Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 2:11 a.m.

On Friday in MLB, the Chicago Cubs are playing the Chicago White Sox.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs White Sox Game Info

• Chicago Cubs (25-19) vs. Chicago White Sox (14-30)
• Date: Friday, May 16, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and CHSN

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-225) | CHW: (+188)
• Spread: CHC: -1.5 (-111) | CHW: +1.5 (-108)
• Total: 11.5 -- Over: (-110) | Under: (-110)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 1-0, 6.75 ERA vs Shane Smith (White Sox) - 1-2, 2.08 ERA

This contest's pitching matchup is set, as the Cubs will send Cade Horton (1-0) to the mound, while Shane Smith (1-2) will get the nod for the White Sox. Horton did not pitch as the moneyline favorite in any games last season. The White Sox have a 3-5-0 record against the spread in Smith's starts. The White Sox are 1-6 in Smith's seven starts this season that they were the moneyline underdog.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.9%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -225 favorite, while the White Sox are a +188 underdog on the road.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -111 to cover, while the White Sox are -108 to cover.

Cubs vs White Sox Over/Under

• The over/under for Cubs-White Sox on May 16 is 11.5. The over is -110, and the under is -110.

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Cubs vs White Sox Betting Trends

• The Cubs have been chosen as favorites in 22 games this year and have walked away with the win 15 times (68.2%) in those games.
• The Cubs have been listed as a favorite of -225 or more on two occasions this season and won both games.
• The Cubs and their opponents have hit the over in 26 of their 42 games with a total this season.
• The Cubs have posted a record of 21-21-0 against the spread this season.
• The White Sox have gone 13-29 in games they were the underdog on the moneyline (winning 31% of those games).
• The White Sox have gone 2-14 when playing as a moneyline underdog with odds of +188 or longer (12.5%).
• The White Sox have combined with their opponents to go over the total 19 times this season for a 19-22-2 record against the over/under.
• The White Sox have a 23-20-0 record against the spread this season (covering 53.5% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago OPS (.898) this season. He has a .263 batting average, an on-base percentage of .371, and a slugging percentage of .526.
• He is 66th in batting average, 34th in on-base percentage, and 18th in slugging among qualified hitters in baseball.
• Pete Crow-Armstrong leads Chicago with 45 hits and a team-best slugging percentage of .538. He's batting .266 with an on-base percentage of .306.
• Among qualifying hitters, he is 62nd in batting average, 113th in on-base percentage and 16th in slugging percentage.
• Crow-Armstrong takes a two-game streak with at least one hit into this one. During his last five outings he is batting .263 with two home runs, a walk and three RBIs.
• Seiya Suzuki is batting .239 with a .509 slugging percentage and 35 RBI this year.
• Dansby Swanson has been key for Chicago with 41 hits, an OBP of .306 plus a slugging percentage of .461.

White Sox Player Leaders

• Miguel Vargas a has .310 on-base percentage to lead the White Sox. He's batting .221 while slugging .342.
• Including all qualifying hitters, he ranks 130th in batting average, while his on-base percentage ranks 105th and he is 135th in slugging.
• Luis Robert is batting .186 with three doubles, five home runs and 21 walks. He's slugging .314 with an on-base percentage of .290.
• Including all qualifying players, he is 158th in batting average, 131st in on-base percentage and 153rd in slugging percentage.
• Lenyn Sosa has a slugging percentage of .373 and has 40 hits, both team-best figures for the White Sox.
• Andrew Vaughn is batting .189 with eight doubles, five home runs and seven walks.

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