Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 17

Odds updated as of 2:11 p.m.

On Wednesday in MLB, the St. Louis Cardinals are up against the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Padres Game Info

• St. Louis Cardinals (40-31) vs. San Diego Padres (37-35)
• Date: Wednesday, June 17, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Padres.TV

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-130) | SD: (+110)
• Spread: STL: -1.5 (+150) | SD: +1.5 (-182)
• Total: 10.5 -- Over: (-108) | Under: (-112)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Kyle Leahy (Cardinals) - 5-3, 4.64 ERA vs Bradgley Rodriguez (Padres) - 1-2, 2.16 ERA

The probable starters are Kyle Leahy (5-3) for the Cardinals and Bradgley Rodriguez (1-2) for the Padres. Leahy's team is 7-5-0 against the spread in his starts this season. Leahy's team is 1-1 this season when he starts and they're favored on the moneyline. Rodriguez has started two games with set spreads, and the Padres went 1-1-0. The Padres were the underdog on the moneyline for one Rodriguez start this season -- they lost.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (62%)

Cardinals vs Padres Moneyline

• Looking at the moneyline for Padres-Cardinals, San Diego is the underdog at +110, and St. Louis is -130 playing at home.

Cardinals vs Padres Spread

• The Cardinals are hosting the Padres and are favored by 1.5 runs (+150 to cover) on the runline. San Diego is -182 to cover.

Cardinals vs Padres Over/Under

• A combined run total of 10.5 has been set for Cardinals-Padres on June 17, with the over at -108 and the under at -112.

Bet on St. Louis Cardinals vs. San Diego Padres on FanDuel today!

Cardinals vs Padres Betting Trends

• The Cardinals have been favorites in 17 games this season and have come away with the win 12 times (70.6%) in those contests.
• St. Louis has not lost in three games this year when favored by -130 or better on the moneyline.
• The Cardinals and their opponents have gone over in 30 of their 70 games with a total set by sportsbooks this season.
• The Cardinals have posted a record of 44-26-0 against the spread this season.
• The Padres are 17-19 in games they were the underdog on the moneyline (winning 47.2% of those games).
• San Diego has gone 10-12 when playing as a moneyline underdog with odds of +110 or longer (45.5%).
• The Padres have played in 72 games with an over/under set, and have combined with their opponents to go over the total 31 times (31-40-1).
• The Padres have a 38-34-0 record against the spread this season (covering 52.8% of the time).

Cardinals Player Leaders

• Alec Burleson is hitting .285 with 18 doubles, 13 home runs and 26 walks. He has an on-base percentage of .349 while slugging .491.
• Among the qualified batters in the majors, his batting average ranks 24th, his on-base percentage ranks 51st, and he is 30th in slugging.
• Burleson will look for his 17th straight game with a hit in this matchup. During his last 10 outings he is batting .256 with three doubles, five home runs, three walks and nine RBIs.
• Jordan Walker leads St. Louis with 81 hits and a team-best slugging percentage of .545. He's batting .292 with an on-base percentage of .346.
• His batting average ranks 15th among qualified players, his on-base percentage 57th, and his slugging percentage 12th.
• Ivan Herrera leads St. Louis with an OBP of .396 this season while batting .261 with 42 walks and 48 runs scored.
• JJ Wetherholt has 10 home runs, 31 RBI and a batting average of .259 this season.

Padres Player Leaders

• Fernando Tatis Jr. has racked up a team-best OBP (.344) and slugging percentage (.344). He's batting .278.
• Including all qualified hitters, he ranks 36th in batting average, while his on-base percentage ranks 61st and he is 134th in slugging.
• Gavin Sheets' 47 hits pace his team. He has a batting average of .225 while slugging .445 with an on-base percentage of .314.
• He is currently 126th in batting average, 107th in on-base percentage and 58th in slugging percentage among all qualifying batters.
• Manny Machado is batting .175 with 10 doubles, 12 home runs and 29 walks.
• Xander Bogaerts has four doubles, eight home runs and 26 walks while batting .222.

Cardinals vs Padres Head to Head

• 6/16/2026: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/15/2026: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/10/2026: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/9/2026: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2026: 6-0 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/7/2026: 2-1 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/3/2025: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/2/2025: 8-5 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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