Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 5

Odds updated as of 5:12 a.m.

The MLB's Friday schedule includes the St. Louis Cardinals taking on the Cincinnati Reds.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Reds Game Info

• St. Louis Cardinals (32-28) vs. Cincinnati Reds (31-30)
• Date: Friday, June 5, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Reds.TV

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-138) | CIN: (+118)
• Spread: STL: -1.5 (+146) | CIN: +1.5 (-176)
• Total: 9.5 -- Over: (+100) | Under: (-122)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Kyle Leahy (Cardinals) - 5-3, 4.25 ERA vs Brady Singer (Reds) - 2-5, 6.18 ERA

The Cardinals will give the nod to Kyle Leahy (5-3, 4.25 ERA), who is eyeing win No. 6 on the season, and the Reds will turn to Brady Singer (2-5, 6.18 ERA). When Leahy starts, his team is 5-5-0 against the spread this season. Leahy's team lost his only start as a favorite this season. The Reds have a 6-4-0 record against the spread in Singer's starts. The Reds have been the moneyline underdog in eight of Singer's starts this season, and they went 4-4 in those matchups.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.5%)

Cardinals vs Reds Moneyline

• St. Louis is a -138 favorite on the moneyline, while Cincinnati is a +118 underdog on the road.

Cardinals vs Reds Spread

• The Reds are +1.5 on the run line against the Cardinals. The Reds are -176 to cover, and the Cardinals are +146.

Cardinals vs Reds Over/Under

• A combined run total of 9.5 has been set for Cardinals-Reds on June 5, with the over at +100 and the under at -122.

Bet on St. Louis Cardinals vs. Cincinnati Reds on FanDuel today!

Cardinals vs Reds Betting Trends

• The Cardinals have been favorites in 11 games this season and have come away with the win six times (54.5%) in those contests.
• Oddsmakers have given St. Louis the best odds of winning it has seen this season, with a -138 moneyline listed for this contest.
• The Cardinals' games have gone over the total in 25 of their 59 opportunities.
• The Cardinals are 35-24-0 against the spread in their 59 games with a line set by sportsbooks this season.
• The Reds have a 20-17 record in games they were listed as the moneyline underdog (winning 54.1% of those games).
• Cincinnati is 4-7 (winning only 36.4% of its games) when it has played as a moneyline underdog of +118 or longer.
• The Reds have combined with opponents to hit the over on the total 36 times this season for a 36-22-1 record against the over/under.
• The Reds have gone 33-26-0 against the spread this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis in slugging percentage (.537) and total hits (66) this season. He's batting .291 with an on-base percentage of .355.
• Among all qualifying hitters in the majors, he is 22nd in batting average, 46th in on-base percentage, and 11th in slugging.
• Walker hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .238 with two RBIs.
• Alec Burleson has an OPS of .795, fueled by an OBP of .352 and a team-best slugging percentage of .443 this season. He's batting .287.
• He ranks 26th in batting average, 51st in on-base percentage and 61st in slugging in the majors.
• Burleson enters this game looking to extend his five-game hit streak. In his last five games he is batting .400 with two doubles, a walk and seven RBIs.
• JJ Wetherholt is batting .249 with a .400 slugging percentage and 25 RBI this year.
• Ivan Herrera leads St. Louis with an OBP of .382 this season while batting .259 with 34 walks and 36 runs scored.
• Herrera takes a two-game hitting streak into this game. In his last five games he is hitting .200 with a walk.

Reds Player Leaders

• Sal Stewart has 12 doubles, 12 home runs and 33 walks while batting .258. He's slugging .467 with an on-base percentage of .351.
• Including all qualifying hitters in the majors, he ranks 66th in batting average, 55th in on-base percentage and 45th in slugging percentage.
• Spencer Steer's .353 OBP paces his team. He has a batting average of .278 while slugging .464.
• Including all qualifying players, he is 43rd in batting average, 49th in on-base percentage and 46th in slugging percentage.
• JJ Bleday is hitting .289 with eight doubles, a triple, 10 home runs and 19 walks.
• Nathaniel Lowe has nine doubles, nine home runs and 16 walks while batting .250.

Cardinals vs Reds Head to Head

• 5/23/2026: 7-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2026: 8-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/17/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/16/2025: 3-0 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2025: 11-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)

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