate in MLB includes a matchup between the San Francisco Giants and the Cleveland Guardians.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Guardians Game Info

• San Francisco Giants (41-31) vs. Cleveland Guardians (35-35)
• Date: Tuesday, June 17, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and CLEG

Giants vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-152) | CLE: (+128)
• Spread: SF: -1.5 (+142) | CLE: +1.5 (-172)
• Total: 7 -- Over: (-122) | Under: (-100)

Giants vs Guardians Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Giants) - 8-1, 2.55 ERA vs Slade Cecconi (Guardians) - 1-3, 4.26 ERA

This contest's pitching matchup is set, as the Giants will send Robbie Ray (8-1) to the mound, while Slade Cecconi (1-3) will get the nod for the Guardians. Ray's team is 10-4-0 against the spread in his starts this season. Ray's team is 8-2 this season when he starts and they are the moneyline favorite. The Guardians are 3-2-0 against the spread when Cecconi starts. The Guardians have a 1-2 record in Cecconi's three starts this season when they were the moneyline underdog.

Giants vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (62.6%)

Giants vs Guardians Moneyline

• Cleveland is the underdog, +128 on the moneyline, while San Francisco is a -152 favorite at home.

Giants vs Guardians Spread

• The Giants are hosting the Guardians and are favored by 1.5 runs (+142 to cover) on the runline. Cleveland is -172 to cover.

Giants vs Guardians Over/Under

• Giants versus Guardians on June 17 has an over/under of 7 runs, with the odds on the over -122 and the under set at -100.

Bet on San Francisco Giants vs. Cleveland Guardians on FanDuel today!

Giants vs Guardians Betting Trends

• The Giants have won in 27, or 60%, of the 45 contests they have been named as odds-on favorites in this year.
• San Francisco has a record of 11-8 when favored by -152 or more this year.
• The Giants' games have gone over the total in 33 of their 72 opportunities.
• The Giants are 34-38-0 against the spread in their 72 games with a line set by sportsbooks this season.
• The Guardians have won 19 of the 44 games they were the underdog on the moneyline this season (43.2%).
• When playing as a moneyline underdog with odds of +128 or longer, Cleveland has gone 5-9 (35.7%).
• In the 68 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 31 times (31-34-3).
• The Guardians have put together a 33-35-0 record against the spread this season (covering 48.5% of the time).

Giants Player Leaders

• Rafael Devers leads San Francisco in OBP (.401) and total hits (74) this season. He's batting .272 batting average while slugging .504.
• Among qualifying hitters in baseball, his batting average ranks 52nd, his on-base percentage ranks sixth, and he is 16th in slugging.
• Jung Hoo Lee has 17 doubles, five triples, six home runs and 24 walks. He's batting .265 and slugging .433 with an on-base percentage of .327.
• He is 61st in batting average, 80th in on-base percentage and 71st in slugging in the major leagues.
• Heliot Ramos has hit 11 homers with a team-high .465 SLG this season.
• Wilmer Flores has been key for San Francisco with 65 hits, an OBP of .324 plus a slugging percentage of .409.

Guardians Player Leaders

• Jose Ramirez has 83 hits with a .385 on-base percentage and a .543 slugging percentage, all club-highs for the Guardians. He's batting .324.
• Including all qualified players in the majors, his batting average places him fourth, his on-base percentage is 14th, and he is eighth in slugging.
• Steven Kwan is hitting .300 with 14 doubles, six home runs and 23 walks. He's slugging .423 with an on-base percentage of .361.
• Including all qualified hitters, he ranks 15th in batting average, 31st in on-base percentage and 84th in slugging percentage.
• Carlos Santana is batting .248 with six doubles, eight home runs and 32 walks.
• Kyle Manzardo is batting .208 with eight doubles, two triples, 11 home runs and 23 walks.

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