Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 2:11 p.m.

The Friday slate in MLB includes a matchup between the Chicago Cubs and the Chicago White Sox.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs White Sox Game Info

• Chicago Cubs (25-19) vs. Chicago White Sox (14-30)
• Date: Friday, May 16, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and CHSN

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-235) | CHW: (+194)
• Spread: CHC: -1.5 (-113) | CHW: +1.5 (-106)
• Total: 11.5 -- Over: (-112) | Under: (-108)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 1-0, 6.75 ERA vs Shane Smith (White Sox) - 1-2, 2.08 ERA

The Cubs will give the ball to Cade Horton (1-0, 6.75 ERA), who is eyeing win No. 2 on the season, and the White Sox will counter with Shane Smith (1-2, 2.08 ERA). Horton did not appear in a game when his team was the moneyline favorite last season. When Smith starts, the White Sox are 3-5-0 against the spread. The White Sox have a 1-6 record in Smith's seven starts this season when they were the moneyline underdog.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.8%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -235 favorite, while the White Sox are a +194 underdog on the road.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -113 to cover, while the White Sox are -106 to cover.

Cubs vs White Sox Over/Under

• The Cubs-White Sox contest on May 16 has been given an over/under of 11.5 runs. The over is set at -112 and the under at -108.

Bet on Chicago Cubs vs. Chicago White Sox on FanDuel today!

Cubs vs White Sox Betting Trends

• The Cubs have won in 15, or 68.2%, of the 22 contests they have been named as odds-on favorites in this year.
• The Cubs have been listed as a favorite of -235 or more on two occasions this season and won both games.
• The Cubs and their opponents have hit the over in 26 of their 42 games with a total this season.
• In 42 games with a line this season, the Cubs have a mark of 21-21-0 against the spread.
• The White Sox are 13-29 in games they were the underdog on the moneyline (winning 31% of those games).
• The White Sox have a record of 2-11 when playing as a moneyline underdog with odds of +194 or longer (15.4%).
• The White Sox have played in 43 games with a set over/under, and have combined with their opponents to go over the total 19 times (19-22-2).
• The White Sox have gone 23-20-0 against the spread this season.

Cubs Player Leaders

• Kyle Tucker has an OPS of .898, fueled by an OBP of .371 to go with a slugging percentage of .526. He has a .263 batting average, as well.
• Among all qualified batters in the majors, he ranks 67th in batting average, 34th in on-base percentage, and 18th in slugging.
• Pete Crow-Armstrong leads Chicago in slugging percentage (.538) and total hits (45) this season. He's batting .266 with an on-base percentage of .306.
• He is 63rd in batting average, 113th in on-base percentage and 16th in slugging among qualifying hitters.
• Crow-Armstrong has picked up a hit in two games in a row. During his last five outings he is batting .263 with two home runs, a walk and three RBIs.
• Seiya Suzuki has 39 hits this season and has a slash line of .239/.298/.509.
• Carson Kelly has eight home runs, 23 RBI and a batting average of .289 this season.

White Sox Player Leaders

• Miguel Vargas a has .310 on-base percentage to lead the White Sox. He's batting .221 while slugging .342.
• He ranks 130th in batting average, 106th in on-base percentage and 135th in slugging percentage among all qualified batters in the majors.
• Luis Robert is batting .186 with three doubles, five home runs and 21 walks. He's slugging .314 with an on-base percentage of .290.
• His batting average is 158th among all qualified players, his on-base percentage ranks 130th, and he is 154th in slugging.
• Lenyn Sosa has accumulated a team-best slugging percentage (.373) while leading the White Sox in hits (40).
• Andrew Vaughn has eight doubles, five home runs and seven walks while batting .189.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!