Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 28

Odds updated as of 9:11 p.m.

MLB action on Thursday includes the St. Louis Cardinals taking on the Pittsburgh Pirates.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Pirates Game Info

• St. Louis Cardinals (65-68) vs. Pittsburgh Pirates (58-75)
• Date: Thursday, August 28, 2025
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SportsNet PT

Cardinals vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-122) | PIT: (+104)
• Spread: STL: -1.5 (+164) | PIT: +1.5 (-200)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Cardinals vs Pirates Probable Starting Pitchers

Probable Pitchers: Miles Mikolas (Cardinals) - 6-10, 5.17 ERA vs Braxton Ashcraft (Pirates) - 4-2, 2.70 ERA

This contest's pitching matchup is set, as the Cardinals will send Miles Mikolas (6-10) to the mound, while Braxton Ashcraft (4-2) will take the ball for the Pirates. Mikolas and his team have a record of 10-15-0 against the spread when he starts. Mikolas' team is 4-3 this season when he starts and they are the moneyline favorite. The Pirates covered all of the four games Ashcraft has started that had a spread set by bookmakers. The Pirates were the underdog on the moneyline for two Ashcraft starts this season -- they won both.

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.6%)

Cardinals vs Pirates Moneyline

• The moneyline numbers for Cardinals vs. Pirates reveal St. Louis as the favorite (-122) and Pittsburgh as the underdog (+104) on the road.

Cardinals vs Pirates Spread

• The Pirates are at +1.5 on the runline against the Cardinals. The Pirates are -200 to cover the spread, and the Cardinals are +164.

Cardinals vs Pirates Over/Under

• The Cardinals-Pirates game on Aug. 28 has been given an over/under of 8.5 runs. The over is set at -114 and the under at -106.

Bet on St. Louis Cardinals vs. Pittsburgh Pirates on FanDuel today!

Cardinals vs Pirates Betting Trends

• The Cardinals have won in 29, or 50.9%, of the 57 contests they have been named as odds-on favorites in this year.
• St. Louis has a record of 21-19 when favored by -122 or more this year.
• The Cardinals' games have gone over the total in 67 of their 127 opportunities.
• In 127 games with a line this season, the Cardinals have a mark of 64-63-0 against the spread.
• The Pirates have a 35-50 record in games they were listed as the moneyline underdog (winning 41.2% of those games).
• Pittsburgh has gone 31-45 in games it has played as a moneyline underdog with odds of +104 or longer (40.8%).
• The Pirates have played in 125 games with an over/under set, and have combined with opponents to go over the total 50 times (50-69-6).
• The Pirates have covered 54.4% of their games this season, going 68-57-0 against the spread.

Cardinals Player Leaders

• Alec Burleson has 123 hits to go with a slugging percentage of .459, both of which are tops among St. Louis hitters this season. He has a .291 batting average and an on-base percentage of .341.
• Among qualified batters in the majors, he is 14th in batting average, 56th in on-base percentage, and 53rd in slugging.
• Burleson hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .364 with a double, a home run and three RBIs.
• Willson Contreras is batting .259 with 30 doubles, 19 home runs and 40 walks, while slugging .455 with an on-base percentage of .343.
• He is 77th in batting average, 53rd in on-base percentage and 58th in slugging among qualified hitters.
• Masyn Winn has 116 hits this season and has a slash line of .256/.310/.372.
• Lars Nootbaar has 13 home runs, 44 RBI and a batting average of .234 this season.

Pirates Player Leaders

• Bryan Reynolds has 122 hits with a .414 slugging percentage, both team-high numbers for the Pirates. He's batting .247 and with an on-base percentage of .306.
• Including all the qualified hitters in the big leagues, he is 102nd in batting average, 121st in on-base percentage and 92nd in slugging percentage.
• Oneil Cruz is batting .205 with 17 doubles, two triples, 18 home runs and 55 walks. He's slugging .394 with an on-base percentage of .303.
• He ranks 154th in batting average, 126th in on-base percentage and 116th in slugging percentage in the big leagues.
• Andrew McCutchen has put up an on-base percentage of .333, a team-high for the Pirates.
• Isiah Kiner-Falefa has 19 doubles, two triples, a home run and 17 walks while hitting .267.

Cardinals vs Pirates Head to Head

• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2025: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/2/2025: 5-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/1/2025: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/7/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/6/2025: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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