Diamondbacks vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 1:11 a.m.

The Arizona Diamondbacks versus the San Diego Padres is on the MLB schedule for Saturday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Padres Game Info

• Arizona Diamondbacks (14-11) vs. San Diego Padres (17-8)
• Date: Saturday, April 25, 2026
• Time: 6:05 p.m. ET
• Venue: Estadio Alfredo Harp Helu -- Mexico City, Mexico
• Coverage: Dbacks.TV and Padres.TV

Diamondbacks vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-112) | SD: (-104)
• Spread: ARI: +1.5 (-152) | SD: -1.5 (+126)
• Total: 15.5 -- Over: (-110) | Under: (-110)

Diamondbacks vs Padres Probable Starting Pitchers

Probable Pitchers: Zac Gallen (Diamondbacks) - 1-1, 3.51 ERA vs German Marquez (Padres) - 2-1, 3.86 ERA

The probable pitchers are Zac Gallen (1-1) for the Diamondbacks and German Marquez (2-1) for the Padres. When Gallen starts, his team is 4-1-0 against the spread this season. Gallen's team won his only start as a favorite this season. The Padres have a 3-1-0 record against the spread in Marquez's starts. The Padres were named the moneyline underdog for two Marquez starts this season -- they split the games.

Diamondbacks vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (55.4%)

Diamondbacks vs Padres Moneyline

• Arizona is a -112 favorite on the moneyline, while San Diego is a -104 underdog on the road.

Diamondbacks vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Padres are +126 to cover, while the Diamondbacks are -152 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Padres Over/Under

• A combined run total of 15.5 has been set for Diamondbacks-Padres on April 25, with the over at -110 and the under at -110.

Bet on Arizona Diamondbacks vs. San Diego Padres on FanDuel today!

Diamondbacks vs Padres Betting Trends

• The Diamondbacks have won in six of the eight contests they have been named as odds-on favorites in this year.
• This season Arizona has come away with a win six times in eight chances when named as a favorite of at least -112 on the moneyline.
• Contests with the Diamondbacks have gone over the total set by oddsmakers in 15 of 25 chances this season.
• The Diamondbacks are 18-7-0 against the spread in their 25 games that had a posted line this season.
• The Padres have compiled a 5-5 record in games they were the underdog on the moneyline (winning 50% of those games).
• San Diego has a record of 5-5 when playing as a moneyline underdog with odds of -104 or longer (50%).
• In the 25 games oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total 10 times (10-14-1).
• The Padres have put together a 16-9-0 record ATS this season (covering 64% of the time).

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona with 24 hits and an OBP of .396 this season. He has a .296 batting average and a slugging percentage of .580.
• He is 22nd in batting average, 16th in on-base percentage, and 10th in slugging among all qualified hitters in baseball.
• Ildemaro Vargas leads Arizona in slugging percentage (.671) thanks to 11 extra-base hits. He's batting .357 with an on-base percentage of .375.
• Vargas has picked up a hit in 18 games in a row. In his last 10 outings he is batting .310 with three doubles, four home runs and 11 RBIs.
• Geraldo Perdomo is batting .259 with a .407 slugging percentage and six RBI this year.
• Perdomo brings a seven-game hitting streak into this game. In his last 10 outings he is batting .351 with a double, three triples, five walks and two RBIs.
• Ketel Marte is batting .240 with a .298 OBP and nine RBI for Arizona this season.
• Marte enters this matchup on a four-game hitting streak. During his last five outings he is batting .300 with a double and two walks.

Padres Player Leaders

• Xander Bogaerts has an on-base percentage of .366 and a slugging percentage of .444. Both lead the Padres. He's batting .289.
• Including all the qualifying hitters in the majors, his batting average places him 31st, his on-base percentage ranks 33rd, and he is 58th in slugging.
• Bogaerts hopes to build on a five-game hitting streak in this matchup. In his last five games he is hitting .412 with a home run, four walks and three RBIs.
• Ramon Laureano's 24 hits pace his team. He has a batting average of .264 while slugging .484 with an on-base percentage of .320.
• Including all qualified hitters, his batting average puts him 62nd, his on-base percentage ranks 113th, and he is 39th in slugging.
• Jackson Merrill is batting .211 with six doubles, three home runs and eight walks.
• Manny Machado has two doubles, two home runs and 17 walks while batting .195.

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