Astros vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 1:13 p.m.

The Sunday slate in MLB includes a matchup between the Houston Astros and the Cleveland Guardians.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Guardians Game Info

• Houston Astros (36-42) vs. Cleveland Guardians (41-36)
• Date: Sunday, June 21, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and CleGuardians.TV

Astros vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-136) | CLE: (+116)
• Spread: HOU: -1.5 (+152) | CLE: +1.5 (-184)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Astros vs Guardians Probable Starting Pitchers

Probable Pitchers: Kai-Wei Teng (Astros) - 3-6, 4.31 ERA vs Slade Cecconi (Guardians) - 3-5, 4.60 ERA

This contest's pitching matchup is set, as the Astros will send Kai-Wei Teng (3-6) to the mound, while Slade Cecconi (3-5) will take the ball for the Guardians. Teng and his team are 3-5-0 ATS this season when he starts. Teng's team has been upset in each of the three games he's started as the moneyline favorite. The Guardians have a 6-7-0 ATS record in Cecconi's 13 starts with a set spread. The Guardians are 2-8 in Cecconi's 10 starts this season that they were the moneyline underdog.

Astros vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.9%)

Astros vs Guardians Moneyline

• The moneyline numbers for Astros vs. Guardians reveal Houston as the favorite (-136) and Cleveland as the underdog (+116) on the road.

Astros vs Guardians Spread

• The Astros are favored by 1.5 runs at home versus the Guardians. The Astros are +152 to cover the spread, while the Guardians are -184.

Astros vs Guardians Over/Under

• Astros versus Guardians on June 21 has an over/under of 8.5 runs, with the odds on the over -112 and the under set at -108.

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Astros vs Guardians Betting Trends

• The Astros have been victorious in 11, or 42.3%, of the 26 contests they have been chosen as favorites in this season.
• Houston has a record of 6-9 in contests when sportsbooks favor them by -136 or more on the moneyline.
• The Astros and their opponents have hit the over in 42 of their 78 games with a total set by oddsmakers this season.
• In 78 games with a line this season, the Astros have a mark of 36-42-0 against the spread.
• The Guardians have been the underdog on the moneyline 35 total times this season. They've gone 19-16 in those games.
• In games it has played as a moneyline underdog with odds of +116 or longer, Cleveland has an 11-9 record (winning 55% of its games).
• The Guardians have had an over/under set by bookmakers 73 times, and have combined with opponents to go over the total in 37 of those games (37-36-0).
• The Guardians have collected a 38-35-0 record ATS this season.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.424), slugging percentage (.630) and total hits (90) this season. He has a .320 batting average.
• Among qualifying hitters in MLB, he is fifth in batting average, second in on-base percentage, and first in slugging.
• Christian Walker is hitting .240 with 14 doubles, a triple, 18 home runs and 27 walks, while slugging .484 with an on-base percentage of .313.
• His batting average is 102nd among qualified players, his on-base percentage 105th, and his slugging percentage 33rd.
• Isaac Paredes has collected 60 base hits, an OBP of .342 and a slugging percentage of .413 this season.
• Paredes has logged a hit or more in five games in a row. During his last five outings he is batting .375 with two doubles, a home run, three walks and three RBIs.
• Jose Altuve has been key for Houston with 50 hits, an OBP of .313 plus a slugging percentage of .407.
• Altuve takes a two-game hitting streak into this matchup. During his last five outings he is batting .250 with a double, two home runs and five RBIs.

Guardians Player Leaders

• Brayan Rocchio has put up an on-base percentage of .348 and a slugging percentage of .393. Both lead the Guardians. He's batting .269.
• Including all the qualified players in the majors, he is 53rd in batting average, 52nd in on-base percentage and 106th in slugging percentage.
• Travis Bazzana is hitting .274 with 11 doubles, a triple, seven home runs and 24 walks. He's slugging .476 with an on-base percentage of .369.
• Steven Kwan is batting .207 with eight doubles, a home run and 37 walks.
• Kyle Manzardo is batting .238 with seven doubles, a triple, nine home runs and 24 walks.

Astros vs Guardians Head to Head

• 6/20/2026: 8-1 CLE (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/19/2026: 9-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/22/2026: 2-0 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/21/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/20/2026: 9-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/9/2025: 4-2 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/8/2025: 10-6 CLE (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/7/2025: 7-5 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/7/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)

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