Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 9:11 p.m.

The MLB's Tuesday slate includes the Chicago Cubs taking on the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Cubs vs Padres Game Info

• Chicago Cubs (17-12) vs. San Diego Padres (19-9)
• Date: Tuesday, April 28, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and MARQ

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-118) | SD: (+100)
• Spread: CHC: -1.5 (+132) | SD: +1.5 (-160)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Edward Cabrera (Cubs) - 2-0, 2.73 ERA vs Walker Buehler (Padres) - 1-2, 5.75 ERA

The Cubs will give the ball to Edward Cabrera (2-0, 2.73 ERA), who is eyeing win No. 3 on the season, and the Padres will counter with Walker Buehler (1-2, 5.75 ERA). Cabrera and his team have a record of 3-2-0 against the spread when he starts. Cabrera's team has won 75% of his starts when they are favored on the moneyline (3-1). The Padres have a 4-1-0 record against the spread in Buehler's starts. The Padres were the moneyline underdog for two Buehler starts this season -- they won both.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (58.3%)

Cubs vs Padres Moneyline

• The Cubs vs Padres moneyline has Chicago as a -118 favorite, while San Diego is a +100 underdog at home.

Cubs vs Padres Spread

• The Cubs are at the Padres and are favored by 1.5 runs on the spread. The Cubs are +132 to cover the runline, with the Padres being -160.

Cubs vs Padres Over/Under

• A combined run total of 8.5 has been set for Cubs-Padres on April 28, with the over at -108 and the under at -112.

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Cubs vs Padres Betting Trends

• The Cubs have been chosen as favorites in 18 games this year and have walked away with the win 11 times (61.1%) in those games.
• Chicago has a record of 9-7 when favored by -118 or more this year.
• The Cubs and their opponents have gone over the total this season in 18 of their 29 opportunities.
• The Cubs are 14-15-0 against the spread in their 29 games with a line set by sportsbooks this season.
• The Padres are 6-5 in games they were the underdog on the moneyline (winning 54.5% of those games).
• San Diego has a 5-5 record (winning 50% of its games) when it has played as a moneyline underdog of +100 or longer.
• The Padres have played in 28 games with a set over/under, and have combined with their opponents to go over the total 12 times (12-15-1).
• The Padres have collected an 18-10-0 record against the spread this season (covering 64.3% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago with an OBP of .375, plus a team-best slugging percentage of .458. He's batting .297 on the season.
• Among all qualifying hitters in MLB, he is 26th in batting average, 24th in on-base percentage, and 56th in slugging.
• Dansby Swanson is hitting .206 with a double, a triple, six home runs and 20 walks, while slugging .423 with an on-base percentage of .339.
• His batting average ranks 153rd among qualified players, his on-base percentage 78th, and his slugging percentage 74th.
• Moises Ballesteros has 24 hits this season and has a slash line of .387/.435/.710.
• Ballesteros enters this game with five games in a row with at least one hit. During his last five outings he is hitting .412 with four doubles, two home runs, a walk and five RBIs.
• Ian Happ has 25 hits, which is tops among Chicago hitters this season, while batting .236 with 11 extra-base hits.

Padres Player Leaders

• Xander Bogaerts has put up a .360 on-base percentage and a .422 slugging percentage, both team-best numbers for the Padres. He's batting .284.
• He ranks 38th in batting average, 41st in on-base percentage and 76th in slugging percentage among all qualifying batters in MLB.
• Manny Machado has four doubles, four home runs and 17 walks while batting .232. He's slugging .400 with an on-base percentage of .342.
• Including all qualified hitters, he is 118th in batting average, 74th in on-base percentage and 92nd in slugging percentage.
• Ramon Laureano is hitting .255 with four doubles, two triples, four home runs and 10 walks.
• Jackson Merrill is batting .213 with six doubles, three home runs and nine walks.

Cubs vs Padres Head to Head

• 4/27/2026: 9-7 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/2/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/1/2025: 3-0 SD (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/30/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/15/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)

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