Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 18

Odds updated as of 2:11 p.m.

The MLB's Sunday slate includes the Chicago Cubs facing the Chicago White Sox.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs White Sox Game Info

• Chicago Cubs (27-19) vs. Chicago White Sox (14-32)
• Date: Sunday, May 18, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and CHSN

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-260) | CHW: (+215)
• Spread: CHC: -1.5 (-118) | CHW: +1.5 (-102)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 3-0, 2.48 ERA vs Jonathan Cannon (White Sox) - 2-4, 3.60 ERA

This contest's pitching matchup is set, as the Cubs will send Colin Rea (3-0) to the mound, while Jonathan Cannon (2-4) will get the nod for the White Sox. Rea's team is 4-1-0 against the spread this season in his starts. Rea's team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have gone 3-4-0 ATS in Cannon's seven starts that had a set spread. The White Sox have a 1-6 record in Cannon's seven starts this season when they were the moneyline underdog.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (69.3%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -260 favorite, while the White Sox are a +215 underdog on the road.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -118 to cover, while the White Sox are -102 to cover.

Cubs vs White Sox Over/Under

• Cubs versus White Sox on May 18 has an over/under of 7.5 runs, with the odds on the over -105 and the under set at -115.

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Cubs vs White Sox Betting Trends

• The Cubs have been chosen as favorites in 24 games this year and have walked away with the win 17 times (70.8%) in those games.
• The Cubs have been listed as a favorite of -260 or more on two occasions this season and won both games.
• The Cubs and their opponents have hit the over in 27 of their 44 games with a total this season.
• The Cubs are 23-21-0 against the spread in their 44 games with a line set by sportsbooks this season.
• The White Sox have put together a 13-31 record in games they were listed as the moneyline underdog (winning 29.5% of those games).
• When playing as a moneyline underdog with odds of +215 or longer, the White Sox have a record of 1-3 (25%).
• The White Sox have played in 45 games with a set over/under, and have combined with their opponents to go over the total 20 times (20-22-3).
• The White Sox have put together a 23-22-0 record ATS this season (covering 51.1% of the time).

Cubs Player Leaders

• Kyle Tucker has 47 hits this season and a team-best OBP of .377. He has a .264 batting average and a slugging percentage of .528.
• Among all qualifying batters in MLB, his batting average ranks 61st, his on-base percentage ranks 27th, and he is 16th in slugging.
• Pete Crow-Armstrong has 51 hits to go with a slugging percentage of .570, both of which rank first among Chicago hitters this season. He's batting .285 with an on-base percentage of .321.
• He ranks 38th in batting average, 96th in on-base percentage and ninth in slugging in the majors.
• Crow-Armstrong enters this game looking to extend his four-game hit streak. During his last five outings he is hitting .450 with a triple, two home runs, a walk and 10 RBIs.
• Dansby Swanson has collected 44 base hits, an OBP of .316 and a slugging percentage of .477 this season.
• Swanson takes a three-game hitting streak into this game. In his last five games he is batting .353 with two home runs, four walks and four RBIs.
• Seiya Suzuki has been key for Chicago with 42 hits, an OBP of .298 plus a slugging percentage of .517.
• Suzuki has hit safely in three games in a row. During his last five outings he is hitting .250 with three doubles, two home runs, a walk and five RBIs.

White Sox Player Leaders

• Miguel Vargas has a team-high OBP (.318), while leading the White Sox in hits (37). He's batting .237 and slugging.
• Including all qualified hitters, he is 113th in batting average, while his on-base percentage ranks 100th and he is 96th in slugging.
• Luis Robert has three doubles, five home runs and 21 walks while hitting .176. He's slugging .297 with an on-base percentage of .276.
• Including all qualifying hitters, his batting average places him 161st, his on-base percentage is 139th, and he is 157th in slugging.
• Lenyn Sosa has put up a team-high .366 slugging percentage.
• Andrew Vaughn has eight doubles, five home runs and seven walks while hitting .186.

Cubs vs White Sox Head to Head

• 5/17/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 10, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/16/2025: 13-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/10/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/9/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/4/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -300, Underdog Moneyline: +245)
• 8/16/2023: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/15/2023: 5-3 CHW (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 7/26/2023: 10-7 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/25/2023: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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