Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 19

Odds updated as of 1:13 a.m.

The St. Louis Cardinals will take on the Chicago White Sox in MLB action on Thursday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (38-35) vs. Chicago White Sox (23-50)
• Date: Thursday, June 19, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and FDSMW

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-144) | CHW: (+122)
• Spread: STL: -1.5 (+114) | CHW: +1.5 (-137)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Erick Fedde (Cardinals) - 3-6, 3.65 ERA vs Sean Burke (White Sox) - 3-7, 4.71 ERA

The Cardinals will give the ball to Erick Fedde (3-6, 3.65 ERA), who is eyeing win No. 4 on the season, and the White Sox will counter with Sean Burke (3-7, 4.71 ERA). Fedde and his team are 8-6-0 ATS this season when he starts. Fedde has started three games with his team as the moneyline favorite, and has been upset each time. The White Sox are 8-4-0 against the spread when Burke starts. The White Sox are 6-6 in Burke's 12 starts this season that they were the underdog on the moneyline.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (56.6%)

Cardinals vs White Sox Moneyline

• St. Louis is the favorite, -144 on the moneyline, while Chicago is a +122 underdog despite being at home.

Cardinals vs White Sox Spread

• The Cardinals are favored by 1.5 runs on the road against the White Sox. The Cardinals are +114 to cover the spread, while the White Sox are -137.

Cardinals vs White Sox Over/Under

• Cardinals versus White Sox, on June 19, has an over/under of 8.5, with the over being -110 and the under -110.

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Cardinals vs White Sox Betting Trends

• The Cardinals have been chosen as favorites in 31 games this year and have walked away with the win 15 times (48.4%) in those games.
• St. Louis has a record of 4-2 in contests when oddsmakers favor them by -144 or more on the moneyline.
• The Cardinals and their opponents have hit the over in 39 of their 73 games with a total set by oddsmakers this season.
• The Cardinals have posted a record of 40-33-0 against the spread this season.
• The White Sox have won 21 of the 69 games they were the moneyline underdog this season (30.4%).
• When playing as a moneyline underdog with odds of +122 or longer, Chicago has an 18-43 record (winning just 29.5% of its games).
• The White Sox have had an over/under set by oddsmakers 70 times, and have combined with opponents to go over the total in 33 of those games (33-34-3).
• The White Sox have put together a 39-31-0 record ATS this season (covering 55.7% of the time).

Cardinals Player Leaders

• Brendan Donovan leads St. Louis in OBP (.388), slugging percentage (.451) and total hits (83) this season. He has a .323 batting average.
• Among qualified hitters in the majors, his batting average ranks sixth, his on-base percentage ranks 10th, and he is 56th in slugging.
• Donovan will look for his third straight game with a hit in this matchup. In his last five games he is batting .409 with two doubles and an RBI.
• Nolan Arenado is hitting .244 with 11 doubles, a triple, eight home runs and 22 walks. He's slugging .388 with an on-base percentage of .306.
• Among all qualified batters, he ranks 100th in batting average, 115th in on-base percentage and 116th in slugging percentage.
• Arenado has picked up at least one hit in seven straight games. During his last 10 games he is batting .286 with a double, a home run, two walks and five RBIs.
• Willson Contreras is batting .248 with a .411 slugging percentage and 45 RBI this year.
• Lars Nootbaar has been key for St. Louis with 60 hits, an OBP of .330 plus a slugging percentage of .357.

White Sox Player Leaders

• Miguel Vargas has totaled 62 hits with a .321 on-base percentage and a .441 slugging percentage, all club-highs for the White Sox. He's batting .242.
• Including all the qualifying hitters in MLB, his batting average ranks 105th, his on-base percentage ranks 92nd, and he is 68th in slugging.
• Vargas brings a six-game hitting streak into this matchup. During his last 10 games he is hitting .270 with four doubles, a triple, two home runs, five walks and five RBIs.
• Chase Meidroth has five doubles, two home runs and 23 walks while hitting .276. He's slugging .337 with an on-base percentage of .358.
• Andrew Benintendi is hitting .235 with nine doubles, a triple, six home runs and 15 walks.
• Luis Robert is batting .190 with eight doubles, six home runs and 26 walks.

Cardinals vs White Sox Head to Head

• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2023: 8-7 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)

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