Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 6

Odds updated as of 2:11 p.m.

On Saturday in MLB, the St. Louis Cardinals are up against the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Cardinals vs Reds Game Info

• St. Louis Cardinals (33-28) vs. Cincinnati Reds (31-31)
• Date: Saturday, June 6, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Reds.TV

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-142) | CIN: (+120)
• Spread: STL: -1.5 (+142) | CIN: +1.5 (-176)
• Total: 9.5 -- Over: (+102) | Under: (-124)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 3-3, 4.35 ERA vs Nick Lodolo (Reds) - 2-1, 5.20 ERA

The Cardinals will call on Matthew Liberatore (3-3) against the Reds and Nick Lodolo (2-1). Liberatore and his team have a record of 7-5-0 against the spread when he starts. Liberatore's team is 2-0 this season when he starts and they're favored on the moneyline. The Reds have gone 3-2-0 ATS in Lodolo's five starts with a set spread. The Reds have been the underdog on the moneyline in three of Lodolo's starts this season, and they went 2-1 in those matchups.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.5%)

Cardinals vs Reds Moneyline

• The Cardinals vs Reds moneyline has St. Louis as a -142 favorite, while Cincinnati is a +120 underdog on the road.

Cardinals vs Reds Spread

• The Reds are +1.5 on the run line against the Cardinals. The Reds are -176 to cover, and the Cardinals are +142.

Cardinals vs Reds Over/Under

• A combined run total of 9.5 has been set for Cardinals-Reds on June 6, with the over at +102 and the under at -124.

Bet on St. Louis Cardinals vs. Cincinnati Reds on FanDuel today!

Cardinals vs Reds Betting Trends

• The Cardinals have been chosen as favorites in 12 games this year and have walked away with the win seven times (58.3%) in those games.
• St. Louis has played as a favorite of -142 or more just one time this year and came away with a win in that game.
• Contests with the Cardinals have gone over the total set by sportsbooks in 26 of 60 chances this season.
• The Cardinals have posted a record of 36-24-0 against the spread this season.
• The Reds have put together a 20-18 record in games they were listed as the moneyline underdog (winning 52.6% of those games).
• Cincinnati has a 4-7 record (winning just 36.4% of its games) when playing as a moneyline underdog of +120 or longer.
• The Reds have played in 60 games with an over/under set, and have combined with opponents to go over the total 37 times (37-22-1).
• The Reds have a 33-27-0 record ATS this season (covering 55% of the time).

Cardinals Player Leaders

• Jordan Walker has 69 hits to go with a slugging percentage of .547, both of which lead St. Louis hitters this season. He has a .297 batting average and an on-base percentage of .359.
• Among all qualified hitters in baseball, he ranks 17th in batting average, 42nd in on-base percentage, and 10th in slugging.
• Walker has hit safely in three straight games. During his last five outings he is batting .364 with two doubles and three RBIs.
• Alec Burleson is hitting .291 with 15 doubles, eight home runs and 23 walks. He's slugging .457 with an on-base percentage of .356.
• Among qualifying hitters, he ranks 22nd in batting average, 48th in on-base percentage and 54th in slugging percentage.
• Burleson brings a six-game streak with at least one hit into this matchup. During his last 10 games he is batting .275 with two doubles, a home run, two walks and eight RBIs.
• Ivan Herrera leads St. Louis in OBP (.383) this season, fueled by 59 hits.
• Herrera takes a three-game hitting streak into this matchup. During his last five outings he is hitting .250 with two walks and an RBI.
• JJ Wetherholt has been key for St. Louis with 56 hits, an OBP of .357 plus a slugging percentage of .400.

Reds Player Leaders

• Sal Stewart a has .357 on-base percentage to lead the Reds. He's batting .263 while slugging .474.
• Including all the qualifying hitters in the majors, he is 60th in batting average, 45th in on-base percentage and 37th in slugging percentage.
• Spencer Steer is batting .274 with 12 doubles, nine home runs and 23 walks. He's slugging .458 with an on-base percentage of .351.
• He is currently 49th in batting average, 53rd in on-base percentage and 52nd in slugging percentage among all qualifying hitters.
• JJ Bleday is batting .286 with eight doubles, a triple, 10 home runs and 19 walks.
• Nathaniel Lowe is hitting .243 with nine doubles, nine home runs and 16 walks.

Cardinals vs Reds Head to Head

• 6/5/2026: 10-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2026: 7-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2026: 8-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/17/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/16/2025: 3-0 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2025: 11-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!