Cubs vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 7:11 p.m.

The Chicago Cubs are among the MLB teams playing on Monday, versus the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Giants Game Info

• Chicago Cubs (21-14) vs. San Francisco Giants (22-13)
• Date: Monday, May 5, 2025
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and NBCS-BA

Cubs vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-172) | SF: (+144)
• Spread: CHC: -1.5 (+118) | SF: +1.5 (-142)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Cubs vs Giants Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 2-2, 2.70 ERA vs Landen Roupp (Giants) - 2-2, 5.10 ERA

The Cubs will look to Matthew Boyd (2-2) against the Giants and Landen Roupp (2-2). Boyd and his team are 1-5-0 ATS this season when he starts. Boyd's team has won 66.7% of his starts when they are favored on the moneyline (2-1). The Giants are 2-4-0 ATS in Roupp's six starts with a set spread. The Giants have been the underdog on the moneyline in three of Roupp's starts this season, and they went 2-1 in those games.

Cubs vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (51.4%)

Cubs vs Giants Moneyline

• San Francisco is a +144 underdog on the moneyline, while Chicago is a -172 favorite at home.

Cubs vs Giants Spread

• The Giants are at +1.5 on the runline against the Cubs. The Giants are -142 to cover the spread, and the Cubs are +118.

Cubs vs Giants Over/Under

• The Cubs-Giants contest on May 5 has been given an over/under of 7.5 runs. The over is set at -100 and the under at -122.

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Cubs vs Giants Betting Trends

• The Cubs have come away with 12 wins in the 16 contests they have been listed as the favorites in this season.
• Chicago has been listed as a favorite of -172 or more on two occasions this season and lost both games.
• The Cubs and their opponents have gone over in 21 of their 33 games with a total set by sportsbooks this season.
• The Cubs are 18-15-0 against the spread in their 33 games that had a posted line this season.
• The Giants have been the underdog on the moneyline 12 total times this season. They've finished 6-6 in those games.
• San Francisco has played as a moneyline underdog of +144 or longer in only one game this season, which it lost.
• The Giants have played in 35 games with an over/under set, and have combined with opponents to go over the total 20 times (20-14-1).
• The Giants have a 17-18-0 record against the spread this season (covering 48.6% of the time).

Cubs Player Leaders

• Kyle Tucker has 40 hits and an OBP of .399, both of which are best among Chicago hitters this season. He has a .292 batting average and a slugging percentage of .577.
• Among all qualified hitters in MLB, he is 26th in batting average, eighth in on-base percentage, and sixth in slugging.
• Tucker will look for his fifth straight game with a hit in this matchup. During his last five outings he is hitting .316 with two home runs, three walks and four RBI.
• Pete Crow-Armstrong has 10 doubles, a triple, nine home runs and six walks. He's batting .272 and slugging .559 with an on-base percentage of .308.
• His batting average is 51st among qualified players, his on-base percentage 105th, and his slugging percentage 13th.
• Crow-Armstrong has picked up at least one hit in three games in a row. In his last five games he is batting .200 with three home runs and five RBI.
• Carson Kelly has 21 hits this season and has a slash line of .368/.513/.807.
• Kelly has picked up a hit in five games in a row. During his last five outings he is hitting .421 with a double, a home run, three walks and four RBI.
• Ian Happ leads Chicago with a slugging percentage of .388, fueled by 11 extra-base hits.
• Happ enters this game on a six-game hitting streak. During his last 10 outings he is batting .325 with four doubles, six walks and three RBI.

Giants Player Leaders

• Jung Hoo Lee has a team-high slugging percentage (.492) and paces the Giants in hits (39). He's batting .305 and with an on-base percentage of .362.
• Including all qualified hitters in the big leagues, he is 16th in batting average, 40th in on-base percentage and 30th in slugging percentage.
• Michael Yastrzemski paces his team with a .387 on-base percentage. He has a batting average of .283 while slugging .491.
• He ranks 37th in batting average, 18th in on-base percentage and 31st in slugging percentage in the big leagues.
• Matt Chapman is hitting .198 with four doubles, seven home runs and 27 walks.
• Wilmer Flores has two doubles, seven home runs and seven walks while batting .240.

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