Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 9:11 p.m.

The MLB's Tuesday schedule includes the Los Angeles Dodgers facing the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (16-6) vs. San Francisco Giants (9-13)
• Date: Tuesday, April 21, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet LA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-180) | SF: (+152)
• Spread: LAD: -1.5 (-108) | SF: +1.5 (-111)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Yoshinobu Yamamoto (Dodgers) - 2-1, 2.10 ERA vs Landen Roupp (Giants) - 3-1, 2.38 ERA

The Dodgers will give the nod to Yoshinobu Yamamoto (2-1, 2.10 ERA), who is eyeing win No. 3 on the season, and the Giants will counter with Landen Roupp (3-1, 2.38 ERA). Yamamoto and his team have a record of 2-2-0 against the spread when he starts. When Yamamoto starts a game and his team is the favorite on the moneyline, they have a record of 3-1. The Giants have a 2-2-0 ATS record in Roupp's four starts that had a set spread. The Giants won each of Roupp's three starts this season that they were the underdog on the moneyline.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (54.8%)

Dodgers vs Giants Moneyline

• San Francisco is a +152 underdog on the moneyline, while Los Angeles is a -180 favorite on the road.

Dodgers vs Giants Spread

• The Giants are at +1.5 on the runline against the Dodgers. The Giants are -111 to cover the spread, and the Dodgers are -108.

Dodgers vs Giants Over/Under

• An over/under of 7.5 has been set for Dodgers-Giants on April 21, with the over being -102 and the under -120.

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Dodgers vs Giants Betting Trends

• The Dodgers have been favorites in 22 games this season and have come away with the win 16 times (72.7%) in those contests.
• Los Angeles has a record of 12-4 in contests when sportsbooks favor them by -180 or more on the moneyline.
• The Dodgers and their opponents have gone over the total this season in 11 of their 22 opportunities.
• The Dodgers have an against the spread record of 12-10-0 in 22 games with a line this season.
• The Giants are 6-8 in games they were listed as the moneyline underdog (winning 42.9% of those games).
• San Francisco has yet to play a game with moneyline odds of +152 or longer.
• The Giants have had an over/under set by oddsmakers 22 times, and have combined with opponents to go over the total in 10 of those games (10-9-3).
• The Giants have a 7-15-0 record against the spread this season (covering just 31.8% of the time).

Dodgers Player Leaders

• Andy Pages leads Los Angeles with an OBP of .416, plus a team-best slugging percentage of .605. He's batting .370 on the season.
• Among qualifying hitters in the majors, he ranks first in batting average, 11th in on-base percentage, and seventh in slugging.
• Pages has picked up at least one hit in two games in a row. During his last five outings he is hitting .278 with two walks and an RBI.
• Freddie Freeman is batting .296 with seven doubles, a triple, three home runs and seven walks, while slugging .519 with an on-base percentage of .360.
• He ranks 27th in batting average, 54th in on-base percentage and 28th in slugging in MLB.
• Freeman heads into this matchup looking to extend his three-game hit streak. In his last five games he is batting .421 with three doubles, a triple, three walks and an RBI.
• Shohei Ohtani has 22 hits this season and has a slash line of .272/.402/.506.
• Ohtani has recorded a hit in four games in a row. During his last five outings he is batting .333 with three doubles, two walks and an RBI.
• Max Muncy leads Los Angeles in total hits (23) this season while batting .303 with nine extra-base hits.
• Muncy enters this game on a two-game hitting streak. During his last five outings he is batting .500 with a double, four home runs, two walks and five RBIs.

Giants Player Leaders

• Luis Arraez is hitting .305 with a double, two triples and five walks. He's slugging .366 with an on-base percentage of .337.
• Including all the qualifying hitters in the big leagues, he ranks 19th in batting average, 80th in on-base percentage and 115th in slugging percentage.
• Matt Chapman's .393 slugging percentage leads his team. He has a batting average of .292 with an on-base percentage of .330.
• His batting average ranks 31st among all qualified players, his on-base percentage ranks 87th, and he is 95th in slugging.
• Jung Hoo Lee has six doubles, a home run and seven walks while hitting .244.
• Willy Adames has 10 doubles, three home runs and five walks while hitting .247.

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