Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 17

Odds updated as of 2:13 p.m.

The Chicago Cubs will take on the Chicago White Sox in MLB action on Saturday.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs White Sox Game Info

• Chicago Cubs (26-19) vs. Chicago White Sox (14-31)
• Date: Saturday, May 17, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and CHSN

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-310) | CHW: (+250)
• Spread: CHC: -1.5 (-156) | CHW: +1.5 (+130)
• Total: 10 -- Over: (-105) | Under: (-115)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 3-2, 2.78 ERA vs Sean Burke (White Sox) - 2-4, 4.15 ERA

This contest's pitching matchup is set, as the Cubs will send Matthew Boyd (3-2) to the mound, while Sean Burke (2-4) will get the nod for the White Sox. Boyd's team is 2-6-0 against the spread in his starts this season. Boyd's team has a record of 3-1 this season when he starts and they are the favorite on the moneyline. The White Sox have a 6-2-0 record against the spread in Burke's starts. The White Sox have a 4-4 record in Burke's eight starts this season when they were the moneyline underdog.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (70.7%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -310 favorite, while the White Sox are a +250 underdog on the road.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -156 to cover, while the White Sox are +130 to cover.

Cubs vs White Sox Over/Under

• The over/under for the Cubs versus White Sox contest on May 17 has been set at 10, with -105 odds on the over and -115 odds on the under.

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Cubs vs White Sox Betting Trends

• The Cubs have been victorious in 16, or 69.6%, of the 23 contests they have been chosen as favorites in this season.
• The Cubs have yet to enter a game this year with shorter moneyline odds than -310.
• The Cubs and their opponents have hit the over in 27 of their 43 games with a total this season.
• The Cubs have posted a record of 22-21-0 against the spread this season.
• The White Sox have been the underdog on the moneyline 43 total times this season. They've gone 13-30 in those games.
• The White Sox have played as a moneyline underdog of +250 or longer in just one game this season, which they lost.
• The White Sox have combined with their opponents to go over the total 20 times this season for a 20-22-2 record against the over/under.
• The White Sox have a 23-21-0 record against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.372) this season, fueled by 47 hits. He has a .267 batting average and a slugging percentage of .534.
• Among qualifying hitters, he ranks 60th in batting average, his on-base percentage ranks 32nd, and he is 15th in slugging.
• Tucker hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .200 with a double, two triples, a walk and an RBI.
• Pete Crow-Armstrong leads Chicago with 49 hits and a team-best slugging percentage of .563. He's batting .282 with an on-base percentage of .319.
• He is 41st in batting average, 97th in on-base percentage and ninth in slugging among qualifying hitters.
• Crow-Armstrong takes a three-game streak with at least one hit into this one. During his last five outings he is hitting .421 with three home runs, a walk and nine RBIs.
• Seiya Suzuki has collected 41 base hits, an OBP of .301 and a slugging percentage of .521 this season.
• Suzuki takes a two-game hitting streak into this game. During his last five outings he is batting .211 with two doubles, two home runs, a walk and five RBIs.
• Carson Kelly has eight home runs, 23 RBI and a batting average of .299 this season.

White Sox Player Leaders

• Miguel Vargas has totaled 37 hits with a .326 on-base percentage, leading the White Sox in both categories. He's batting .242 and slugging .405.
• Including all the qualifying hitters in the big leagues, his batting average puts him 103rd, his on-base percentage ranks 88th, and he is 87th in slugging.
• Luis Robert is batting .181 with three doubles, five home runs and 21 walks. He's slugging .306 with an on-base percentage of .283.
• Including all qualified players, his batting average puts him 160th, his on-base percentage is 132nd, and he is 155th in slugging.
• Lenyn Sosa has a .373 slugging percentage, which leads the White Sox.
• Andrew Vaughn has eight doubles, five home runs and seven walks while hitting .185.

Cubs vs White Sox Head to Head

• 5/16/2025: 13-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/10/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/9/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/4/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -300, Underdog Moneyline: +245)
• 8/16/2023: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/15/2023: 5-3 CHW (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 7/26/2023: 10-7 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/25/2023: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/29/2022: 5-4 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)

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