Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 11:11 p.m.

The Chicago Cubs will face the San Diego Padres in MLB action on Wednesday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Padres Game Info

• Chicago Cubs (17-12) vs. San Diego Padres (19-9)
• Date: Wednesday, April 29, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and MARQ

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-118) | SD: (+100)
• Spread: CHC: -1.5 (+132) | SD: +1.5 (-160)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 1-1, 4.55 ERA vs Matt Waldron (Padres) - 0-1, 12.46 ERA

The probable pitchers are Jameson Taillon (1-1) for the Cubs and Matt Waldron (0-1) for the Padres. Taillon's team is 2-3-0 against the spread in his starts this season. When Taillon starts a game and his team is the favorite on the moneyline, they have a record of 2-1. Waldron has started two games with set spreads, and the Padres went 1-1-0. The Padres were named the moneyline underdog for one Waldron start this season -- they lost.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (53.5%)

Cubs vs Padres Moneyline

• Looking at the moneyline for Padres-Cubs, San Diego is the underdog at +100, and Chicago is -118 playing on the road.

Cubs vs Padres Spread

• The Padres are hosting the Cubs, and are +1.5 on the runline. The Padres are +132 to cover the spread, and the Cubs are -160.

Cubs vs Padres Over/Under

• Cubs versus Padres, on April 29, has an over/under of 8.5, with the over being -108 and the under -112.

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Cubs vs Padres Betting Trends

• The Cubs have come away with 11 wins in the 18 contests they have been listed as the favorites in this season.
• Chicago has a record of 9-7 when favored by -118 or more this year.
• The Cubs and their opponents have hit the over in 18 of their 29 games with a total set by oddsmakers this season.
• The Cubs have posted a record of 14-15-0 against the spread this season.
• The Padres have won 54.5% of the games this season they were the moneyline underdog (6-5).
• San Diego has gone 5-5 when playing as a moneyline underdog with odds of +100 or longer (50%).
• The Padres have played in 28 games with a set over/under, and have combined with their opponents to go over the total 12 times (12-15-1).
• The Padres have an 18-10-0 record ATS this season (covering 64.3% of the time).

Cubs Player Leaders

• Nico Hoerner has an OPS of .833, fueled by an OBP of .375 to go with a slugging percentage of .458. He has a .297 batting average, as well.
• Among qualified hitters in baseball, he ranks 27th in batting average, 28th in on-base percentage, and 51st in slugging.
• Dansby Swanson is hitting .206 with a double, a triple, six home runs and 20 walks. He's slugging .423 with an on-base percentage of .339.
• Among qualifying hitters, his batting average places him 150th, his on-base percentage 76th, and his slugging percentage 74th.
• Moises Ballesteros has 24 hits this season and has a slash line of .387/.435/.710.
• Ballesteros heads into this game with five games in a row with at least one hit. In his last five games he is hitting .412 with four doubles, two home runs, a walk and five RBIs.
• Ian Happ leads Chicago with 25 hits, batting .236 this season with 11 extra-base hits.

Padres Player Leaders

• Xander Bogaerts has racked up a team-high OBP (.360) and slugging percentage (.422). He's batting .284.
• Including all the qualified players in MLB, his batting average is 39th, his on-base percentage ranks 42nd, and he is 76th in slugging.
• Manny Machado is batting .232 with four doubles, four home runs and 17 walks. He's slugging .400 with an on-base percentage of .342.
• Including all qualifying hitters, his batting average places him 117th, his on-base percentage ranks 74th, and he is 93rd in slugging.
• Ramon Laureano has four doubles, two triples, four home runs and 10 walks while hitting .255.
• Jackson Merrill has six doubles, three home runs and nine walks while batting .213.

Cubs vs Padres Head to Head

• 4/27/2026: 9-7 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/2/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/1/2025: 3-0 SD (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/30/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/15/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)

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