Diamondbacks vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 20

Odds updated as of 3:11 p.m.

On Wednesday in MLB, the Arizona Diamondbacks are up against the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Diamondbacks vs Guardians Game Info

• Arizona Diamondbacks (61-66) vs. Cleveland Guardians (64-61)
• Date: Wednesday, August 20, 2025
• Time: 3:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and CLEG

Diamondbacks vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-118) | CLE: (-100)
• Spread: ARI: -1.5 (+168) | CLE: +1.5 (-205)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Diamondbacks vs Guardians Probable Starting Pitchers

Probable Pitchers: Brandon Pfaadt (Diamondbacks) - 12-8, 5.01 ERA vs Parker Messick (Guardians) - 0-0, 0.00 ERA

The Diamondbacks will give the nod to Brandon Pfaadt (12-8, 5.01 ERA), who is eyeing win No. 13 on the season, and the Guardians will turn to Parker Messick. When Pfaadt starts, his team is 14-11-0 against the spread this season. Pfaadt's team has won 50% of his starts when they are favored on the moneyline (7-7). Messick's team was never the underdog on the moneyline a season ago in games he pitched.

Diamondbacks vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (67.6%)

Diamondbacks vs Guardians Moneyline

• Cleveland is the underdog, -100 on the moneyline, while Arizona is a -118 favorite at home.

Diamondbacks vs Guardians Spread

• The Diamondbacks are hosting the Guardians and are favored by 1.5 runs (+168 to cover) on the runline. Cleveland is -205 to cover.

Diamondbacks vs Guardians Over/Under

• A total of 8.5 runs has been set for the Diamondbacks-Guardians game on Aug. 20, with the over available at -118 and the under at -104.

Bet on Arizona Diamondbacks vs. Cleveland Guardians on FanDuel today!

Diamondbacks vs Guardians Betting Trends

• The Diamondbacks have been favorites in 75 games this season and have come away with the win 38 times (50.7%) in those contests.
• This season Arizona has been victorious 31 times in 62 chances when named as a favorite of at least -118 on the moneyline.
• The Diamondbacks and their opponents have gone over the total this season in 61 of their 123 opportunities.
• In 123 games with a line this season, the Diamondbacks have a mark of 57-66-0 against the spread.
• The Guardians have won 29 of the 67 games they were the moneyline underdog this season (43.3%).
• Cleveland is 23-29 (winning 44.2% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Guardians have played in 122 games with an over/under set, and have combined with their opponents to go over the total 56 times (56-62-4).
• The Guardians have put together a 64-58-0 record against the spread this season (covering 52.5% of the time).

Diamondbacks Player Leaders

• Geraldo Perdomo has an OPS of .833, fueled by an OBP of .390 and a team-best slugging percentage of .443 this season. He has a .289 batting average.
• Among all qualifying hitters in MLB, his batting average ranks 21st, his on-base percentage ranks seventh, and he is 71st in slugging.
• Perdomo has recorded a base hit in four games in a row. During his last five outings he is hitting .316 with a triple, four walks and two RBIs.
• Corbin Carroll leads Arizona in total hits (112) this season while batting .253 with 65 extra-base hits. He's slugging .559 with an on-base percentage of .329.
• Among qualified hitters, his batting average places him 94th, his on-base percentage 77th, and his slugging percentage fifth.
• Carroll has picked up at least one hit in seven straight games. During his last 10 outings he is batting .310 with two doubles, two triples, two home runs, five walks and six RBIs.
• Ketel Marte leads Arizona with an OBP of .393 this season while batting .293 with 54 walks and 69 runs scored.
• Lourdes Gurriel Jr. has 16 home runs, 69 RBI and a batting average of .247 this season.
• Gurriel has hit safely in six games in a row. During his last 10 games he is batting .222 with a double, two home runs, three walks and 10 RBIs.

Guardians Player Leaders

• Jose Ramirez has a team-high OBP (.365) and slugging percentage (.518), and paces the Guardians in hits (134, while batting .291).
• He ranks 17th in batting average, 23rd in on-base percentage and 13th in slugging percentage among all qualified batters in the majors.
• Steven Kwan has 22 doubles, a triple, 10 home runs and 43 walks while batting .278. He's slugging .392 with an on-base percentage of .338.
• His batting average is 32nd among all qualified players, his on-base percentage ranks 60th, and he is 118th in slugging.
• Carlos Santana has nine doubles, 11 home runs and 52 walks while batting .226.
• Kyle Manzardo has 14 doubles, two triples, 21 home runs and 40 walks while hitting .235.

Diamondbacks vs Guardians Head to Head

• 8/19/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/18/2025: 3-1 CLE (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/7/2024: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/7/2024: 7-3 ARI (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/5/2024: 7-6 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/18/2023: 12-3 CLE (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/17/2023: 6-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/16/2023: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +160)

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