Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 1:11 p.m.

Wednesday's slate in the MLB includes a matchup between the Chicago Cubs and the San Diego Padres.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Padres Game Info

• Chicago Cubs (12-8) vs. San Diego Padres (14-4)
• Date: Wednesday, April 16, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MARQ

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-156) | SD: (+132)
• Spread: CHC: -1.5 (+108) | SD: +1.5 (-130)
• Total: 8 -- Over: (-114) | Under: (-106)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 1-1, 1.59 ERA vs Nick Pivetta (Padres) - 2-1, 1.59 ERA

The Cubs will call on Matthew Boyd (1-1) against the Padres and Nick Pivetta (2-1). Boyd's team is 1-2-0 against the spread in his starts this season. Boyd's team won his only start as a favorite this season. The Padres have a 2-1-0 record against the spread in Pivetta's starts. The Padres were named the moneyline underdog for one Pivetta start this season -- they lost.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56.2%)

Cubs vs Padres Moneyline

• San Diego is a +132 underdog on the moneyline, while Chicago is a -156 favorite on the road.

Cubs vs Padres Spread

• The Cubs are at the Padres and are favored by 1.5 runs (+108 to cover) on the runline. San Diego is -130 to cover.

Cubs vs Padres Over/Under

• The over/under for Cubs-Padres on April 16 is 8. The over is -114, and the under is -106.

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Cubs vs Padres Betting Trends

• The Cubs have won in seven of the nine contests they have been named as odds-on favorites in this year.
• Chicago has a record of 3-1 in contests when sportsbooks favor them by -156 or more on the moneyline.
• The Cubs and their opponents have gone over in 13 of their 20 games with a total set by sportsbooks this season.
• The Cubs are 11-9-0 against the spread in their 20 games with a line set by sportsbooks this season.
• The Padres have won four of the seven games they were listed as the moneyline underdog this season (57.1%).
• San Diego has played as a moneyline underdog of +132 or longer in just one game this season, which it lost.
• The Padres have had an over/under set by bookmakers 18 times, and have combined with opponents to go over the total in eight of those games (8-9-1).
• The Padres have a 13-5-0 record against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago OPS (1.027) this season. He has a .313 batting average, an on-base percentage of .427, and a slugging percentage of .600.
• Among qualifying hitters, he is 24th in batting average, his on-base percentage ranks 10th, and he is 13th in slugging.
• Carson Kelly has a double, a triple, four home runs and 11 walks. He's batting .417 and slugging 1.042 with an on-base percentage of .595.
• Michael Busch has 19 hits and is batting .302 this season.
• Busch brings a four-game hitting streak into this game. During his last five outings he is hitting .364 with three doubles, three home runs, a walk and six RBI.
• Nico Hoerner has no home runs, but 11 RBI and a batting average of .328 this season.
• Hoerner enters this game on a four-game hitting streak. During his last five outings he is batting .333 with a double, a triple and three RBI.

Padres Player Leaders

• Fernando Tatis Jr. has racked up a team-high OBP (.427) and slugging percentage (.646), while leading the Padres in hits (23, while batting .354).
• Including all the qualified hitters in the majors, his batting average places him seventh, his on-base percentage is 10th, and he is seventh in slugging.
• Tatis enters this game on a five-game hitting streak. In his last five games he is batting .333 with four home runs, two walks and five RBI.
• Manny Machado has seven doubles, two home runs and eight walks while hitting .313. He's slugging .507 with an on-base percentage of .387.
• His batting average ranks 24th among all qualified players, his on-base percentage is 32nd, and he is 42nd in slugging.
• Luis Arraez has three doubles, two home runs and three walks while batting .280.
• Xander Bogaerts is hitting .270 with five doubles and nine walks.

Cubs vs Padres Head to Head

• 4/15/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/8/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/7/2024: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2024: 6-3 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/10/2024: 10-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/9/2024: 5-1 CHC (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)

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