Duke vs Illinois Basketball Prediction, Odds, Picks, Best Bets for February 22

The Duke Blue Devils (23-3) hope to continue a three-game winning streak when they host the Illinois Fighting Illini (17-10) on February 22, 2025 at Madison Square Garden.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Illinois Game Info and Odds

• Game day: Saturday, February 22, 2025
• Game time: 8:00 PM ET
• TV channel: FOX
• Location: New York City, New York
• Arena: Madison Square Garden

Duke vs. Illinois Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (74.7%)

Duke is a 9.5-point favorite against Illinois on Saturday and the over/under is set at 156.5 points. Here's a few betting trends and insights before making an informed wager on the contest.

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Duke vs. Illinois: ATS Betting Stats and Trends

• Duke is 16-10-0 ATS this season.
• Illinois is 13-14-0 ATS this year.
• The Blue Devils have done a better job covering the spread when playing on the road (7-2-0) than they have in home games (9-6-0).
• Against the spread, the Fighting Illini have been better at home (8-7-0) than away (4-5-0).

Duke vs. Illinois: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 24 games this year and has walked away with the win 21 times (87.5%) in those games.
• The Blue Devils have yet to lose in 18 games when named as moneyline favorite of -365 or better.
• Illinois has compiled a 1-4 record in games it was the underdog on the moneyline (winning 20% of those games).
• The Fighting Illini have played as a moneyline underdog of +285 or longer in only one game this season, which they lost.
• Duke has an implied victory probability of 78.5% according to the moneyline set by oddsmakers for this matchup.

Duke vs. Illinois Head-to-Head Comparison

• Duke has a +524 scoring differential, topping opponents by 20.2 points per game. It is putting up 81.0 points per game to rank 33rd in college basketball and is allowing 60.8 per outing to rank fifth in college basketball.
• Duke's leading scorer, Cooper Flagg, ranks 19th in college basketball averaging 19.7 points per game.
• Illinois has a +310 scoring differential, topping opponents by 11.5 points per game. It is putting up 83.9 points per game, ninth in college basketball, and is allowing 72.4 per outing to rank 202nd in college basketball.
• Illinois' leading scorer, Kasparas Jakucionis, ranks 213th in the nation, averaging 15.6 points per game.
• The Blue Devils win the rebound battle by 9.1 boards on average. They collect 35.8 rebounds per game, which ranks 25th in college basketball, while their opponents pull down 26.7 per contest.
• Flagg is 86th in college basketball play with 7.7 rebounds per game to lead the Blue Devils.
• The Fighting Illini are first in the country at 40.9 rebounds per game. That's 10.7 more than the 30.2 their opponents average.
• Tomislav Ivisic leads the team with 8.3 rebounds per game (52nd in college basketball).
• Duke ranks second in college basketball by averaging 109.4 points per 100 possessions on offense, and defensively is seventh in college basketball, allowing 82.2 points per 100 possessions.
• The Fighting Illini average 100.9 points per 100 possessions on offense (62nd in college basketball), and allow 87.1 points per 100 possessions (46th in college basketball).

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