Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 17

Odds updated as of 6:12 a.m.

The Wednesday schedule in MLB includes a matchup between the St. Louis Cardinals and the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Padres Game Info

• St. Louis Cardinals (40-31) vs. San Diego Padres (37-35)
• Date: Wednesday, June 17, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Padres.TV

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-120) | SD: (+102)
• Spread: STL: +1.5 (-192) | SD: -1.5 (+158)
• Total: 10.5 -- Over: (+102) | Under: (-124)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Kyle Leahy (Cardinals) - 5-3, 4.64 ERA vs TBA (Padres)

The Cardinals will give the ball to Kyle Leahy (5-3), while the Padres' starting pitcher has not yet been announced. Leahy's team is 7-5-0 against the spread this season in his starts. Leahy's team is 1-1 this season when he starts and they're favored on the moneyline.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (60.6%)

Cardinals vs Padres Moneyline

• St. Louis is the favorite, -120 on the moneyline, while San Diego is a +102 underdog on the road.

Cardinals vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Cardinals. The Padres are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs Padres Over/Under

• A combined run total of 10.5 has been set for Cardinals-Padres on June 17, with the over at +102 and the under at -124.

Bet on St. Louis Cardinals vs. San Diego Padres on FanDuel today!

Cardinals vs Padres Betting Trends

• The Cardinals have been favorites in 17 games this season and have come away with the win 12 times (70.6%) in those contests.
• This season St. Louis has come away with a win seven times in eight chances when named as a favorite of at least -120 on the moneyline.
• The Cardinals' games have gone over the total in 30 of their 70 opportunities.
• The Cardinals are 44-26-0 against the spread in their 70 games with a line set by sportsbooks this season.
• The Padres have won 17 of the 36 games they were the moneyline underdog this season (47.2%).
• When playing as a moneyline underdog with odds of +102 or longer, San Diego has a 14-16 record (winning 46.7% of its games).
• The Padres have played in 72 games with a set over/under, and have combined with their opponents to go over the total 31 times (31-40-1).
• The Padres have covered 52.8% of their games this season, going 38-34-0 ATS.

Cardinals Player Leaders

• Alec Burleson is batting .285 with 18 doubles, 13 home runs and 26 walks. He has an on-base percentage of .349 while slugging .491.
• Among all qualified hitters in MLB, he ranks 24th in batting average, 51st in on-base percentage, and 30th in slugging.
• Burleson will look for his 17th straight game with a hit in this contest. In his last 10 outings he is hitting .256 with three doubles, five home runs, three walks and nine RBIs.
• Jordan Walker has 81 hits to go with a slugging percentage of .545, both of which are tops among St. Louis hitters this season. He's batting .292 with an on-base percentage of .346.
• Among qualifying batters, he is 15th in batting average, 57th in on-base percentage and 12th in slugging percentage.
• Ivan Herrera has 68 hits this season and a team-best OBP of .396.
• JJ Wetherholt is batting .259 with a .362 OBP and 31 RBI for St. Louis this season.

Padres Player Leaders

• Fernando Tatis Jr. has racked up a team-best OBP (.344) and slugging percentage (.344). He's batting .278.
• Including all the qualifying hitters in the majors, his batting average is 36th, his on-base percentage is 61st, and he is 134th in slugging.
• Gavin Sheets' 47 hits pace his team. He has a batting average of .225 while slugging .445 with an on-base percentage of .314.
• He ranks 126th in batting average, 107th in on-base percentage and 58th in slugging percentage in MLB.
• Manny Machado is hitting .175 with 10 doubles, 12 home runs and 29 walks.
• Xander Bogaerts is batting .222 with four doubles, eight home runs and 26 walks.

Cardinals vs Padres Head to Head

• 6/16/2026: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/15/2026: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/10/2026: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/9/2026: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2026: 6-0 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/7/2026: 2-1 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/3/2025: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/2/2025: 8-5 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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