Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 28

Odds updated as of 7:12 p.m.

In MLB action on Tuesday, the Chicago Cubs face the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Cubs vs Cardinals Game Info

• Chicago Cubs (60-46) vs. St. Louis Cardinals (53-53)
• Date: Tuesday, July 28, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: TBS, Cardinals.TV, and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-122) | STL: (+104)
• Spread: CHC: -1.5 (+128) | STL: +1.5 (-154)
• Total: 9.5 -- Over: (+100) | Under: (-122)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 7-7, 4.85 ERA vs Michael McGreevy (Cardinals) - 4-8, 3.07 ERA

The Cubs will give the nod to Colin Rea (7-7) against the Cardinals and Michael McGreevy (4-8). Rea and his team have a record of 5-12-0 against the spread when he starts. When Rea starts a game and his team is the favorite on the moneyline, they have a record of 4-7. The Cardinals have a 10-10-0 ATS record in McGreevy's 20 starts that had a set spread. The Cardinals have a 7-7 record in McGreevy's 14 starts this season when they were the moneyline underdog.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.1%)

Cubs vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Cubs, St. Louis is the underdog at +104, and Chicago is -122 playing on the road.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-154 to cover), and Chicago is +128 to cover the runline.

Cubs vs Cardinals Over/Under

• The over/under for Cubs-Cardinals on July 28 is 9.5. The over is +100, and the under is -122.

Bet on Chicago Cubs vs. St. Louis Cardinals on FanDuel today!

Cubs vs Cardinals Betting Trends

• The Cubs have been chosen as favorites in 67 games this year and have walked away with the win 38 times (56.7%) in those games.
• This year Chicago has won 29 of 54 games when listed as at least -122 on the moneyline.
• The Cubs and their opponents have hit the over in 55 of their 101 games with a total set by oddsmakers this season.
• In 101 games with a line this season, the Cubs have a mark of 46-55-0 against the spread.
• The Cardinals have won 34 of the 71 games they were the moneyline underdog this season (47.9%).
• In games it has played as a moneyline underdog with odds of +104 or longer, St. Louis has a 26-25 record (winning 51% of its games).
• The Cardinals have had an over/under set by bookmakers 103 times, and have combined with opponents to go over the total in 41 of those games (41-56-6).
• The Cardinals have gone 57-46-0 ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago with 114 hits and an OBP of .388, plus a team-best slugging percentage of .540. He's batting .288.
• Among all qualifying hitters in baseball, he ranks 17th in batting average, seventh in on-base percentage, and 11th in slugging.
• Nico Hoerner is batting .254 with 23 doubles, a triple, five home runs and 36 walks, while slugging .349 with an on-base percentage of .317.
• His batting average ranks 77th among qualified players, his on-base percentage 99th, and his slugging percentage 140th.
• Hoerner heads into this game looking to extend his four-game hit streak. During his last five outings he is batting .381 with a home run and five RBIs.
• Dansby Swanson has 77 hits this season and has a slash line of .220/.299/.411.
• Swanson has logged a hit or more in four games in a row. During his last five outings he is hitting .316 with a double, a walk and three RBIs.
• Alex Bregman has been key for Chicago with 98 hits, an OBP of .336 plus a slugging percentage of .369.

Cardinals Player Leaders

• Jordan Walker is leading the Cardinals with 114 hits. He's batting .285 and slugging .508 with an on-base percentage of .348.
• Including all the qualifying hitters in the majors, his batting average ranks 20th, his on-base percentage is 51st, and he is 16th in slugging.
• Alec Burleson's .467 slugging percentage paces his team. He has a batting average of .286 with an on-base percentage of .345.
• He is currently 19th in batting average, 57th in on-base percentage and 40th in slugging percentage among all qualifying batters.
• JJ Wetherholt is hitting .253 with 10 doubles, 15 home runs and 45 walks.
• Ivan Herrera leads his team with a .365 on-base percentage.

Cubs vs Cardinals Head to Head

• 7/5/2026: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/3/2026: 17-1 STL (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/31/2026: 5-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/30/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2026: 6-5 STL (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/28/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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