Cubs vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 9:12 p.m.

The Friday schedule in MLB includes a matchup between the Chicago Cubs and the Houston Astros.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Astros Game Info

• Chicago Cubs (29-21) vs. Houston Astros (20-31)
• Date: Friday, May 22, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: Apple TV+

Cubs vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-142) | HOU: (+120)
• Spread: CHC: -1.5 (+158) | HOU: +1.5 (-194)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Cubs vs Astros Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 2-3, 4.97 ERA vs Spencer Arrighetti (Astros) - 5-1, 1.50 ERA

The Cubs will give the nod to Jameson Taillon (2-3) against the Astros and Spencer Arrighetti (5-1). Taillon's team is 2-7-0 against the spread this season in his starts. Taillon's team has been victorious in 75% of the games he's started as the moneyline favorite with a record of 3-1. The Astros are 5-1-0 against the spread when Arrighetti starts. The Astros have been the moneyline underdog in five of Arrighetti's starts this season, and they went 4-1 in those matchups.

Cubs vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.9%)

Cubs vs Astros Moneyline

• The moneyline numbers for Cubs vs. Astros reveal Chicago as the favorite (-142) and Houston as the underdog (+120) on the road.

Cubs vs Astros Spread

• The Astros are at the Cubs, and are +1.5 on the runline. The Astros are +158 to cover the spread, and the Cubs are -194.

Cubs vs Astros Over/Under

• A combined run total of 7.5 has been set for Cubs-Astros on May 22, with the over at +100 and the under at -122.

Bet on Chicago Cubs vs. Houston Astros on FanDuel today!

Cubs vs Astros Betting Trends

• The Cubs have been chosen as favorites in 32 games this year and have walked away with the win 20 times (62.5%) in those games.
• This season Chicago has come away with a win 12 times in 18 chances when named as a favorite of at least -142 on the moneyline.
• The Cubs and their opponents have hit the over in 28 of their 49 games with a total set by oddsmakers this season.
• The Cubs have posted a record of 21-28-0 against the spread this season.
• The Astros are 14-20 in games they were the underdog on the moneyline (winning 41.2% of those games).
• Houston has gone 5-12 when playing as a moneyline underdog with odds of +120 or longer (29.4%).
• The Astros have combined with opponents to hit the over on the total 28 times this season for a 28-21-2 record against the over/under.
• The Astros have a 20-31-0 record ATS this season (covering only 39.2% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago with a slugging percentage of .391, fueled by 17 extra-base hits. He has a .264 batting average and an on-base percentage of .348.
• He ranks 64th in batting average, 64th in on-base percentage, and 97th in slugging among all qualified hitters in baseball.
• Hoerner has recorded a base hit in two straight games. In his last five games he is batting .263 with a double, five walks and an RBI.
• Dansby Swanson has four doubles, a triple, seven home runs and 24 walks. He's batting .191 and slugging .358 with an on-base percentage of .295.
• Among qualified hitters, he is 161st in batting average, 134th in on-base percentage and 132nd in slugging percentage.
• Michael Busch has 41 hits this season and has a slash line of .233/.360/.375.
• Ian Happ is batting .215 with a .353 OBP and 20 RBI for Chicago this season.

Astros Player Leaders

• Yordan Alvarez has an on-base percentage of .412, a slugging percentage of .605, and has 56 hits, all club-bests for the Astros (while batting .303).
• Including all qualifying hitters in the big leagues, he ranks 12th in batting average, fifth in on-base percentage and fourth in slugging percentage.
• Christian Walker is hitting .255 with 10 doubles, 11 home runs and 18 walks. He's slugging .489 with an on-base percentage of .330.
• Including all qualified players, he ranks 78th in batting average, 82nd in on-base percentage and 32nd in slugging percentage.
• Isaac Paredes is batting .244 with seven doubles, five home runs and 16 walks.
• Cam Smith is hitting .206 with six doubles, four home runs and 19 walks.

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