Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 5

Odds updated as of 8:12 p.m.

On Friday in MLB, the St. Louis Cardinals are playing the Cincinnati Reds.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Reds Game Info

• St. Louis Cardinals (32-28) vs. Cincinnati Reds (31-30)
• Date: Friday, June 5, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Reds.TV

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-142) | CIN: (+120)
• Spread: STL: -1.5 (+142) | CIN: +1.5 (-176)
• Total: 9.5 -- Over: (+102) | Under: (-124)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Kyle Leahy (Cardinals) - 5-3, 4.25 ERA vs Brady Singer (Reds) - 2-5, 6.18 ERA

The Cardinals will look to Kyle Leahy (5-3) against the Reds and Brady Singer (2-5). Leahy and his team are 5-5-0 ATS this season when he starts. Leahy's team lost his only start as a favorite this season. When Singer starts, the Reds have gone 6-4-0 against the spread. The Reds are 4-4 in Singer's eight starts this season that they were the moneyline underdog.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.5%)

Cardinals vs Reds Moneyline

• Cincinnati is a +120 underdog on the moneyline, while St. Louis is a -142 favorite at home.

Cardinals vs Reds Spread

• The Cardinals are favored by 1.5 runs at home against the Reds. The Cardinals are +142 to cover the spread, while the Reds are -176.

Cardinals vs Reds Over/Under

• The over/under for Cardinals-Reds on June 5 is 9.5. The over is +102, and the under is -124.

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Cardinals vs Reds Betting Trends

• The Cardinals have been chosen as favorites in 11 games this year and have walked away with the win six times (54.5%) in those games.
• St. Louis has not played a game this season with better moneyline odds than -142.
• The Cardinals and their opponents have hit the over in 25 of their 59 games with a total set by oddsmakers this season.
• The Cardinals are 35-24-0 against the spread in their 59 games that had a posted line this season.
• The Reds have won 20 of the 37 games they were listed as the moneyline underdog this season (54.1%).
• Cincinnati has a 4-7 record (winning just 36.4% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Reds have had an over/under set by oddsmakers 59 times, and have combined with opponents to go over the total in 36 of those games (36-22-1).
• The Reds are 33-26-0 against the spread this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis in slugging percentage (.537) and total hits (66) this season. He's batting .291 with an on-base percentage of .355.
• Among all qualifying hitters, he is 23rd in batting average, his on-base percentage ranks 46th, and he is 12th in slugging.
• Walker hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .238 with two RBIs.
• Alec Burleson has an OPS of .795, fueled by an OBP of .352 and a team-best slugging percentage of .443 this season. He's batting .287.
• Among qualified hitters, his batting average ranks him 27th, his on-base percentage 51st, and his slugging percentage 62nd.
• Burleson heads into this game looking to extend his five-game hit streak. In his last five games he is batting .400 with two doubles, a walk and seven RBIs.
• Ivan Herrera leads St. Louis in OBP (.382) this season, fueled by 58 hits.
• Herrera heads into this game with two games in a row with at least one hit. During his last five outings he is batting .200 with a walk.
• JJ Wetherholt is batting .249 with a .357 OBP and 25 RBI for St. Louis this season.

Reds Player Leaders

• Sal Stewart is batting .258 with 12 doubles, 12 home runs and 33 walks. He's slugging .467 with an on-base percentage of .351.
• Including all the qualifying hitters in the majors, he is 66th in batting average, 54th in on-base percentage and 45th in slugging percentage.
• Spencer Steer has a .353 OBP to lead his team. He has a batting average of .278 while slugging .464.
• Including all qualified players, he ranks 43rd in batting average, 49th in on-base percentage and 46th in slugging percentage.
• JJ Bleday has eight doubles, a triple, 10 home runs and 19 walks while batting .289.
• Nathaniel Lowe is batting .250 with nine doubles, nine home runs and 16 walks.

Cardinals vs Reds Head to Head

• 5/23/2026: 7-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2026: 8-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/17/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/16/2025: 3-0 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2025: 11-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)

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