Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 5:13 a.m.

The MLB's Tuesday slate includes the Los Angeles Dodgers facing the San Francisco Giants.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (16-6) vs. San Francisco Giants (9-13)
• Date: Tuesday, April 21, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet LA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-180) | SF: (+152)
• Spread: LAD: -1.5 (+100) | SF: +1.5 (-120)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Yoshinobu Yamamoto (Dodgers) - 2-1, 2.10 ERA vs Landen Roupp (Giants) - 3-1, 2.38 ERA

The probable starters are Yoshinobu Yamamoto (2-1) for the Dodgers and Landen Roupp (3-1) for the Giants. When Yamamoto starts, his team is 2-2-0 against the spread this season. When Yamamoto starts a game and his team is the favorite on the moneyline, they have a record of 3-1. The Giants have gone 2-2-0 against the spread when Roupp starts. The Giants have played as the moneyline underdog for three of Roupp's starts this season, and they won each time.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (56%)

Dodgers vs Giants Moneyline

• Looking at the moneyline for Dodgers-Giants, Los Angeles is the favorite at -180, and San Francisco is +152 playing at home.

Dodgers vs Giants Spread

• The Giants are hosting the Dodgers, and are +1.5 on the runline. The Giants are +100 to cover the spread, and the Dodgers are -120.

Dodgers vs Giants Over/Under

• The over/under for Dodgers-Giants on April 21 is 7.5. The over is +100, and the under is -122.

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Dodgers vs Giants Betting Trends

• The Dodgers have won in 16, or 72.7%, of the 22 contests they have been named as odds-on favorites in this year.
• This season Los Angeles has been victorious 12 times in 16 chances when named as a favorite of at least -180 on the moneyline.
• The Dodgers and their opponents have gone over in 11 of their 22 games with a total set by sportsbooks this season.
• The Dodgers have an against the spread mark of 12-10-0 in 22 games with a line this season.
• The Giants have won six of the 14 games they were listed as the moneyline underdog this season (42.9%).
• San Francisco has not played a game this season with moneyline odds of +152 or longer.
• In the 22 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 10 times (10-9-3).
• The Giants have put together a 7-15-0 record ATS this season (covering just 31.8% of the time).

Dodgers Player Leaders

• Andy Pages leads Los Angeles with an OBP of .416, plus a team-best slugging percentage of .605. He's batting .370 on the season.
• Among qualifying batters, he is first in batting average, his on-base percentage ranks 11th, and he is seventh in slugging.
• Pages will look for his third straight game with a hit in this contest. During his last five outings he is batting .278 with two walks and an RBI.
• Shohei Ohtani is batting .272 with four doubles, five home runs and 16 walks, while slugging .506 with an on-base percentage of .402.
• Among qualifying hitters, his batting average ranks him 55th, his on-base percentage 15th, and his slugging percentage 33rd.
• Ohtani heads into this game looking to extend his four-game hit streak. During his last five outings he is hitting .333 with three doubles, two walks and an RBI.
• Max Muncy leads Los Angeles with 23 hits. He is batting .303 this season and nine of his hits have gone for extra bases.
• Muncy brings a two-game hitting streak into this game. During his last five outings he is batting .500 with a double, four home runs, two walks and five RBIs.
• Kyle Tucker has three home runs, 13 RBI and a batting average of .256 this season.
• Tucker enters this game on a five-game hitting streak. During his last five outings he is hitting .304 with a double, two home runs, a walk and four RBIs.

Giants Player Leaders

• Luis Arraez has a double, two triples and five walks while batting .305. He's slugging .366 with an on-base percentage of .337.
• Including all the qualified hitters in MLB, his batting average puts him 19th, his on-base percentage is 80th, and he is 115th in slugging.
• Matt Chapman leads his team with a .393 slugging percentage. He has a batting average of .292 with an on-base percentage of .330.
• Including all qualified hitters, he is 31st in batting average, 87th in on-base percentage and 95th in slugging percentage.
• Jung Hoo Lee is batting .244 with six doubles, a home run and seven walks.
• Willy Adames is batting .247 with 10 doubles, three home runs and five walks.

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