Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 16

Odds updated as of 7:12 p.m.

Tuesday's slate in the MLB includes a matchup between the St. Louis Cardinals and the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Cardinals vs Padres Game Info

• St. Louis Cardinals (39-31) vs. San Diego Padres (37-34)
• Date: Tuesday, June 16, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: TBS, Cardinals.TV, and Padres.TV

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-118) | SD: (+100)
• Spread: STL: +1.5 (-205) | SD: -1.5 (+168)
• Total: 8.5 -- Over: (+102) | Under: (-124)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 7-4, 3.88 ERA vs Michael King (Padres) - 4-5, 3.46 ERA

The Cardinals will call on Andre Pallante (7-4) against the Padres and Michael King (4-5). Pallante's team is 9-4-0 against the spread in his starts this season. When Pallante starts a game and his team is the favorite on the moneyline, they have a record of 1-3. The Padres have gone 4-10-0 ATS in King's 14 starts with a set spread. The Padres are 3-1 in King's four starts this season that they were the moneyline underdog.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (58.1%)

Cardinals vs Padres Moneyline

• St. Louis is a -118 favorite on the moneyline, while San Diego is a +100 underdog on the road.

Cardinals vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Cardinals. The Padres are +168 to cover, while the Cardinals are -205 to cover as a 1.5-run underdog on the runline.

Cardinals vs Padres Over/Under

• A combined run total of 8.5 has been set for Cardinals-Padres on June 16, with the over at +102 and the under at -124.

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Cardinals vs Padres Betting Trends

• The Cardinals have been favorites in 16 games this season and have come away with the win 11 times (68.8%) in those contests.
• This season St. Louis has come away with a win seven times in eight chances when named as a favorite of at least -118 on the moneyline.
• The Cardinals' games have gone over the total in 30 of their 69 opportunities.
• The Cardinals have posted a record of 43-26-0 against the spread this season.
• The Padres have won 48.6% of the games this season they were the moneyline underdog (17-18).
• San Diego has a 14-16 record (winning 46.7% of its games) when it has played as a moneyline underdog of +100 or longer.
• The Padres have played in 71 games with an over/under set, and have combined with opponents to go over the total 31 times (31-39-1).
• The Padres have collected a 38-33-0 record ATS this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 81 hits and a team-best slugging percentage of .553. He's batting .297 with an on-base percentage of .350.
• Among all qualifying hitters in MLB, his batting average ranks 13th, his on-base percentage ranks 53rd, and he is 11th in slugging.
• Alec Burleson is batting .287 with 18 doubles, 13 home runs and 26 walks. He's slugging .496 with an on-base percentage of .351.
• He is 22nd in batting average, 50th in on-base percentage and 26th in slugging among qualifying hitters.
• Burleson heads into this matchup looking to extend his 15-game hit streak. During his last 10 outings he is hitting .286 with three doubles, six home runs, four walks and 10 RBIs.
• Ivan Herrera leads St. Louis in OBP (.396) this season, fueled by 68 hits.
• JJ Wetherholt has 10 home runs, 31 RBI and a batting average of .251 this season.

Padres Player Leaders

• Gavin Sheets is leading the Padres with 47 hits. He's batting .228 and slugging .451 with an on-base percentage of .318.
• Including all qualifying players in MLB, he ranks 123rd in batting average, 102nd in on-base percentage and 51st in slugging percentage.
• Fernando Tatis Jr. has a .345 OBP while slugging .346. Both pace his team. He has a batting average of .279.
• His batting average ranks 36th among all qualified players, his on-base percentage is 61st, and he is 133rd in slugging.
• Manny Machado is batting .177 with 10 doubles, 12 home runs and 28 walks.
• Xander Bogaerts is hitting .226 with four doubles, eight home runs and 26 walks.

Cardinals vs Padres Head to Head

• 6/15/2026: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/10/2026: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/9/2026: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2026: 6-0 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/7/2026: 2-1 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/3/2025: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/2/2025: 8-5 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)

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