Cubs vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 2:11 p.m.

The Chicago Cubs versus the Houston Astros is on the MLB schedule for Friday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cubs vs Astros Game Info

• Chicago Cubs (29-21) vs. Houston Astros (20-31)
• Date: Friday, May 22, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: Apple TV+

Cubs vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-142) | HOU: (+120)
• Spread: CHC: -1.5 (+160) | HOU: +1.5 (-194)
• Total: 7 -- Over: (-102) | Under: (-120)

Cubs vs Astros Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 2-3, 4.97 ERA vs Spencer Arrighetti (Astros) - 5-1, 1.50 ERA

The probable starters are Jameson Taillon (2-3) for the Cubs and Spencer Arrighetti (5-1) for the Astros. Taillon and his team are 2-7-0 ATS this season when he starts. Taillon's team has a record of 3-1 this season when he starts and they are the favorite on the moneyline. The Astros are 5-1-0 against the spread when Arrighetti starts. The Astros have a 4-1 record in Arrighetti's five starts this season when they were the underdog on the moneyline.

Cubs vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.2%)

Cubs vs Astros Moneyline

• Looking at the moneyline for Cubs-Astros, Chicago is the favorite at -142, and Houston is +120 playing on the road.

Cubs vs Astros Spread

• The Cubs are hosting the Astros and are favored by 1.5 runs (+160 to cover) on the runline. Houston is -194 to cover.

Cubs vs Astros Over/Under

• A combined run total of 7 has been set for Cubs-Astros on May 22, with the over at -102 and the under at -120.

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Cubs vs Astros Betting Trends

• The Cubs have won in 20, or 62.5%, of the 32 contests they have been named as odds-on favorites in this year.
• This season Chicago has come away with a win 12 times in 18 chances when named as a favorite of at least -142 on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 28 of 49 chances this season.
• The Cubs are 21-28-0 against the spread in their 49 games that had a posted line this season.
• The Astros have won 14 of the 34 games they were the underdog on the moneyline this season (41.2%).
• When playing as a moneyline underdog with odds of +120 or longer, Houston has a 5-12 record (winning only 29.4% of its games).
• In the 51 games oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total 28 times (28-21-2).
• The Astros have collected a 20-31-0 record ATS this season (covering just 39.2% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago in slugging percentage (.391) thanks to 17 extra-base hits. He has a .264 batting average and an on-base percentage of .348.
• Among all qualifying hitters, he is 64th in batting average, his on-base percentage ranks 63rd, and he is 96th in slugging.
• Hoerner has recorded a base hit in two straight games. During his last five outings he is hitting .263 with a double, five walks and an RBI.
• Dansby Swanson has four doubles, a triple, seven home runs and 24 walks. He's batting .191 and slugging .358 with an on-base percentage of .295.
• His batting average is 161st among qualified players, his on-base percentage 135th, and his slugging percentage 132nd.
• Michael Busch has collected 41 base hits, an OBP of .360 and a slugging percentage of .375 this season.
• Ian Happ has been key for Chicago with 38 hits, an OBP of .353 plus a slugging percentage of .429.

Astros Player Leaders

• Yordan Alvarez has a team-best OBP (.412) and slugging percentage (.605), while leading the Astros in hits (56, while batting .303).
• Including all the qualified hitters in the big leagues, his batting average places him 12th, his on-base percentage is fifth, and he is fourth in slugging.
• Christian Walker is hitting .255 with 10 doubles, 11 home runs and 18 walks. He's slugging .489 with an on-base percentage of .330.
• Including all qualifying hitters, he is 78th in batting average, 81st in on-base percentage and 30th in slugging percentage.
• Isaac Paredes has seven doubles, five home runs and 16 walks while batting .244.
• Cam Smith is hitting .206 with six doubles, four home runs and 19 walks.

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