Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 17

Odds updated as of 7:11 p.m.

The St. Louis Cardinals versus the Chicago White Sox is on the MLB schedule for Tuesday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (37-35) vs. Chicago White Sox (23-49)
• Date: Tuesday, June 17, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and FDSMW

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-132) | CHW: (+112)
• Spread: STL: -1.5 (+118) | CHW: +1.5 (-142)
• Total: 9 -- Over: (-115) | Under: (-105)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 3-6, 4.17 ERA vs Shane Smith (White Sox) - 3-3, 2.37 ERA

The Cardinals will look to Matthew Liberatore (3-6) versus the White Sox and Shane Smith (3-3). Liberatore and his team are 4-9-0 ATS this season when he starts. Liberatore's team is 2-7 this season when he starts and they are the moneyline favorite. The White Sox have a 7-6-0 record against the spread in Smith's starts. The White Sox have a 4-8 record in Smith's 12 starts this season when they were the underdog on the moneyline.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57.7%)

Cardinals vs White Sox Moneyline

• St. Louis is a -132 favorite on the moneyline, while Chicago is a +112 underdog at home.

Cardinals vs White Sox Spread

• The White Sox are +1.5 on the spread (-142 to cover), and St. Louis is +118 to cover the runline.

Cardinals vs White Sox Over/Under

• The over/under for Cardinals-White Sox on June 17 is 9. The over is -115, and the under is -105.

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Cardinals vs White Sox Betting Trends

• The Cardinals have been victorious in 14, or 46.7%, of the 30 contests they have been chosen as favorites in this season.
• St. Louis has a record of 6-5 when favored by -132 or more this year.
• The Cardinals and their opponents have gone over the total this season in 38 of their 72 opportunities.
• The Cardinals are 39-33-0 against the spread in their 72 games with a line set by sportsbooks this season.
• The White Sox have a 21-47 record in games they were listed as the moneyline underdog (winning 30.9% of those games).
• Chicago has a 21-44 record (winning only 32.3% of its games) when playing as a moneyline underdog of +112 or longer.
• In the 69 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 32 times (32-34-3).
• The White Sox have a 39-30-0 record ATS this season (covering 56.5% of the time).

Cardinals Player Leaders

• Brendan Donovan leads St. Louis in OBP (.381), slugging percentage (.440) and total hits (79) this season. He has a .313 batting average.
• Among qualified hitters in MLB, his batting average ranks 10th, his on-base percentage ranks 15th, and he is 65th in slugging.
• Nolan Arenado is batting .243 with 11 doubles, a triple, eight home runs and 21 walks. He's slugging .388 with an on-base percentage of .304.
• Among all qualified hitters, he is 107th in batting average, 122nd in on-base percentage and 115th in slugging percentage.
• Arenado has picked up at least one hit in six straight games. In his last 10 outings he is batting .333 with a double, a home run, a walk and five RBIs.
• Willson Contreras is batting .251 with a .416 slugging percentage and 45 RBI this year.
• Lars Nootbaar is batting .226 with a .329 OBP and 28 RBI for St. Louis this season.

White Sox Player Leaders

• Miguel Vargas has a team-best OBP (.322) and slugging percentage (.440), while pacing the White Sox in hits (61, while batting .242).
• He ranks 112th in batting average, 92nd in on-base percentage and 65th in slugging percentage among all qualified hitters in the majors.
• Vargas takes a five-game hitting streak into this matchup. In his last five games he is batting .350 with three doubles, a triple, a home run, two walks and two RBIs.
• Chase Meidroth has five doubles, two home runs and 23 walks while hitting .282. He's slugging .345 with an on-base percentage of .365.
• Andrew Benintendi is batting .235 with nine doubles, a triple, six home runs and 15 walks.
• Luis Robert is batting .194 with eight doubles, six home runs and 26 walks.

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