Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 25

Odds updated as of 7:11 p.m.

The Friday slate in MLB includes a matchup between the Chicago Cubs and the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cubs vs White Sox Game Info

• Chicago Cubs (60-42) vs. Chicago White Sox (37-66)
• Date: Friday, July 25, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MARQ

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-186) | CHW: (+156)
• Spread: CHC: -1.5 (-110) | CHW: +1.5 (-110)
• Total: 8 -- Over: (-115) | Under: (-105)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 7-3, 2.40 ERA vs Adrian Houser (White Sox) - 5-2, 1.89 ERA

The Cubs will give the ball to Shota Imanaga (7-3, 2.40 ERA), who is eyeing win No. 8 on the season, and the White Sox will counter with Adrian Houser (5-2, 1.89 ERA). When Imanaga starts, his team is 7-6-0 against the spread this season. Imanaga's team is 6-2 this season when he starts and they are the moneyline favorite. The White Sox have a 7-2-0 ATS record in Houser's nine starts with a set spread. The White Sox are 5-3 in Houser's eight starts this season that they were the moneyline underdog.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (57.9%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -186 favorite, while the White Sox are a +156 underdog at home.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -110 to cover, while the White Sox are -110 to cover.

Cubs vs White Sox Over/Under

• The over/under for the Cubs versus White Sox game on July 25 has been set at 8, with -115 odds on the over and -105 odds on the under.

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Cubs vs White Sox Betting Trends

• The Cubs have been favorites in 65 games this season and have come away with the win 45 times (69.2%) in those contests.
• This season, the Cubs have come away with a win 12 times in 13 chances when named as a favorite of at least -186 or shorter on the moneyline.
• The Cubs and their opponents have hit the over in 50 of their 99 games with a total this season.
• In 99 games with a line this season, the Cubs have a mark of 49-50-0 against the spread.
• The White Sox have won 34 of the 96 games they were listed as the moneyline underdog this season (35.4%).
• The White Sox have gone 11-35 when playing as a moneyline underdog with odds of +156 or longer (23.9%).
• The White Sox have combined with their opponents to hit the over on the total 44 times this season for a 44-50-5 record against the over/under.
• The White Sox have gone 55-44-0 ATS this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .383 this season while batting .275 with 65 walks and 71 runs scored. He has a slugging percentage of .493.
• Among all qualified hitters in MLB, he ranks 48th in batting average, eighth in on-base percentage, and 25th in slugging.
• Pete Crow-Armstrong leads Chicago in total hits (106) this season while batting .270 with 56 extra-base hits. He's slugging .560 with an on-base percentage of .305.
• Among all qualifying players, he is 60th in batting average, 125th in on-base percentage and eighth in slugging percentage.
• Crow-Armstrong enters this matchup looking to extend his six-game hit streak. In his last 10 outings he is hitting .275 with five doubles, four home runs, a walk and seven RBIs.
• Seiya Suzuki is batting .256 with a .532 slugging percentage and 81 RBI this year.
• Nico Hoerner leads Chicago with a slugging percentage of .374, fueled by 24 extra-base hits.
• Hoerner has safely hit in two straight games. In his last five games he is batting .350 with an RBI.

White Sox Player Leaders

• Miguel Vargas has a slugging percentage of .402, a team-high for the White Sox. He's batting .223 with an on-base percentage of .306.
• He is 145th in batting average, 123rd in on-base percentage and 102nd in slugging percentage among all qualified hitters in the majors.
• Andrew Benintendi is batting .236 with 12 doubles, two triples, 11 home runs and 27 walks. He's slugging .425 with an on-base percentage of .307.
• Luis Robert has nine doubles, 10 home runs and 35 walks while hitting .206.
• Chase Meidroth's .330 on-base percentage leads his team.

Cubs vs White Sox Head to Head

• 5/18/2025: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/17/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 10, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/16/2025: 13-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/10/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/9/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/4/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -300, Underdog Moneyline: +245)
• 8/16/2023: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/15/2023: 5-3 CHW (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 7/26/2023: 10-7 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)

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