Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 5

Odds updated as of 2:12 p.m.

The Chicago Cubs will take on the St. Louis Cardinals in MLB action on Saturday.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Cardinals Game Info

• Chicago Cubs (53-35) vs. St. Louis Cardinals (47-42)
• Date: Saturday, July 5, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and FDSMW

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-164) | STL: (+138)
• Spread: CHC: -1.5 (+118) | STL: +1.5 (-142)
• Total: 11 -- Over: (-118) | Under: (-104)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Drew Pomeranz (Cubs) - 2-1, 0.00 ERA vs Matthew Liberatore (Cardinals) - 6-6, 3.70 ERA

The Cubs will give the ball to Drew Pomeranz (2-1, 0.00 ERA), who is eyeing win No. 3 on the season, and the Cardinals will counter with Matthew Liberatore (6-6, 3.70 ERA). Pomeranz has a record of 2-0-0 ATS in two starts with a spread this season. Pomeranz's team is 2-0 this season when he starts and they're favored on the moneyline. When Liberatore starts, the Cardinals are 7-9-0 against the spread. The Cardinals have been the underdog on the moneyline in five of Liberatore's starts this season, and they went 4-1 in those matchups.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.3%)

Cubs vs Cardinals Moneyline

• The Cubs vs Cardinals moneyline has Chicago as a -164 favorite, while St. Louis is a +138 underdog on the road.

Cubs vs Cardinals Spread

• The Cubs are favored by 1.5 runs at home versus the Cardinals. The Cubs are +118 to cover the spread, while the Cardinals are -142.

Cubs vs Cardinals Over/Under

• Cubs versus Cardinals, on July 5, has an over/under of 11, with the over being -118 and the under -104.

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Cubs vs Cardinals Betting Trends

• The Cubs have been chosen as favorites in 57 games this year and have walked away with the win 41 times (71.9%) in those games.
• Chicago has a record of 15-5 when favored by -164 or more this year.
• The Cubs and their opponents have gone over the total this season in 46 of their 86 opportunities.
• The Cubs have posted a record of 43-43-0 against the spread this season.
• The Cardinals have won 51% of the games this season they were the moneyline underdog (25-24).
• St. Louis has a record of 3-6 in games it has played as a moneyline underdog with odds of +138 or longer (33.3%).
• The Cardinals have played in 88 games with a set over/under, and have combined with their opponents to go over the total 45 times (45-40-3).
• The Cardinals have gone 48-40-0 against the spread this season.

Cubs Player Leaders

• Kyle Tucker has an OPS of .906, fueled by an OBP of .388 to go with a slugging percentage of .518. He has a .284 batting average, as well.
• Among qualifying hitters, he ranks 31st in batting average, his on-base percentage ranks sixth, and he is 15th in slugging.
• Pete Crow-Armstrong leads Chicago in slugging percentage (.559) and total hits (93) this season. He's batting .274 with an on-base percentage of .309.
• Among all qualified, he ranks 48th in batting average, 113th in on-base percentage and seventh in slugging percentage.
• Seiya Suzuki has collected 88 base hits, an OBP of .317 and a slugging percentage of .552 this season.
• Suzuki heads into this game with four games in a row with at least one hit. In his last five games he is hitting .263 with a double, two home runs, two walks and five RBIs.
• Michael Busch has been key for Chicago with 78 hits, an OBP of .373 plus a slugging percentage of .546.

Cardinals Player Leaders

• Brendan Donovan has put up an on-base percentage of .364 and a slugging percentage of .430. Both lead the Cardinals. He's batting .293.
• Including all qualified hitters, he ranks 14th in batting average, while his on-base percentage is 26th and he is 74th in slugging.
• Donovan hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .158 with a double, a home run, two walks and an RBI.
• Nolan Arenado is batting .244 with 13 doubles, a triple, 10 home runs and 24 walks. He's slugging .391 with an on-base percentage of .304.
• He is currently 114th in batting average, 119th in on-base percentage and 110th in slugging percentage among all qualifying hitters.
• Willson Contreras is batting .246 with 19 doubles, 11 home runs and 29 walks.
• Lars Nootbaar is hitting .227 with 13 doubles, 11 home runs and 46 walks.

Cubs vs Cardinals Head to Head

• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 6-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/14/2024: 8-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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