Diamondbacks vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 6:12 p.m.

On Saturday in MLB, the Arizona Diamondbacks are up against the San Diego Padres.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Padres Game Info

• Arizona Diamondbacks (14-11) vs. San Diego Padres (17-8)
• Date: Saturday, April 25, 2026
• Time: 6:05 p.m. ET
• Venue: Estadio Alfredo Harp Helu -- Mexico City, Mexico
• Coverage: Dbacks.TV and Padres.TV

Diamondbacks vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-116) | SD: (-102)
• Spread: ARI: +1.5 (-156) | SD: -1.5 (+130)
• Total: 16 -- Over: (-105) | Under: (-115)

Diamondbacks vs Padres Probable Starting Pitchers

Probable Pitchers: Zac Gallen (Diamondbacks) - 1-1, 3.51 ERA vs German Marquez (Padres) - 2-1, 3.86 ERA

The Diamondbacks will give the nod to Zac Gallen (1-1, 3.51 ERA), who is eyeing win No. 2 on the season, and the Padres will counter with German Marquez (2-1, 3.86 ERA). When Gallen starts, his team is 4-1-0 against the spread this season. Gallen's team won his only start as a favorite this season. The Padres have a 3-1-0 ATS record in Marquez's four starts that had a set spread. The Padres were the underdog on the moneyline for two Marquez starts this season -- they split the games.

Diamondbacks vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (52.8%)

Diamondbacks vs Padres Moneyline

• Looking at the moneyline for Padres-Diamondbacks, San Diego is the underdog at -102, and Arizona is -116 playing at home.

Diamondbacks vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Padres are +130 to cover, while the Diamondbacks are -156 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Padres Over/Under

• The Diamondbacks-Padres game on April 25 has been given an over/under of 16 runs. The over is set at -105 and the under at -115.

Bet on Arizona Diamondbacks vs. San Diego Padres on FanDuel today!

Diamondbacks vs Padres Betting Trends

• The Diamondbacks have been favorites in eight games this season and have come away with the win six times (75%) in those contests.
• Arizona has a record of 4-2 in contests when bookmakers favor them by -116 or more on the moneyline.
• The Diamondbacks and their opponents have hit the over in 15 of their 25 games with a total set by oddsmakers this season.
• The Diamondbacks have an against the spread record of 18-7-0 in 25 games with a line this season.
• The Padres have won five of the 10 games they were listed as the moneyline underdog this season (50%).
• In games it has played as a moneyline underdog with odds of -102 or longer, San Diego has a 5-5 record (winning 50% of its games).
• In the 25 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 10 times (10-14-1).
• The Padres have covered 64% of their games this season, going 16-9-0 against the spread.

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona in OBP (.396) and total hits (24) this season. He's batting .296 batting average while slugging .580.
• Among all qualified batters in baseball, he is 22nd in batting average, 17th in on-base percentage, and ninth in slugging.
• Ildemaro Vargas leads Arizona in slugging percentage (.671) thanks to 11 extra-base hits. He's batting .357 with an on-base percentage of .375.
• Vargas takes an 18-game streak with at least one hit into this matchup. In his last 10 outings he is batting .310 with three doubles, four home runs and 11 RBIs.
• Geraldo Perdomo has 21 hits this season and has a slash line of .259/.361/.407.
• Perdomo brings a seven-game hitting streak into this game. During his last 10 outings he is hitting .351 with a double, three triples, five walks and two RBIs.
• Ketel Marte is batting .240 with a .298 OBP and nine RBI for Arizona this season.
• Marte heads into this game on a four-game hitting streak. During his last five outings he is hitting .300 with a double and two walks.

Padres Player Leaders

• Xander Bogaerts has racked up a team-best OBP (.366) and slugging percentage (.444). He's batting .289.
• Including all the qualified players in MLB, he ranks 30th in batting average, 35th in on-base percentage and 59th in slugging percentage.
• Bogaerts enters this matchup on a five-game hitting streak. During his last five outings he is hitting .412 with a home run, four walks and three RBIs.
• Ramon Laureano's 24 hits lead his team. He has a batting average of .264 while slugging .484 with an on-base percentage of .320.
• Including all qualified players, he ranks 65th in batting average, 112th in on-base percentage and 36th in slugging percentage.
• Jackson Merrill is batting .211 with six doubles, three home runs and eight walks.
• Manny Machado is hitting .195 with two doubles, two home runs and 17 walks.

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