Cubs vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 2:11 p.m.

The Chicago Cubs versus the Seattle Mariners is on the MLB schedule for Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Cubs vs Mariners Game Info

• Chicago Cubs (45-30) vs. Seattle Mariners (38-36)
• Date: Saturday, June 21, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and ROOT Sports NW

Cubs vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-166) | SEA: (+140)
• Spread: CHC: -1.5 (+108) | SEA: +1.5 (-130)
• Total: 12.5 -- Over: (-115) | Under: (-105)

Cubs vs Mariners Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 3-1, 3.47 ERA vs Emerson Hancock (Mariners) - 3-2, 4.48 ERA

The Cubs will look to Cade Horton (3-1) against the Mariners and Emerson Hancock (3-2). Horton's team is 3-3-0 against the spread in his starts this season. Horton's team has won 80% of his starts when they are favored on the moneyline (4-1). The Mariners are 8-4-0 against the spread when Hancock starts. The Mariners are 5-2 in Hancock's seven starts this season that they were the underdog on the moneyline.

Cubs vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.6%)

Cubs vs Mariners Moneyline

• Seattle is a +140 underdog on the moneyline, while Chicago is a -166 favorite at home.

Cubs vs Mariners Spread

• The Cubs are favored by 1.5 runs at home versus the Mariners. The Cubs are +108 to cover the spread, while the Mariners are -130.

Cubs vs Mariners Over/Under

• An over/under of 12.5 has been set for Cubs-Mariners on June 21, with the over being -115 and the under -105.

Bet on Chicago Cubs vs. Seattle Mariners on FanDuel today!

Cubs vs Mariners Betting Trends

• The Cubs have been favorites in 48 games this season and have come away with the win 34 times (70.8%) in those contests.
• This season Chicago has come away with a win 13 times in 18 chances when named as a favorite of at least -166 on the moneyline.
• The Cubs' games have gone over the total in 38 of their 73 opportunities.
• In 73 games with a line this season, the Cubs have a mark of 37-36-0 against the spread.
• The Mariners have won 52% of the games this season they were the moneyline underdog (13-12).
• Seattle has gone 2-2 when it has played as a moneyline underdog with odds of +140 or longer (50%).
• The Mariners have combined with opponents to go over the total 38 times this season for a 38-31-4 record against the over/under.
• The Mariners have a 32-41-0 record ATS this season (covering 43.8% of the time).

Cubs Player Leaders

• Kyle Tucker has 78 hits this season and a team-best OBP of .395. He has a .284 batting average and a slugging percentage of .513.
• Among qualifying hitters in baseball, his batting average ranks 30th, his on-base percentage ranks seventh, and he is 17th in slugging.
• Pete Crow-Armstrong leads Chicago with 77 hits. He is batting .266 this season and has 39 extra-base hits. He's also slugging .550 with an on-base percentage of .305.
• He is 59th in batting average, 122nd in on-base percentage and eighth in slugging in MLB.
• Seiya Suzuki has collected 73 base hits, an OBP of .314 and a slugging percentage of .528 this season.
• Nico Hoerner leads Chicago in slugging percentage (.356) thanks to 18 extra-base hits.
• Hoerner takes a six-game hitting streak into this matchup. In his last 10 outings he is batting .297 with two doubles, a walk and two RBIs.

Mariners Player Leaders

• Cal Raleigh has racked up 74 hits, a team-best for the Mariners. He's batting .273 and slugging .646 with an on-base percentage of .379.
• Including all qualifying players in the big leagues, he is 45th in batting average, 17th in on-base percentage and second in slugging percentage.
• Raleigh hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .400 with two doubles, three home runs, a walk and nine RBIs.
• Julio Rodriguez's .403 slugging percentage leads his team. He has a batting average of .253 with an on-base percentage of .315.
• Including all qualified players, he ranks 87th in batting average, 104th in on-base percentage and 104th in slugging percentage.
• J.P. Crawford a has .409 on-base percentage to lead the Mariners.
• Jorge Polanco is hitting .254 with eight doubles, 11 home runs and 13 walks.

Cubs vs Mariners Head to Head

• 6/20/2025: 9-4 SEA (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/14/2024: 3-2 CHC (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/13/2024: 4-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/12/2024: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/12/2023: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 11, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/11/2023: 14-9 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/10/2023: 3-2 CHC (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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