Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 15

Odds updated as of 7:12 p.m.

The St. Louis Cardinals versus the San Diego Padres is on the MLB schedule for Monday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Padres Game Info

• St. Louis Cardinals (38-31) vs. San Diego Padres (37-33)
• Date: Monday, June 15, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Padres.TV

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-166) | SD: (+140)
• Spread: STL: -1.5 (+134) | SD: +1.5 (-162)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Dustin May (Cardinals) - 4-6, 4.21 ERA vs Wandy Peralta (Padres) - 1-0, 2.18 ERA

The Cardinals will give the ball to Dustin May (4-6, 4.21 ERA), who is eyeing win No. 5 on the season, and the Padres will turn to Wandy Peralta (1-0, 2.18 ERA). When May starts, his team is 7-6-0 against the spread this season. May's team is 2-0 this season when he starts and they're favored on the moneyline. Last season Peralta pitched in one game with a spread, which his team covered. Peralta's team was the moneyline underdog only one time in a game he pitched a season ago, and lost.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.8%)

Cardinals vs Padres Moneyline

• San Diego is a +140 underdog on the moneyline, while St. Louis is a -166 favorite at home.

Cardinals vs Padres Spread

• The Cardinals are hosting the Padres and are favored by 1.5 runs on the spread. The Cardinals are +134 to cover the runline, with the Padres being -162.

Cardinals vs Padres Over/Under

• Cardinals versus Padres on June 15 has an over/under of 8.5 runs, with the odds on the over -114 and the under set at -106.

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Cardinals vs Padres Betting Trends

• The Cardinals have been victorious in 10, or 66.7%, of the 15 contests they have been chosen as favorites in this season.
• Oddsmakers have given St. Louis the best odds of winning it has seen this season, with a -166 moneyline listed for this contest.
• The Cardinals and their opponents have gone over the total this season in 30 of their 68 opportunities.
• The Cardinals have an against the spread record of 42-26-0 in 68 games with a line this season.
• The Padres are 17-17 in games they were listed as the moneyline underdog (winning 50% of those games).
• When playing as a moneyline underdog with odds of +140 or longer, San Diego has a record of 1-3 (25%).
• The Padres have played in 70 games with an over/under set, and have combined with opponents to go over the total 31 times (31-38-1).
• The Padres have a 38-32-0 record ATS this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 79 hits and a team-best slugging percentage of .554. He's batting .294 with an on-base percentage of .348.
• Among all qualified hitters in the majors, his batting average ranks 17th, his on-base percentage ranks 56th, and he is ninth in slugging.
• Alec Burleson is batting .287 with 17 doubles, 13 home runs and 26 walks, while slugging .496 with an on-base percentage of .352.
• Among qualifying hitters, his batting average places him 22nd, his on-base percentage 46th, and his slugging percentage 28th.
• Burleson has picked up at least one hit in 14 games in a row. In his last 10 games he is batting .310 with three doubles, six home runs, four walks and 12 RBIs.
• Ivan Herrera leads St. Louis in OBP (.398) this season, fueled by 68 hits.
• JJ Wetherholt has 10 home runs, 31 RBI and a batting average of .255 this season.
• Wetherholt heads into this game on a two-game hitting streak. During his last five outings he is hitting .348 with a home run, a walk and six RBIs.

Padres Player Leaders

• Gavin Sheets has 47 hits, a team-best for the Padres. He's batting .232 and slugging .458 with an on-base percentage of .322.
• Including all qualifying hitters in MLB, he is 113th in batting average, 97th in on-base percentage and 48th in slugging percentage.
• Sheets takes a four-game hitting streak into this matchup. During his last five outings he is hitting .250 with two doubles, a home run, two walks and four RBIs.
• Fernando Tatis Jr. leads his team with a .347 OBP, and has a club-best .350 slugging percentage. He has a batting average of .282.
• Including all qualifying players, he ranks 26th in batting average, 58th in on-base percentage and 131st in slugging percentage.
• Xander Bogaerts is hitting .228 with four doubles, eight home runs and 26 walks.
• Manny Machado is batting .175 with 10 doubles, 12 home runs and 28 walks.

Cardinals vs Padres Head to Head

• 5/10/2026: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/9/2026: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2026: 6-0 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/7/2026: 2-1 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/3/2025: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/2/2025: 8-5 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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