Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 19

Odds updated as of 2:12 p.m.

The St. Louis Cardinals are among the MLB teams playing on Thursday, versus the Chicago White Sox.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (38-35) vs. Chicago White Sox (23-50)
• Date: Thursday, June 19, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and FDSMW

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-166) | CHW: (+140)
• Spread: STL: -1.5 (-102) | CHW: +1.5 (-118)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Erick Fedde (Cardinals) - 3-6, 3.65 ERA vs Sean Burke (White Sox) - 3-7, 4.71 ERA

The Cardinals will give the nod to Erick Fedde (3-6) versus the White Sox and Sean Burke (3-7). Fedde and his team have a record of 8-6-0 against the spread when he starts. Fedde has started three games with his team as the moneyline favorite, and has been upset each time. The White Sox have gone 8-4-0 ATS in Burke's 12 starts with a set spread. The White Sox are 6-6 in Burke's 12 starts this season that they were the underdog on the moneyline.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (60.7%)

Cardinals vs White Sox Moneyline

• Looking at the moneyline for Cardinals-White Sox, St. Louis is the favorite at -166, and Chicago is +140 playing at home.

Cardinals vs White Sox Spread

• The Cardinals are at the White Sox and are favored by 1.5 runs on the spread. The Cardinals are -102 to cover the runline, with the White Sox being -118.

Cardinals vs White Sox Over/Under

• The Cardinals-White Sox game on June 19 has been given an over/under of 8.5 runs. The over is set at -115 and the under at -105.

Bet on St. Louis Cardinals vs. Chicago White Sox on FanDuel today!

Cardinals vs White Sox Betting Trends

• The Cardinals have been chosen as favorites in 31 games this year and have walked away with the win 15 times (48.4%) in those games.
• St. Louis has been listed as a favorite of -166 or more on two occasions this season and won both games.
• The Cardinals and their opponents have gone over the total this season in 39 of their 73 opportunities.
• The Cardinals are 40-33-0 against the spread in their 73 games that had a posted line this season.
• The White Sox have gone 21-48 in games they were the underdog on the moneyline (winning 30.4% of those games).
• Chicago has a 12-35 record (winning only 25.5% of its games) when playing as a moneyline underdog of +140 or longer.
• The White Sox have played in 70 games with a set over/under, and have combined with their opponents to go over the total 33 times (33-34-3).
• The White Sox have a 39-31-0 record ATS this season (covering 55.7% of the time).

Cardinals Player Leaders

• Brendan Donovan has 83 hits and an OBP of .388 to go with a slugging percentage of .451. All three of those stats lead St. Louis hitters this season. He has a .323 batting average, as well.
• Among qualifying batters, he ranks sixth in batting average, his on-base percentage ranks 10th, and he is 56th in slugging.
• Donovan hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .409 with two doubles and an RBI.
• Nolan Arenado is batting .244 with 11 doubles, a triple, eight home runs and 22 walks, while slugging .388 with an on-base percentage of .306.
• His batting average is 100th among qualified players, his on-base percentage 115th, and his slugging percentage 116th.
• Arenado has picked up a hit in seven games in a row. During his last 10 games he is hitting .286 with a double, a home run, two walks and five RBIs.
• Willson Contreras has 64 hits this season and has a slash line of .248/.337/.411.
• Lars Nootbaar is batting .223 with a .330 OBP and 28 RBI for St. Louis this season.

White Sox Player Leaders

• Miguel Vargas has racked up an on-base percentage of .321, a slugging percentage of .441, and has 62 hits, all club-bests for the White Sox (while batting .242).
• Including all the qualifying hitters in the majors, his batting average is 105th, his on-base percentage is 92nd, and he is 68th in slugging.
• Vargas heads into this matchup on a six-game hitting streak. During his last 10 games he is batting .270 with four doubles, a triple, two home runs, five walks and five RBIs.
• Chase Meidroth is hitting .276 with five doubles, two home runs and 23 walks. He's slugging .337 with an on-base percentage of .358.
• Andrew Benintendi is hitting .235 with nine doubles, a triple, six home runs and 15 walks.
• Luis Robert is hitting .190 with eight doubles, six home runs and 26 walks.

Cardinals vs White Sox Head to Head

• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2023: 8-7 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)

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